Explore popular diseases in clinical trials

Check which popular diseases are currently being frequently studied.

See also our rare diseases glossary and drug database.

Starting by letter

To open the diseases glossary, select a letter from the list below.

Most popular diseases

The list below features the most popular diseases currently involved in ongoing clinical trials.

Disease trials
Non-small cell lung cancer 240
Breast cancer 99
Obesity 92
Prostate cancer 77
Colorectal cancer 69
Ovarian cancer 68
Crohn’s disease 67
Non-small cell lung cancer metastatic 64
Rheumatoid arthritis 55
Squamous cell carcinoma of head and neck 54
Triple negative breast cancer 54
Chronic kidney disease 50
Asthma 50
Hepatocellular carcinoma 47
Neoplasm 47
Acute myeloid leukaemia 47
Colorectal cancer metastatic 46
Overweight 45
Multiple sclerosis 43
Colitis ulcerative 40
Parkinson’s disease 40
HER2 positive breast cancer 39
Gastric cancer 38
Myelodysplastic syndrome 38
Dementia Alzheimer’s type 37
Glioblastoma 36
Bladder cancer 34
Atrial fibrillation 34
Prostate cancer metastatic 34
Renal transplant 33
Ischaemic stroke 33
Diffuse large B-cell lymphoma 32
Chronic obstructive pulmonary disease 32
Head and neck cancer 32
Non-small cell lung cancer stage IV 31
Breast cancer metastatic 30
Coronary artery disease 29
Myasthenia gravis 29
Malignant melanoma 29
Endometrial cancer 28
Cholangiocarcinoma 28
Rectal cancer 27
Pulmonary arterial hypertension 27
Dermatitis atopic 27
Idiopathic pulmonary fibrosis 27
Soft tissue sarcoma 26
Non-small cell lung cancer stage III 26
Plasma cell myeloma 25
Pancreatic carcinoma 25
Small cell lung cancer extensive stage 25
Sepsis 25
Renal cell carcinoma 25
Schizophrenia 24
COVID-19 24
Duchenne muscular dystrophy 24
Non-small cell lung cancer stage IIIB 24
Follicular lymphoma 24
Hormone receptor positive breast cancer 24
Fallopian tube cancer 23
Amyotrophic lateral sclerosis 23
Mantle cell lymphoma 23
Influenza 22
Neoplasm malignant 22
Chronic lymphocytic leukaemia 21
Acute myocardial infarction 21
Major depression 21
Small cell lung cancer 21
Sickle cell disease 21
Interstitial lung disease 21
Cystic fibrosis 21
Breast cancer female 20
Osteoarthritis 20
Glioma 20
Neuroblastoma 20
Chronic rhinosinusitis with nasal polyps 20
Oesophageal adenocarcinoma 20
Myelofibrosis 19
B-cell lymphoma 19
Critical illness 18
Procedural pain 18
Acute kidney injury 18
Psoriasis 18
Axial spondyloarthritis 18
Acute coronary syndrome 17
Vitiligo 17
Hereditary angioedema 17
Relapsing-remitting multiple sclerosis 17
Ewing’s sarcoma 17
IgA nephropathy 17
Gastrooesophageal cancer 16
Juvenile idiopathic arthritis 16
Cardiac failure 16
Uveal melanoma 16
Chronic hepatitis B 16
Allogenic stem cell transplantation 15
Giant cell arteritis 15
Chronic spontaneous urticaria 15
Cardiac arrest 15
Septic shock 14
Malignant melanoma stage III 14

All diseases

  • 3

    Borderline personality disorder

    Borderline personality disorder is a mental health condition that affects how you feel about yourself and others, making relationships and everyday life challenging. But with effective treatment, many people with this condition learn to live stabler, more fulfilling lives.

  • 2

    BRAF gene mutation

    A mutation in the BRAF gene can lead to uncontrolled cell growth and the development of cancer in various organs throughout the body. Understanding whether your cancer has this genetic change is important because it can guide doctors toward the most effective treatment options for you.

  • 1

    Brain abscess

    A brain abscess is a dangerous collection of pus within the brain that requires urgent medical attention. This life-threatening infection can develop when bacteria or fungi invade brain tissue, causing swelling that puts pressure on the brain and disrupts its normal function.

  • 0

    Brain cancer metastatic

    Brain metastases occur when cancer from another part of your body spreads to your brain, forming one or more new tumors that can affect how you think, move, and feel.

  • 4

    Brain injury

    Every 9 seconds, someone in the United States sustains a brain injury—an event that can change everything about a person in a matter of seconds. While brain injuries affect millions worldwide each year, no two injuries are exactly alike, making each person’s journey unique.

  • 2

    Brain neoplasm

    Brain neoplasms are abnormal growths of cells in or around the brain that can range from slow-growing masses to aggressive cancers, affecting people of all ages and requiring specialized care tailored to each individual tumor type.

  • 1

    Brain neoplasm malignant

    Malignant brain tumors are cancerous growths that develop in the brain and require swift medical intervention. These aggressive tumors can grow quickly and invade healthy brain tissue, affecting thousands of lives each year.

  • 5

    Brain stem glioma

    Brain stem glioma is a type of tumor that develops in the brainstem, the critical area connecting your brain to your spinal cord. While these tumors most commonly affect children, they can also occur in adults, and their behavior and outlook vary greatly depending on their location and how fast they grow.

  • 1

    Breast angiosarcoma

    Breast angiosarcoma is a very rare and aggressive cancer that starts in the cells lining blood or lymph vessels in the breast. While it accounts for less than 1% of all breast cancers, people who have received radiation therapy for breast cancer face a higher risk of developing this disease years after treatment.

  • 1

    Breast angiosarcoma metastatic

    Breast angiosarcoma that has spread to other parts of the body is a rare and aggressive form of cancer that presents unique challenges for patients and doctors. Understanding this disease and available treatment options can help patients navigate their journey with greater confidence.

  • 95

    Breast cancer

    Breast cancer happens when cells in the breast tissue grow out of control and form tumors. It is one of the most common cancers affecting women worldwide, though men can develop it too. While a breast cancer diagnosis can be overwhelming, advances in early detection and treatment have led to improved survival rates and better outcomes for many people.

  • 19

    Breast cancer female

    Breast cancer is a condition where cells in breast tissue grow out of control and form tumors. While it is the most common cancer diagnosed in women and the second leading cause of cancer death among women worldwide, advances in early detection and treatment have significantly improved survival rates.

  • 1

    Breast cancer in situ

    Ductal carcinoma in situ is a very early form of breast cancer where abnormal cells are found inside the milk ducts but have not spread into surrounding breast tissue. While not immediately life-threatening, understanding this condition and its treatment options is essential for anyone who receives this diagnosis.

  • 5

    Breast cancer male

    Though rare, breast cancer does occur in men because they have breast tissue that can become cancerous, just like in women. Understanding the signs, knowing your risk factors, and seeking prompt medical attention for any unusual changes can make a crucial difference in outcomes.

  • 29

    Breast cancer metastatic

    Metastatic breast cancer is breast cancer that has spread beyond the breast and nearby lymph nodes to other parts of the body. While there is currently no cure, many people are living longer than ever before thanks to advances in treatment, and it is possible to live well with this disease for many years.

  • 4

    Breast cancer recurrent

    Breast cancer recurrence is when cancer returns after treatment, sometimes months or even years later. While most people treated for breast cancer will not experience a recurrence, understanding the types, symptoms, and treatment options can help you stay informed and prepared.

  • 2

    Breast cancer stage I

    Stage 1 breast cancer is the earliest stage of invasive breast cancer, where the tumor is small and contained within the breast or has spread only minimally to nearby lymph nodes. With treatment, people diagnosed at this stage typically have excellent chances of recovery.

  • 4

    Breast cancer stage II

    Stage 2 breast cancer is an early stage of the disease where cancer cells are either in the breast tissue or nearby lymph nodes, or both. With modern treatments and early detection, many people with stage 2 breast cancer can be successfully treated and go on to live full, healthy lives.

  • 4

    Breast cancer stage III

    Stage 3 breast cancer, also called locally advanced breast cancer, means the cancer has spread beyond the breast tissue to nearby lymph nodes or surrounding structures, but has not reached distant parts of the body.

  • 2

    Breast cancer stage IV

    Stage 4 breast cancer means the cancer has spread beyond the breast to other parts of the body. While there is no cure, many people are living longer than ever before thanks to newer treatments that can control the disease and help maintain quality of life.

  • 1

    Breast conserving surgery

    Breast conserving surgery offers women with early breast cancer a way to remove the tumor while keeping most of their breast tissue intact, achieving survival rates equal to mastectomy when combined with radiation therapy.

  • 1

    Breast neoplasm

    Breast neoplasm, commonly known as breast cancer, is a disease where cells in the breast tissue grow out of control and form tumors. While it most often affects women over 50, it can also occur in younger women and men. With advances in early detection and treatment, many people diagnosed with breast cancer can be successfully treated and go on to live long, healthy lives.

  • 0

    Breast proliferative changes

    Breast proliferative changes represent a group of benign breast conditions where cells in the breast ducts or lobules grow faster than normal. While most of these changes are not cancerous, some types can increase a woman’s risk of developing breast cancer in the future.

  • 10

    Bronchiectasis

    Bronchiectasis is a chronic lung condition where the airways become permanently widened and damaged, making it difficult to clear mucus and leading to frequent infections that can worsen over time.

  • 3

    Bronchiolitis

    Bronchiolitis is a common lung infection that affects babies and young children, causing inflammation and mucus buildup in the tiny airways of the lungs, which can make breathing difficult.

  • 1

    Bronchiolitis obliterans syndrome

    Bronchiolitis obliterans syndrome is a serious lung condition that causes the smallest airways in the lungs to become inflamed, damaged, and scarred, making it difficult to breathe. It most commonly occurs after organ transplants, but can also develop from breathing in harmful chemicals or after severe infections.

  • 1

    Bronchitis

    Bronchitis occurs when the airways in your lungs become inflamed and fill with mucus, causing you to cough persistently. While most cases clear up on their own within a few weeks, understanding the difference between acute and chronic forms can help you manage symptoms and know when to seek medical care.

  • 1

    Bronchopulmonary aspergillosis

    Bronchopulmonary aspergillosis is a lung condition that develops when the immune system overreacts to a common fungus found in soil and decaying plants, causing inflammation that can worsen breathing problems in people with asthma or cystic fibrosis.

  • 7

    Bronchopulmonary dysplasia

    Bronchopulmonary dysplasia is a serious lung condition that primarily affects babies born too early, when their lungs are not yet fully developed. While these tiny infants often need life-saving oxygen therapy and breathing support, this same treatment can damage their delicate lungs over time, leading to long-term breathing difficulties.

  • 1

    Bronchostenosis

    Bronchostenosis is a chronic narrowing of the bronchi, the tubes that carry air into your lungs. This narrowing can make breathing difficult and lead to repeated lung infections, requiring ongoing medical care and lifestyle adjustments to maintain quality of life.

  • 1

    Bulbospinal muscular atrophy congenital

    Bulbospinal muscular atrophy is a rare genetic condition that primarily affects adult men, causing slow but steady muscle weakness that develops over decades.

  • 3

    Burkitt’s lymphoma

    Burkitt’s lymphoma is a rare but fast-growing cancer that develops in the body’s infection-fighting system. Though it can be life-threatening because of how quickly it spreads, most people respond well to treatment and can go into long-term remission when diagnosed and treated right away.

  • 1

    Burning mouth syndrome

    Burning mouth syndrome is a painful condition where your mouth feels like it’s burning, even though there are no visible changes. It most commonly affects women after menopause and can last for months or years, making everyday activities like eating and talking challenging.

  • 1

    Bush-Francis catatonia rating scale

    The Bush-Francis Catatonia Rating Scale is a specialized tool that helps doctors identify and measure the severity of catatonia, a complex condition involving unusual movements and behaviors that affects about 10% of psychiatric patients but often goes undiagnosed.

  • 4

    C3 glomerulopathy

    C3 glomerulopathy is a rare kidney disease caused by problems with the body’s immune system, specifically affecting tiny filtering structures in the kidneys that help clean the blood and make urine.

  • 1

    Cachexia

    Cachexia is a devastating syndrome that causes severe weight loss and muscle wasting in people with serious illnesses like cancer, heart disease, and chronic lung conditions. This condition affects millions of people worldwide and can significantly impact quality of life, treatment outcomes, and survival.

  • 1

    CADASIL

    CADASIL is a rare inherited disorder that affects the blood vessels in the brain, causing symptoms that can include migraine headaches, strokes, and changes in memory and thinking. Understanding this condition can help patients and families navigate the challenges it presents.

  • 2

    Caesarean section

    A caesarean section is a surgical procedure that delivers a baby through incisions made in the mother’s abdomen and uterus when a vaginal birth isn’t safe or possible. It is one of the most common surgical procedures performed today, accounting for about 30% of all births in the United States.

  • 1

    Cancer fatigue

    Cancer fatigue is one of the most common side effects experienced by people with cancer, affecting more than 80% of those receiving treatment. Unlike ordinary tiredness, this profound exhaustion doesn’t go away with rest or sleep and can impact every aspect of daily life.

  • 4

    Cancer pain

    Pain is one of the most common symptoms people with cancer face, affecting nearly half of all patients and even more of those with advanced disease. Yet with proper pain management, most people can find relief and maintain a better quality of life throughout their cancer journey.

  • 0

    Candida infection

    Candida infection occurs when a type of yeast that naturally lives in your body grows out of control, causing uncomfortable symptoms like itching, burning, and unusual discharge. While most infections are easily treatable with antifungal medications, understanding what triggers them can help you stay healthy.

  • 1

    Carcinoid syndrome

    Carcinoid syndrome is a rare condition that occurs when certain tumors release large amounts of hormones and other chemicals into your bloodstream, causing a range of uncomfortable and sometimes serious symptoms that can significantly affect your daily life.

  • 0

    Carcinoid tumour of the gastrointestinal tract

    Carcinoid tumours of the gastrointestinal tract are slow-growing cancers that often remain silent for years, sometimes discovered only by chance during surgery for other conditions. These rare tumours arise from hormone-producing cells scattered throughout the digestive system and can affect how your body processes food and regulates important chemical signals.

  • 0

    Carcinoid tumour pulmonary

    Lung carcinoid tumours are a rare type of cancer that starts in special cells in the lungs, growing slowly in most cases and rarely spreading to other parts of the body.

  • 13

    Cardiac amyloidosis

    Cardiac amyloidosis is a serious but increasingly treatable heart condition where misshapen proteins build up in your heart muscle, making it thick and stiff. Once considered untreatable, recent advances in diagnosis and therapy have transformed the outlook for people with this disease.

  • 15

    Cardiac arrest

    Cardiac arrest is a life-threatening emergency where the heart suddenly stops beating. Without immediate help, death can occur within minutes. Understanding what happens during cardiac arrest and knowing how to respond can mean the difference between life and death.

  • 1

    Cardiac disorder

    Cardiac disorder, often referred to as heart disease, encompasses a wide range of conditions that affect the heart and blood vessels. Understanding these conditions and knowing how to manage them can help you protect your heart and live a healthier life.

  • 16

    Cardiac failure

    When your heart can’t pump blood well enough to meet your body’s needs, a serious condition called heart failure develops. More than 6 million adults in the United States live with this condition, which requires lifelong management but can be controlled with proper treatment and lifestyle changes.

  • 2

    Cardiac failure acute

    Acute heart failure is a sudden, life-threatening medical emergency where your heart cannot pump enough blood to meet your body’s needs, causing oxygen-rich blood to fail reaching vital organs and tissues.

  • 7

    Cardiac failure chronic

    Chronic heart failure is a long-term condition where the heart cannot pump blood well enough to meet the body’s needs. While the heart is still working, it becomes too weak or stiff over time, causing blood and fluids to build up in the lungs, legs, and other parts of the body.

  • 1

    Cardiac failure congestive

    Congestive heart failure is a long-term condition where your heart can’t pump blood well enough to meet your body’s needs, causing blood and fluids to collect in your lungs and legs over time.

  • 1

    Cardiac function disturbance postoperative

    Heart rhythm problems and cardiovascular instability are among the most common complications after heart surgery, affecting recovery and hospital stay length. Understanding what can happen and how these issues are managed helps patients and families prepare for the journey ahead.

  • 2

    Cardiac sarcoidosis

    Cardiac sarcoidosis is a rare condition where tiny clumps of immune cells called granulomas form in your heart, causing inflammation that can disrupt normal heart function and lead to serious complications if left untreated.

  • 1

    Cardiac valve disease

    Cardiac valve disease affects the valves that control blood flow through your heart, and while many people live with mild valve problems without symptoms, more serious cases can weaken the heart and become life-threatening if left untreated.

  • 0

    Cardiac ventricular thrombosis

    Cardiac ventricular thrombosis is a serious condition where blood clots form inside the heart’s lower chambers, most commonly following a heart attack or in people with weakened heart muscle. While modern treatment methods have reduced how often this happens, it remains a significant risk that can lead to stroke and other life-threatening complications.

  • 0

    Cardio-respiratory arrest neonatal

    When a newborn’s heart and breathing stop, immediate action can save a life. Understanding how cardio-respiratory arrest happens in the youngest patients and knowing the proper response can make the difference between life and death.

  • 8

    Cardiogenic shock

    Cardiogenic shock is a life-threatening emergency where your heart suddenly cannot pump enough blood to meet your body’s needs. Without enough oxygen-rich blood reaching vital organs, this condition can quickly lead to organ failure and death if not treated immediately.

  • 7

    Cardiomyopathy

    Cardiomyopathy is a disease that affects the heart muscle, making it harder for your heart to pump blood to the rest of your body. This condition can affect people of all ages and may lead to serious heart problems, but treatment options are available to help manage symptoms and improve quality of life.

  • 7

    Cardiovascular disorder

    Cardiovascular disorder affects the heart and blood vessels, and is the leading cause of death worldwide. Almost half of all adults in the United States have at least one form of this condition, but many cases can be prevented through healthy lifestyle choices and proper medical care.

  • 1

    Cardiovascular somatic symptom disorder

    When physical symptoms like chest pain or palpitations cause overwhelming distress despite medical tests showing little or no serious heart problems, you may be experiencing a condition where the mind and body are deeply connected in ways that affect daily life.