Explore popular diseases in clinical trials

Check which popular diseases are currently being frequently studied.

See also our rare diseases glossary and drug database.

Starting by letter

To open the diseases glossary, select a letter from the list below.

Most popular diseases

The list below features the most popular diseases currently involved in ongoing clinical trials.

Disease Trials
Non-small cell lung cancer 238
Breast cancer 131
Neoplasm 124
Plasma cell myeloma 122
Acute myeloid leukaemia 102
Neoplasm malignant 91
Prostate cancer 89
Colitis ulcerative 87
Obesity 81
Colorectal cancer metastatic 80
Crohn’s disease 76
Dementia Alzheimer’s type 75
Ovarian cancer 71
Type 2 diabetes mellitus 71
Colorectal cancer 69
Dermatitis atopic 66
Malignant melanoma 65
Breast cancer metastatic 65
Hepatocellular carcinoma 63
Triple negative breast cancer 62
Chronic lymphocytic leukaemia 60
Asthma 60
Non-small cell lung cancer metastatic 59
Squamous cell carcinoma of head and neck 58
Rheumatoid arthritis 58
HIV infection 57
Hormone receptor positive HER2 negative breast cancer 55
Osteoarthritis 55
Renal transplant 50
Pancreatic carcinoma 49
Chronic kidney disease 49
Ischaemic stroke 45
Parkinson’s disease 44
Atrial fibrillation 44
Systemic lupus erythematosus 43
Multiple sclerosis 42
Gastric cancer 42
Oesophageal adenocarcinoma 40
Hormone-refractory prostate cancer 40
Bladder cancer 40
Chronic obstructive pulmonary disease 40
Psoriasis 40
Non-small cell lung cancer stage IV 40
Migraine 39
Major depression 38
Endometrial cancer 38
Psoriatic arthropathy 37
Overweight 36
Myelodysplastic syndrome 36
Glioblastoma 36
Transitional cell carcinoma 36
Cardiac failure 35
Diffuse large B-cell lymphoma 35
Hormone receptor positive breast cancer 33
Systemic scleroderma 33
Schizophrenia 32
Type 1 diabetes mellitus 32
COVID-19 32
Cholangiocarcinoma 32
Prostate cancer metastatic 31
Head and neck cancer 31
Hidradenitis 31
HER2 positive breast cancer 30
Adenocarcinoma pancreas 30
Myasthenia gravis 30
Cervix carcinoma 29
Coronary artery disease 29
Acute lymphocytic leukaemia 29
Renal cell carcinoma 29
Rectal cancer 29
Pulmonary arterial hypertension 28
Follicular lymphoma 28
Plasma cell myeloma refractory 28
Pancreatic carcinoma metastatic 27
Oesophageal carcinoma 27
Depression 27
Bladder transitional cell carcinoma 27
Adenocarcinoma gastric 26
Pneumonia 26
Procedural pain 25
Interstitial lung disease 25
Metastatic malignant melanoma 25
B-cell lymphoma 25
Acute myocardial infarction 25
Idiopathic pulmonary fibrosis 24
Myelofibrosis 24
Non-small cell lung cancer stage III 24
Colon cancer 24
Amyotrophic lateral sclerosis 24
Non-small cell lung cancer stage IIIB 24
Fallopian tube cancer 23
Small cell lung cancer 23
Breast cancer female 23
Sjogren’s syndrome 23
B-cell small lymphocytic lymphoma 22
Soft tissue sarcoma 22
Cardiac amyloidosis 22
Lung neoplasm malignant 22
Sepsis 22
Small cell lung cancer extensive stage 22

Diseases starting with u

  • 1

    Ulcerative keratitis

    Ulcerative keratitis is a serious inflammatory eye condition that causes painful sores and tissue breakdown in the cornea, requiring immediate medical attention to prevent vision loss and, in some cases, life-threatening complications.

  • 1

    Underweight

    Being underweight means your body weight falls below the healthy range needed for your body to function properly. This can lead to various health problems, from weakened bones to fertility issues, and may require medical attention to address underlying causes and restore healthy weight.

  • 0

    Undifferentiated sarcoma

    Undifferentiated sarcoma is a rare type of cancer that develops in the body’s connective tissues, often affecting the arms, legs, or abdomen. This aggressive disease requires prompt diagnosis and a combination of treatments to give patients the best chance of recovery.

  • 1

    Univentricular heart

    Univentricular heart is a group of serious heart conditions present at birth where only one of the heart’s two pumping chambers can work properly to support the body’s blood circulation.

  • 2

    Upper limb fracture

    An upper limb fracture occurs when one of the bones in your arm breaks, from your shoulder down to your hand and fingers. These breaks can range from small cracks to bones broken into multiple pieces, and while they’re often caused by serious accidents, proper treatment can help restore full function of your arm.

  • 1

    Upper respiratory tract infection

    Upper respiratory tract infections are among the most common illnesses worldwide, affecting millions of people every year. While these infections can be uncomfortable and disrupt daily life, most are caused by viruses and resolve on their own with proper care and rest.

  • 2

    Urea cycle disorder

    Urea cycle disorder is a group of rare genetic conditions that prevent the body from removing toxic ammonia from the blood. When ammonia builds up, it can cause serious brain damage and affect organ function, making these disorders life-threatening without proper treatment.

  • 0

    Ureteric cancer

    Ureteric cancer is a rare type of cancer that develops in the ureters, the tubes that carry urine from the kidneys to the bladder. Though uncommon, it most often affects older adults and is closely linked to bladder cancer, requiring careful monitoring and specialized treatment.

  • 1

    Urethral stenosis

    Urethral stenosis, also called urethral stricture, is a narrowing of the tube that carries urine out of your body. This narrowing makes it difficult and sometimes painful to urinate, and without treatment, it can lead to serious complications affecting your bladder and kidneys.

  • 2

    Urethral valves

    Urethral valves are a birth defect affecting only boys, where extra flaps of tissue block the tube that carries urine out of the body, potentially causing serious damage to the bladder and kidneys if left untreated.

  • 5

    Urinary incontinence

    Urinary incontinence, the involuntary loss of bladder control, affects millions of people worldwide, yet many suffer in silence due to embarrassment. While it becomes more common with age, it is not an inevitable part of getting older, and effective treatments are available to help you regain control and improve your quality of life.

  • 14

    Urinary tract infection

    Urinary tract infections are among the most common bacterial infections people experience, affecting millions each year. While these infections can be uncomfortable and disruptive, understanding the symptoms, causes, and treatment options can help you recognize when to seek care and how to reduce your risk.

  • 1

    Urticaria

    Urticaria, commonly known as hives, affects about 20 percent of people at some time during their lives, causing intensely itchy, raised welts that appear suddenly and can last from minutes to months or even years.

  • 1

    Urticaria cholinergic

    Cholinergic urticaria causes small, itchy bumps to appear on your skin when your body temperature rises and you start to sweat, triggered by activities like exercise, hot showers, stress, or even eating spicy foods.

  • 5

    Urticaria chronic

    Chronic urticaria is a condition where itchy, raised welts appear on your skin at least twice per week for more than six weeks. For many people, the cause remains unknown, but treatments can help control symptoms and improve quality of life.

  • 2

    Usher’s syndrome

    Usher’s syndrome is a rare genetic condition that affects both hearing and vision, and is the most common cause of combined deafness and blindness.

  • 0

    Uterine cancer

    Uterine cancer is a disease in which cells in the uterus grow out of control. It is the most common cancer affecting the female reproductive system, and while it can be serious, many cases can be cured when detected early.

  • 2

    Uterine leiomyoma

    Uterine leiomyoma, commonly known as fibroids, are noncancerous growths that develop in or on the uterus and affect millions of women during their reproductive years. While many women experience no symptoms, others face significant challenges including heavy bleeding, pain, and complications affecting their quality of life.

  • 1

    Uterine leiomyosarcoma

    Uterine leiomyosarcoma is a rare and aggressive cancer that develops in the muscle wall of the uterus, accounting for only 2% to 5% of all uterine cancers. Despite often being discovered in early stages, this challenging disease requires specialized treatment and long-term monitoring.

  • 12

    Uveal melanoma

    Uveal melanoma is the most common type of eye cancer in adults, yet it remains a rare disease affecting only about 5 people per million each year. Though small tumors can often be treated while preserving vision, this cancer carries a significant risk of spreading to other organs, making early detection and expert care essential.

  • 7

    Uveitis

    Uveitis is inflammation inside the eye that can cause pain, redness, and vision problems. While it affects millions of people worldwide each year, early diagnosis and treatment can prevent serious complications, including permanent vision loss.