Explore popular diseases in clinical trials

Check which popular diseases are currently being frequently studied.

See also our rare diseases glossary and drug database.

Starting by letter

To open the diseases glossary, select a letter from the list below.

Most popular diseases

The list below features the most popular diseases currently involved in ongoing clinical trials.

Disease Trials
Non-small cell lung cancer 231
Breast cancer 125
Neoplasm 123
Plasma cell myeloma 120
Acute myeloid leukaemia 107
Neoplasm malignant 92
Colitis ulcerative 86
Prostate cancer 85
Obesity 84
Colorectal cancer metastatic 82
Ovarian cancer 72
Colorectal cancer 71
Crohn’s disease 69
Dementia Alzheimer’s type 69
Type 2 diabetes mellitus 68
Dermatitis atopic 62
Hepatocellular carcinoma 62
Malignant melanoma 61
Non-small cell lung cancer metastatic 61
Breast cancer metastatic 60
Triple negative breast cancer 60
Asthma 59
HIV infection 58
Rheumatoid arthritis 56
Hormone receptor positive HER2 negative breast cancer 54
Osteoarthritis 54
Chronic lymphocytic leukaemia 52
Renal transplant 52
Chronic kidney disease 51
Squamous cell carcinoma of head and neck 50
Pancreatic carcinoma 48
Parkinson’s disease 45
Atrial fibrillation 45
Ischaemic stroke 44
Oesophageal adenocarcinoma 43
Psoriasis 43
Systemic lupus erythematosus 43
Gastric cancer 43
Multiple sclerosis 42
Endometrial cancer 40
Hormone-refractory prostate cancer 40
Major depression 39
Diffuse large B-cell lymphoma 38
Bladder cancer 38
Non-small cell lung cancer stage IV 37
Chronic obstructive pulmonary disease 37
Overweight 37
Migraine 36
Myelodysplastic syndrome 36
Cardiac failure 36
Glioblastoma 35
Hidradenitis 35
Transitional cell carcinoma 35
Psoriatic arthropathy 34
Acute lymphocytic leukaemia 32
Type 1 diabetes mellitus 32
Hormone receptor positive breast cancer 32
Cholangiocarcinoma 31
COVID-19 31
Bladder transitional cell carcinoma 30
Systemic scleroderma 30
Schizophrenia 30
Myasthenia gravis 29
Renal cell carcinoma 29
Prostate cancer metastatic 29
Oesophageal carcinoma 28
Coronary artery disease 28
Pneumonia 28
Plasma cell myeloma refractory 28
Head and neck cancer 28
HER2 positive breast cancer 28
Cervix carcinoma 27
Follicular lymphoma 27
Adenocarcinoma pancreas 27
Procedural pain 26
Adenocarcinoma gastric 26
Rectal cancer 26
Depression 26
Non-small cell lung cancer stage III 26
Interstitial lung disease 25
Small cell lung cancer extensive stage 25
Pancreatic carcinoma metastatic 25
Fallopian tube cancer 25
Metastatic malignant melanoma 25
Non-small cell lung cancer stage IIIB 24
Myelofibrosis 24
Idiopathic pulmonary fibrosis 24
Colon cancer 24
Pulmonary arterial hypertension 23
Sepsis 23
B-cell lymphoma 23
Soft tissue sarcoma 22
Sjogren’s syndrome 22
Lung neoplasm malignant 21
Mantle cell lymphoma 21
Neovascular age-related macular degeneration 21
Cardiac amyloidosis 21
Breast cancer female 21
Endocrine ophthalmopathy 21
Gastrooesophageal cancer 21

Diseases starting with u

  • 1

    Ulcerative keratitis

    Ulcerative keratitis is a serious inflammatory eye condition that causes painful sores and tissue breakdown in the cornea, requiring immediate medical attention to prevent vision loss and, in some cases, life-threatening complications.

  • 1

    Underweight

    Being underweight means your body weight falls below the healthy range needed for your body to function properly. This can lead to various health problems, from weakened bones to fertility issues, and may require medical attention to address underlying causes and restore healthy weight.

  • 0

    Undifferentiated sarcoma

    Undifferentiated sarcoma is a rare type of cancer that develops in the body’s connective tissues, often affecting the arms, legs, or abdomen. This aggressive disease requires prompt diagnosis and a combination of treatments to give patients the best chance of recovery.

  • 1

    Univentricular heart

    Univentricular heart is a group of serious heart conditions present at birth where only one of the heart’s two pumping chambers can work properly to support the body’s blood circulation.

  • 2

    Upper limb fracture

    An upper limb fracture occurs when one of the bones in your arm breaks, from your shoulder down to your hand and fingers. These breaks can range from small cracks to bones broken into multiple pieces, and while they’re often caused by serious accidents, proper treatment can help restore full function of your arm.

  • 1

    Upper respiratory tract infection

    Upper respiratory tract infections are among the most common illnesses worldwide, affecting millions of people every year. While these infections can be uncomfortable and disrupt daily life, most are caused by viruses and resolve on their own with proper care and rest.

  • 2

    Urea cycle disorder

    Urea cycle disorder is a group of rare genetic conditions that prevent the body from removing toxic ammonia from the blood. When ammonia builds up, it can cause serious brain damage and affect organ function, making these disorders life-threatening without proper treatment.

  • 0

    Ureteric cancer

    Ureteric cancer is a rare type of cancer that develops in the ureters, the tubes that carry urine from the kidneys to the bladder. Though uncommon, it most often affects older adults and is closely linked to bladder cancer, requiring careful monitoring and specialized treatment.

  • 1

    Urethral stenosis

    Urethral stenosis, also called urethral stricture, is a narrowing of the tube that carries urine out of your body. This narrowing makes it difficult and sometimes painful to urinate, and without treatment, it can lead to serious complications affecting your bladder and kidneys.

  • 2

    Urethral valves

    Urethral valves are a birth defect affecting only boys, where extra flaps of tissue block the tube that carries urine out of the body, potentially causing serious damage to the bladder and kidneys if left untreated.

  • 5

    Urinary incontinence

    Urinary incontinence, the involuntary loss of bladder control, affects millions of people worldwide, yet many suffer in silence due to embarrassment. While it becomes more common with age, it is not an inevitable part of getting older, and effective treatments are available to help you regain control and improve your quality of life.

  • 14

    Urinary tract infection

    Urinary tract infections are among the most common bacterial infections people experience, affecting millions each year. While these infections can be uncomfortable and disruptive, understanding the symptoms, causes, and treatment options can help you recognize when to seek care and how to reduce your risk.

  • 1

    Urticaria

    Urticaria, commonly known as hives, affects about 20 percent of people at some time during their lives, causing intensely itchy, raised welts that appear suddenly and can last from minutes to months or even years.

  • 1

    Urticaria cholinergic

    Cholinergic urticaria causes small, itchy bumps to appear on your skin when your body temperature rises and you start to sweat, triggered by activities like exercise, hot showers, stress, or even eating spicy foods.

  • 4

    Urticaria chronic

    Chronic urticaria is a condition where itchy, raised welts appear on your skin at least twice per week for more than six weeks. For many people, the cause remains unknown, but treatments can help control symptoms and improve quality of life.

  • 2

    Usher’s syndrome

    Usher’s syndrome is a rare genetic condition that affects both hearing and vision, and is the most common cause of combined deafness and blindness.

  • 0

    Uterine cancer

    Uterine cancer is a disease in which cells in the uterus grow out of control. It is the most common cancer affecting the female reproductive system, and while it can be serious, many cases can be cured when detected early.

  • 2

    Uterine leiomyoma

    Uterine leiomyoma, commonly known as fibroids, are noncancerous growths that develop in or on the uterus and affect millions of women during their reproductive years. While many women experience no symptoms, others face significant challenges including heavy bleeding, pain, and complications affecting their quality of life.

  • 1

    Uterine leiomyosarcoma

    Uterine leiomyosarcoma is a rare and aggressive cancer that develops in the muscle wall of the uterus, accounting for only 2% to 5% of all uterine cancers. Despite often being discovered in early stages, this challenging disease requires specialized treatment and long-term monitoring.

  • 10

    Uveal melanoma

    Uveal melanoma is the most common type of eye cancer in adults, yet it remains a rare disease affecting only about 5 people per million each year. Though small tumors can often be treated while preserving vision, this cancer carries a significant risk of spreading to other organs, making early detection and expert care essential.

  • 8

    Uveitis

    Uveitis is inflammation inside the eye that can cause pain, redness, and vision problems. While it affects millions of people worldwide each year, early diagnosis and treatment can prevent serious complications, including permanent vision loss.