Explore popular diseases in clinical trials

Check which popular diseases are currently being frequently studied.

See also our rare diseases glossary and drug database.

Starting by letter

To open the diseases glossary, select a letter from the list below.

Most popular diseases

The list below features the most popular diseases currently involved in ongoing clinical trials.

Disease trials
Non-small cell lung cancer 240
Breast cancer 99
Obesity 92
Prostate cancer 77
Colorectal cancer 69
Ovarian cancer 68
Crohn’s disease 67
Non-small cell lung cancer metastatic 64
Rheumatoid arthritis 55
Squamous cell carcinoma of head and neck 54
Triple negative breast cancer 54
Chronic kidney disease 50
Asthma 50
Hepatocellular carcinoma 47
Neoplasm 47
Acute myeloid leukaemia 47
Colorectal cancer metastatic 46
Overweight 45
Multiple sclerosis 43
Colitis ulcerative 40
Parkinson’s disease 40
HER2 positive breast cancer 39
Gastric cancer 38
Myelodysplastic syndrome 38
Dementia Alzheimer’s type 37
Glioblastoma 36
Bladder cancer 34
Atrial fibrillation 34
Prostate cancer metastatic 34
Renal transplant 33
Ischaemic stroke 33
Diffuse large B-cell lymphoma 32
Chronic obstructive pulmonary disease 32
Head and neck cancer 32
Non-small cell lung cancer stage IV 31
Breast cancer metastatic 30
Coronary artery disease 29
Myasthenia gravis 29
Malignant melanoma 29
Endometrial cancer 28
Cholangiocarcinoma 28
Rectal cancer 27
Pulmonary arterial hypertension 27
Dermatitis atopic 27
Idiopathic pulmonary fibrosis 27
Soft tissue sarcoma 26
Non-small cell lung cancer stage III 26
Plasma cell myeloma 25
Pancreatic carcinoma 25
Small cell lung cancer extensive stage 25
Sepsis 25
Renal cell carcinoma 25
Schizophrenia 24
COVID-19 24
Duchenne muscular dystrophy 24
Non-small cell lung cancer stage IIIB 24
Follicular lymphoma 24
Hormone receptor positive breast cancer 24
Fallopian tube cancer 23
Amyotrophic lateral sclerosis 23
Mantle cell lymphoma 23
Influenza 22
Neoplasm malignant 22
Chronic lymphocytic leukaemia 21
Acute myocardial infarction 21
Major depression 21
Small cell lung cancer 21
Sickle cell disease 21
Interstitial lung disease 21
Cystic fibrosis 21
Breast cancer female 20
Osteoarthritis 20
Glioma 20
Neuroblastoma 20
Chronic rhinosinusitis with nasal polyps 20
Oesophageal adenocarcinoma 20
Myelofibrosis 19
B-cell lymphoma 19
Critical illness 18
Procedural pain 18
Acute kidney injury 18
Psoriasis 18
Axial spondyloarthritis 18
Acute coronary syndrome 17
Vitiligo 17
Hereditary angioedema 17
Relapsing-remitting multiple sclerosis 17
Ewing’s sarcoma 17
IgA nephropathy 17
Gastrooesophageal cancer 16
Juvenile idiopathic arthritis 16
Cardiac failure 16
Uveal melanoma 16
Chronic hepatitis B 16
Allogenic stem cell transplantation 15
Giant cell arteritis 15
Chronic spontaneous urticaria 15
Cardiac arrest 15
Septic shock 14
Malignant melanoma stage III 14

All diseases

  • 19

    B-cell lymphoma

    B-cell lymphoma is a type of blood cancer that develops in the lymphatic system, where abnormal white blood cells multiply to form tumors throughout the body. While some types can grow quickly, many can be successfully treated and even cured with modern therapies.

  • 3

    B-cell lymphoma recurrent

    When B-cell lymphoma returns after successful treatment, it presents new challenges that require specialized care and treatment approaches to manage the disease effectively.

  • 10

    B-cell lymphoma refractory

    When lymphoma does not respond well to treatment or returns after a period of improvement, patients face a challenging situation that requires specialized care and new treatment approaches.

  • 11

    B-cell small lymphocytic lymphoma

    B-cell small lymphocytic lymphoma is a slow-growing blood cancer that affects the lymphatic system. Many people live with this condition for years without symptoms, and when treatment is needed, there are effective options available to help manage the disease and maintain quality of life.

  • 9

    B-cell type acute leukaemia

    B-cell acute lymphoblastic leukaemia is a fast-growing blood cancer that primarily affects children, but adults can develop it too. With proper treatment, particularly in children, cure rates can be remarkably high.

  • 2

    B-cell unclassifiable lymphoma high grade

    B-cell unclassifiable lymphoma high grade is an aggressive form of blood cancer that poses unique challenges for both diagnosis and treatment, requiring specialized approaches that differ from other types of lymphoma.

  • 8

    Back pain

    Back pain affects eight out of ten people at some point in their lives and is one of the most common reasons people seek medical care, yet most cases improve with simple home treatments and lifestyle changes.

  • 0

    Bacteraemia

    Bacteraemia occurs when bacteria enter the bloodstream, which is normally sterile and free from germs. While healthy people often clear these bacteria without symptoms, the condition can become serious if the immune system cannot cope, potentially leading to life-threatening complications.

  • 10

    Bacterial infection

    Bacterial infections are illnesses caused by tiny single-celled organisms that enter and multiply in your body. While most bacteria around us are harmless or even helpful, some can cause diseases ranging from minor skin problems to life-threatening conditions affecting the blood, lungs, or brain.

  • 3

    Bacterial prostatitis

    Bacterial prostatitis is an infection of the prostate gland caused by bacteria that can appear suddenly or develop gradually over time, causing pain, urinary problems, and sometimes flu-like symptoms that require proper medical treatment.

  • 4

    Bacterial vaginosis

    Bacterial vaginosis is the most common vaginal condition affecting women of reproductive age worldwide, yet many people with this infection don’t even realize they have it. Understanding what causes this imbalance and how to treat it can help prevent uncomfortable symptoms and reduce the risk of more serious health complications.

  • 3

    Barrett’s oesophagus

    Barrett’s oesophagus is a condition where the cells lining the lower part of your food pipe change structure after long-term exposure to stomach acid, creating a small but important risk factor that requires regular medical monitoring.

  • 1

    Bartonellosis

    Bartonellosis is a group of infectious diseases caused by bacteria that can spread to humans through cat scratches, flea bites, body lice, or sand fly bites. These infections range from mild illness that goes away on its own to severe complications affecting the heart, brain, and other organs.

  • 9

    Basal cell carcinoma

    Basal cell carcinoma is the most common form of skin cancer, affecting millions of people each year. While it rarely spreads to other parts of the body, early detection and treatment are essential to prevent local tissue damage and disfigurement.

  • 0

    Basal cell naevus syndrome

    Basal cell naevus syndrome is a rare inherited condition that causes multiple skin cancers to develop from a young age, along with cysts in the jaw and other abnormalities throughout the body.

  • 2

    Becker’s muscular dystrophy

    Becker muscular dystrophy is a rare inherited condition that causes progressive muscle weakness, primarily affecting the hips, thighs, shoulders, and heart. Though there is currently no cure, understanding the disease and working with a specialized care team can help maintain muscle function and improve quality of life.

  • 1

    Behavioural addiction

    Behavioural addiction is a chronic condition where a person compulsively engages in rewarding activities despite harmful consequences to their physical health, mental wellbeing, relationships, and finances—creating a cycle that can be just as challenging as substance addiction.

  • 2

    Behcet’s syndrome

    Behcet’s syndrome is a rare condition that causes inflammation of blood vessels throughout the body, leading to painful mouth sores, genital ulcers, eye problems, and many other symptoms that can come and go unpredictably.

  • 0

    Benign neoplasm of cervix uteri

    A benign neoplasm of the cervix uteri is a non-cancerous growth that develops on the cervix, the lower part of the uterus that connects to the vagina. These growths do not spread to other parts of the body and are not usually life-threatening.

  • 0

    Benign neoplasm of thyroid gland

    Most lumps found in the thyroid gland are not cancerous. These benign growths, called thyroid nodules or thyroid adenomas, are very common and usually don’t cause any symptoms, though they can sometimes grow large enough to affect breathing or swallowing.

  • 1

    Benign neoplasm of ureter

    Benign tumors of the ureter are rare growths that develop in the tubes connecting your kidneys to your bladder. Unlike cancerous tumors, these growths don’t spread to other parts of the body, but they can still cause significant problems with urine flow and kidney function.

  • 2

    Benign prostatic hyperplasia

    Benign prostatic hyperplasia is a common condition that affects most men as they age, causing the prostate gland to grow larger and potentially leading to bothersome urinary symptoms, though it is not cancerous and does not increase the risk of prostate cancer.

  • 1

    Benign renal neoplasm

    A benign kidney tumor is a growth in the kidney that does not spread to other parts of the body and is not usually life-threatening, though it can sometimes cause symptoms that need treatment.

  • 0

    Beta haemolytic streptococcal infection

    Beta haemolytic streptococcal infections are caused by bacteria that can lead to illnesses ranging from a simple sore throat to severe, life-threatening conditions affecting multiple organs.

  • 1

    Bile acid synthesis disorder

    Bile acid synthesis disorders are rare genetic conditions that disrupt the body’s ability to produce normal bile acids, leading to serious liver problems and other complications that can affect people from infancy through adulthood.

  • 0

    Bile duct adenocarcinoma

    Bile duct adenocarcinoma, also called cholangiocarcinoma, is a rare and aggressive form of cancer that starts in the thin tubes carrying bile from your liver and gallbladder to your small intestine. Most people are diagnosed after the cancer has already spread, making it difficult to treat, but ongoing research continues to improve treatment options and outcomes.

  • 2

    Bile duct cancer

    Bile duct cancer is a rare but aggressive form of cancer that develops in the thin tubes connecting your liver, gallbladder, and small intestine. Often diagnosed at advanced stages when treatment is challenging, this disease requires specialized care and a comprehensive understanding of available options.

  • 1

    Biliary adenoma

    Biliary adenoma is a rare, noncancerous growth that develops from the cells that line the bile ducts inside or near the liver. These small tumors are usually discovered by accident during surgery or imaging tests for other reasons, and while they generally don’t cause problems, they require careful evaluation to distinguish them from more serious conditions.

  • 4

    Biliary cancer metastatic

    Biliary cancer metastatic, also known as metastatic cholangiocarcinoma, occurs when cancer cells that began in the bile ducts have spread to distant parts of the body. Most people with bile duct cancer are diagnosed when the disease has already advanced beyond the bile ducts, making treatment more challenging.

  • 4

    Biliary neoplasm

    Biliary neoplasms are tumors that develop in the bile ducts or gallbladder, affecting the system responsible for carrying digestive fluid from the liver to the small intestine. While most of these tumors are cancerous, understanding their characteristics and treatment options is essential for patients facing this diagnosis.

  • 0

    Biliary tract disorder

    Biliary tract disorders affect the network of organs and tubes that produce, store, and transport bile—a digestive fluid made by your liver. These conditions can range from common problems like gallstones to more complex inflammatory diseases, and understanding them is key to getting the right treatment and living well.

  • 1

    Biliary tract operation

    Biliary tract operations are surgical procedures that address problems affecting the bile ducts, gallbladder, and liver—organs essential for digestion. These surgeries help restore normal function when conditions like gallstones, blockages, or tumors disrupt the flow of bile.

  • 2

    Binge eating

    Binge eating disorder is the most common eating disorder in the United States, affecting nearly 30 million Americans in their lifetimes, yet many people don’t realize it’s a serious medical condition that requires professional treatment.

  • 0

    Biopsy heart

    A heart biopsy is a medical test that removes tiny samples of heart muscle tissue for examination under a microscope. This test plays a vital role in monitoring heart transplant patients and diagnosing various heart conditions that affect the heart muscle.

  • 1

    Biotinidase deficiency

    Biotinidase deficiency is a treatable inherited disorder where the body cannot recycle biotin, a vital vitamin needed for breaking down food into energy. Early diagnosis and simple daily treatment with biotin supplements can prevent serious health problems and allow children to develop normally.

  • 10

    Bipolar disorder

    Bipolar disorder is a lifelong mental health condition that causes extreme mood swings, from emotional highs called mania to lows known as depression. Although it cannot be cured, it can be managed effectively with the right treatment and lifestyle changes.

  • 1

    Bipolar I disorder

    Bipolar I disorder is a serious mental health condition that causes extreme shifts in mood, energy, and behavior, involving intense manic episodes that can disrupt every aspect of daily life.

  • 0

    BK virus infection

    BK virus infection is a common childhood virus that usually stays dormant in the body for life, but can reactivate in people with weakened immune systems, particularly kidney and bone marrow transplant recipients, potentially causing serious complications to the transplanted organ.

  • 34

    Bladder cancer

    Bladder cancer occurs when cells in the bladder start to grow without control, forming tumors in the organ that stores urine. While it’s the sixth most common cancer in the United States and fourth most common in men, most cases are caught early and are treatable, though the disease often comes back after treatment.

  • 0

    Bladder cancer recurrent

    Bladder cancer has one of the highest recurrence rates among all cancers, making ongoing surveillance essential even after successful treatment. Understanding why the cancer can return and what steps to take can help patients and their families navigate this challenging journey.

  • 0

    Bladder cancer stage 0 with cancer in situ

    Stage 0 bladder cancer with carcinoma in situ is the earliest form of bladder cancer, where cancer cells remain in the inner lining of the bladder and haven’t spread deeper into the bladder wall or to other parts of the body.

  • 0

    Bladder cancer stage I with cancer in situ

    Stage I bladder cancer with carcinoma in situ is an early but aggressive form of bladder cancer that requires careful treatment and monitoring, as it has a higher risk of returning or spreading compared to other early-stage cancers.

  • 1

    Bladder cancer stage II

    Stage 2 bladder cancer is a form of muscle-invasive bladder cancer where cancer cells have grown through the connective tissue layer into the muscle wall of the bladder, but have not spread to lymph nodes or other parts of the body.

  • 1

    Bladder cancer stage III

    Stage 3 bladder cancer is considered a locally advanced form of the disease, where cancerous tissue has grown beyond the bladder muscle and into surrounding tissues. Though advanced, this stage can be successfully treated with surgery, chemotherapy, or radiation therapy.

  • 12

    Bladder transitional cell carcinoma

    Bladder transitional cell carcinoma is a type of cancer that begins in the cells lining the bladder and other parts of the urinary system. While it accounts for about 90% of bladder cancer cases, when detected early, it can be treated successfully—though it frequently returns even after treatment.

  • 0

    Bladder transitional cell carcinoma recurrent

    Bladder transitional cell carcinoma has a notable tendency to return after treatment, making recurrence one of the most challenging aspects of this disease. Understanding how to manage and monitor for cancer that comes back is essential for anyone who has been treated for this condition.

  • 0

    Bladder transitional cell carcinoma stage 0

    Stage 0 bladder cancer is the earliest form of bladder cancer, where cancer cells are found only in the innermost lining of the bladder and have not grown deeper into the bladder wall. When caught at this stage, the cancer is highly treatable, though it has a tendency to come back.

  • 0

    Bladder transitional cell carcinoma stage I

    Stage I bladder transitional cell carcinoma is an early form of bladder cancer where the disease has begun to grow into the connective tissue beneath the bladder lining but has not yet reached the muscle wall. Caught at this stage, the cancer is treatable, though it has a tendency to return.

  • 1

    Bladder transitional cell carcinoma stage II

    Stage II bladder cancer is a serious form of cancer where abnormal cells have invaded the muscle wall of the bladder. This type of cancer requires prompt treatment but can be managed effectively with surgery, chemotherapy, or a combination of approaches.

  • 1

    Bladder transitional cell carcinoma stage III

    Stage 3 bladder transitional cell carcinoma is an advanced form of cancer where the disease has grown through the muscle layer of the bladder into surrounding tissues, but has not yet spread to distant parts of the body. Though advanced, this stage can be successfully treated with several options available.

  • 0

    Bladder transitional cell carcinoma stage IV

    Stage IV bladder transitional cell carcinoma is the most advanced form of cancer that begins in the cells lining the bladder, spreading beyond the bladder to lymph nodes or distant organs. While this diagnosis is serious, treatment options are available to help control symptoms, slow disease progression, and improve quality of life.

  • 2

    Blastic plasmacytoid dendritic cell neoplasia

    Blastic plasmacytoid dendritic cell neoplasm is a rare and aggressive blood cancer that often appears first as skin lesions, affecting fewer than 1,000 people each year in the United States, with new treatments now offering hope for patients with this challenging disease.

  • 0

    Blood disorder

    Blood disorders are conditions that prevent parts of your blood from doing their essential jobs, such as carrying oxygen, fighting infections, or helping your blood clot properly. While some blood disorders can be serious, many can be managed with proper treatment and care.

  • 1

    Blood iron increased

    When your body absorbs and stores too much iron from food, it can damage vital organs over time. This condition, known as iron overload or hemochromatosis, affects how your body handles an essential mineral that’s normally needed for healthy blood and energy.

  • 0

    Body mass index increased

    Body Mass Index (BMI) is a simple measure that uses your height and weight to estimate body fat, but it’s important to understand what it means for your health and how to interpret it alongside other factors.

  • 1

    Bone hypertrophy

    Bone hypertrophy is a condition where bones grow abnormally large and thick, causing pain and limited movement. Understanding its causes, symptoms, and available treatments can help those affected manage this challenging condition.

  • 0

    Bone marrow disorder

    Bone marrow disorders occur when the spongy tissue inside your bones, which produces vital blood cells, stops working properly or develops problems with the stem cells that create red blood cells, white blood cells, and platelets.

  • 1

    Bone marrow failure

    Bone marrow failure happens when the soft, spongy tissue inside your bones stops making enough healthy blood cells your body needs to function properly. This rare condition can develop at any age and requires specialized medical care, but many people manage it successfully with modern treatments.

  • 0

    Bone metabolism disorder

    Bone metabolism disorders are a group of conditions that weaken your bones by disrupting the balance of minerals like calcium, phosphorus, and vitamin D. While some people are born with these disorders, others develop them later in life due to lifestyle factors, medical conditions, or medications.

  • 2

    Bone sarcoma

    Bone sarcoma is a rare type of cancer that starts in the bones themselves, affecting fewer than 1% of all cancer diagnoses, yet carrying significant challenges for those who face it.