Explore popular diseases in clinical trials

Check which popular diseases are currently being frequently studied.

See also our rare diseases glossary and drug database.

Starting by letter

To open the diseases glossary, select a letter from the list below.

Most popular diseases

The list below features the most popular diseases currently involved in ongoing clinical trials.

Disease trials
Non-small cell lung cancer 228
Breast cancer 94
Obesity 86
Prostate cancer 73
Colorectal cancer 69
Ovarian cancer 66
Non-small cell lung cancer metastatic 66
Crohn’s disease 61
Type 2 diabetes mellitus 54
Rheumatoid arthritis 54
Triple negative breast cancer 52
Hormone receptor positive HER2 negative breast cancer 52
Asthma 51
Acute myeloid leukaemia 50
Squamous cell carcinoma of head and neck 50
Chronic kidney disease 49
Neoplasm 48
Colorectal cancer metastatic 47
Hepatocellular carcinoma 47
Systemic lupus erythematosus 40
Colitis ulcerative 40
Multiple sclerosis 39
Overweight 39
Dementia Alzheimer’s type 39
Gastric cancer 38
Myelodysplastic syndrome 37
Parkinson’s disease 37
HER2 positive breast cancer 37
Glioblastoma 37
Atrial fibrillation 34
Bladder cancer 34
Chronic obstructive pulmonary disease 33
Ischaemic stroke 33
Prostate cancer metastatic 33
Myasthenia gravis 32
Renal transplant 31
Type 1 diabetes mellitus 31
Head and neck cancer 31
Endometrial cancer 31
Malignant melanoma 31
Non-small cell lung cancer stage IV 31
Diffuse large B-cell lymphoma 31
Breast cancer metastatic 31
HIV infection 30
Dermatitis atopic 28
Cholangiocarcinoma 28
Coronary artery disease 28
Plasma cell myeloma 28
Pulmonary arterial hypertension 28
Neoplasm malignant 27
Rectal cancer 27
Renal cell carcinoma 26
Pancreatic carcinoma 26
Schizophrenia 26
Duchenne muscular dystrophy 25
Non-small cell lung cancer stage III 25
Follicular lymphoma 25
COVID-19 25
Migraine 24
Hormone receptor positive breast cancer 24
Idiopathic pulmonary fibrosis 24
Non-small cell lung cancer stage IIIB 24
Sepsis 24
Chronic lymphocytic leukaemia 24
Soft tissue sarcoma 24
Mantle cell lymphoma 23
Small cell lung cancer extensive stage 23
Colon cancer 23
Fallopian tube cancer 23
Influenza 22
Small cell lung cancer 21
Interstitial lung disease 21
Acute myocardial infarction 21
Oesophageal adenocarcinoma 21
Amyotrophic lateral sclerosis 21
Chronic rhinosinusitis with nasal polyps 20
Cystic fibrosis 20
Glioma 20
Myelofibrosis 19
Neuroblastoma 19
B-cell lymphoma 19
Sickle cell disease 19
Major depression 19
Procedural pain 19
Axial spondyloarthritis 18
Osteoarthritis 18
Breast cancer female 17
Critical illness 17
Acute kidney injury 17
Hereditary angioedema 17
Relapsing-remitting multiple sclerosis 16
Acute coronary syndrome 16
IgA nephropathy 16
Psoriasis 16
Gastrooesophageal cancer 16
Ewing’s sarcoma 16
Cardiac failure 16
Vitiligo 16
Transitional cell carcinoma 15
Giant cell arteritis 15

Diseases starting with f

  • 7

    Fabry’s disease

    Fabry disease is a rare inherited condition where a specific type of fat builds up in your body’s cells because you lack a crucial enzyme to break it down. This buildup can affect many organs including your heart, kidneys, and nervous system, causing pain, organ damage, and potentially life-threatening complications.

  • 0

    Facial paresis

    Facial paresis is a condition where you lose the ability to move muscles on one or both sides of your face due to damage to the facial nerve. This nerve damage can happen suddenly or develop gradually, affecting your ability to smile, close your eyes, eat, and express emotions.

  • 7

    Facioscapulohumeral muscular dystrophy

    Facioscapulohumeral muscular dystrophy is a genetic disorder that progressively weakens muscles of the face, shoulders, and upper arms, affecting approximately 1 in 8,000 to 20,000 people worldwide and representing the third most common form of muscular dystrophy.

  • 1

    Factor IX deficiency

    Factor IX deficiency, also known as Hemophilia B or Christmas disease, is a rare inherited bleeding disorder where the blood cannot clot properly due to missing or insufficient clotting factor IX protein, affecting mainly males and requiring lifelong management.

  • 4

    Factor VIII deficiency

    Factor VIII deficiency, also known as hemophilia A, is an inherited bleeding disorder that prevents blood from clotting properly. This condition causes prolonged and excessive bleeding either spontaneously or after injuries, making everyday activities and medical procedures potentially dangerous without proper treatment.

  • 23

    Fallopian tube cancer

    Fallopian tube cancer is a rare disease that forms in the tubes connecting the ovaries to the uterus. Often silent in its early stages, this cancer shares many features with ovarian cancer and requires similar treatment approaches.

  • 0

    Fallopian tube cancer metastatic

    Fallopian tube cancer that has spread beyond its original site to other parts of the body presents significant treatment challenges, yet understanding how this rare cancer behaves can help patients and their families navigate the journey ahead.

  • 2

    Fallopian tube cancer stage III

    Stage 3 fallopian tube cancer means the disease has spread beyond the pelvis into the abdominal cavity or to nearby lymph nodes. This advanced stage requires a combination of treatments, and understanding what to expect can help you work with your healthcare team to plan the best approach for your situation.

  • 2

    Fallopian tube cancer stage IV

    Stage IV fallopian tube cancer represents the most advanced form of this disease, where cancer has spread beyond the pelvis and abdomen to distant parts of the body such as the liver, lungs, or distant lymph nodes.

  • 1

    Familial amyotrophic lateral sclerosis

    Familial amyotrophic lateral sclerosis (fALS) is an inherited form of ALS that runs in families, accounting for about 5-10% of all ALS cases. Unlike the more common sporadic form, fALS is caused by genetic mutations passed down from parents to children, often striking at a younger age and offering new hope for targeted gene therapies.

  • 0

    Familial haemophagocytic lymphohistiocytosis

    Familial haemophagocytic lymphohistiocytosis is a rare and life-threatening genetic condition where the immune system, instead of protecting the body, turns against it and attacks healthy organs.

  • 3

    Familial hypertriglyceridaemia

    Familial hypertriglyceridemia is a genetic disorder that causes elevated levels of fats in your blood, increasing your risk of heart disease and, in severe cases, a serious condition affecting your pancreas.

  • 0

    Familial mediterranean fever

    Familial Mediterranean fever is a hereditary condition that causes repeated episodes of fever and painful inflammation in the abdomen, chest, and joints, mainly affecting people of Mediterranean and Middle Eastern origin.

  • 1

    Fatty acid oxidation disorder

    Fatty acid oxidation disorders are inherited conditions that prevent the body from breaking down fats to produce energy, leaving organs without the fuel they need during times of fasting, illness, or physical activity.

  • 2

    Febrile neutropenia

    Febrile neutropenia is a serious medical emergency that occurs when a person with very low white blood cell counts develops a fever, most commonly as a complication of cancer treatment. Without enough infection-fighting cells, even a minor infection can quickly become life-threatening, requiring immediate medical attention.

  • 1

    Femoral hernia

    A femoral hernia is a rare type of hernia that develops in the upper thigh near the groin, occurring when tissue or part of the intestine pushes through a weak spot in the abdominal wall into an area called the femoral canal.

  • 1

    Femoral neck fracture

    A femoral neck fracture is a serious break in the upper part of the thigh bone, near the hip joint. While these fractures are common in older adults after simple falls, they can also occur in younger people following high-impact trauma. Most cases require surgery, and quick diagnosis and treatment are essential to prevent serious complications.

  • 0

    Femur fracture

    A femur fracture is a break in the thighbone, the longest and strongest bone in your body. Because of the femur’s exceptional strength, it usually takes tremendous force to break it, such as a car accident or a serious fall. This injury requires immediate medical attention and typically needs surgery to heal properly.

  • 4

    Fibrodysplasia ossificans progressiva

    Fibrodysplasia ossificans progressiva is an extremely rare genetic condition where muscle tissue and connective tissues like tendons and ligaments gradually turn into bone outside the skeleton, progressively limiting movement and causing severe disability throughout a person’s life.

  • 3

    Fibromyalgia

    Fibromyalgia is a chronic condition that causes widespread pain throughout the body, often accompanied by severe fatigue, sleep problems, and difficulties with memory and concentration. Though there is no cure, a combination of lifestyle changes, medications, and therapy can help manage symptoms and improve quality of life.

  • 1

    Fibrosarcoma

    Fibrosarcoma is a rare type of cancer that begins in the connective tissues of the body, such as tendons and ligaments. Though uncommon, it presents unique challenges depending on whether it affects infants or adults, with the two types behaving very differently.

  • 1

    Fibrosarcoma metastatic

    Fibrosarcoma metastatic is a rare and aggressive soft tissue cancer that has spread from its original location to distant parts of the body, most commonly the lungs, bones, or other organs. This advanced stage of the disease requires prompt diagnosis and specialized treatment to manage its spread and improve patient outcomes.

  • 1

    Fibrous dysplasia of bone

    Fibrous dysplasia of bone is a rare condition where normal, healthy bone tissue is replaced by weaker, scar-like fibrous tissue, making bones fragile and prone to breaking or becoming misshapen.

  • 0

    Fms-like tyrosine kinase 3 positive

    FLT3-positive acute myeloid leukemia is a form of blood cancer that occurs in approximately 30% of adult cases and is associated with a higher risk of the disease returning after treatment.

  • 5

    Focal segmental glomerulosclerosis

    Focal segmental glomerulosclerosis (FSGS) is a serious kidney condition that develops when scar tissue forms in the tiny filtering units of your kidneys, making it difficult for them to remove waste from your blood and potentially leading to kidney failure.

  • 0

    Foetal exposure during pregnancy

    When a pregnant woman is exposed to certain substances or environmental factors, her developing baby can be affected in ways that last a lifetime.

  • 1

    Foetal growth restriction

    Foetal growth restriction is a pregnancy condition where an unborn baby is smaller than expected for how many weeks along the pregnancy is. While some babies are simply small and healthy, others face growth problems that may require close monitoring and early delivery.

  • 1

    Follicle centre lymphoma diffuse small cell lymphoma

    Follicle centre lymphoma diffuse small cell lymphoma is a rare type of cancer that develops from B cells and grows in a diffuse pattern throughout affected tissues. This condition is part of a broader group of lymphomas that originate from follicle center cells, which are specialized white blood cells that normally help fight infections.

  • 1

    Follicle centre lymphoma follicular grade I II – III refractory

    Follicular lymphoma is a type of cancer that affects the lymphatic system, and while it typically grows slowly and responds well to initial treatment, the disease often returns or stops responding to therapy over time, requiring patients and their healthcare teams to navigate new treatment options and considerations.

  • 0

    Follicle centre lymphoma follicular grade I, II – III

    Follicle centre lymphoma, also known as follicular lymphoma, is the most common type of slow-growing non-Hodgkin lymphoma. This cancer develops from abnormal B cells that typically form in clusters within lymph nodes, and while it cannot be cured at present, many people live for years with this condition, often without needing treatment right away.

  • 0

    Follicle centre lymphoma follicular grade I, II – III recurrent

    Follicular lymphoma is a slow-growing blood cancer that frequently returns after treatment, but newer therapies offer hope for longer periods of remission and better quality of life.

  • 24

    Follicular lymphoma

    Follicular lymphoma is a slow-growing cancer that affects white blood cells and is the second most common type of non-Hodgkin lymphoma. While there is currently no cure, many people live for years with this condition, and advances in treatment are helping patients live longer, healthier lives.

  • 1

    Follicular lymphoma stage II

    Follicular lymphoma stage II is an early form of slow-growing blood cancer affecting lymph nodes on the same side of the diaphragm, with treatment options that may lead to long-term remission.

  • 1

    Follicular lymphoma stage III

    Stage III follicular lymphoma is an advanced form of slow-growing cancer where abnormal white blood cells have spread to lymph nodes on both sides of the diaphragm—the muscle separating your chest from your abdomen.

  • 1

    Follicular lymphoma stage IV

    Follicular lymphoma stage IV represents the most advanced stage of this slow-growing blood cancer, where the disease has spread beyond the lymph nodes to organs such as the liver, bone marrow, or lungs. While considered incurable in most cases, many people with stage IV follicular lymphoma can live for extended periods with proper management and treatment.

  • 1

    Follicular thyroid cancer

    Follicular thyroid cancer is the second most common type of thyroid cancer, accounting for about 10 to 15% of all thyroid cancer cases. Despite being classified as a well-differentiated cancer, it is generally more aggressive than papillary thyroid cancer and has a greater tendency to spread through the bloodstream to distant organs. However, with proper treatment, particularly when diagnosed early, follicular thyroid cancer is highly treatable and often curable, with overall cure rates approaching 95%.

  • 1

    Fontan procedure

    The Fontan procedure is a life-changing heart surgery that helps children born with only one working heart chamber survive and grow. This operation, usually performed when children are between 18 months and 5 years old, creates a new pathway for blood to flow through the body, allowing children with complex heart defects to live into adulthood.

  • 3

    Food allergy

    Food allergy affects millions of people worldwide and occurs when the body’s immune system mistakenly treats certain foods as harmful invaders, triggering reactions that can range from mild discomfort to life-threatening emergencies.

  • 0

    Foot deformity

    Foot deformities affect millions of people worldwide, ranging from mild structural changes that cause no problems to severe conditions that make walking difficult and painful. Understanding these conditions and knowing when to seek help can make the difference between managing symptoms conservatively and requiring surgery.

  • 1

    Fracture infection

    When a broken bone becomes infected, recovery can become prolonged and complicated, requiring specialized medical care and sometimes multiple surgeries to heal properly.

  • 2

    Fragile X syndrome

    Fragile X syndrome is the most common inherited cause of intellectual disability and a leading genetic cause of autism. It affects how the brain develops and can impact learning, behavior, and physical features throughout a person’s life.

  • 4

    Friedreich’s ataxia

    Friedreich’s ataxia is a rare inherited disorder that progressively damages the nervous system, affecting movement, balance, and coordination. While symptoms typically begin in childhood or adolescence, the disease’s progression varies greatly from person to person, and advances in care and treatment continue to improve outcomes for those living with this condition.

  • 4

    Frontotemporal dementia

    Frontotemporal dementia is a group of brain diseases that mainly affects the frontal and temporal lobes, causing changes in personality, behavior, language, and sometimes movement. It differs from other forms of dementia because it typically strikes people at a younger age, often between 45 and 65, affecting individuals during their working years and while raising families.

  • 1

    Frostbite

    Frostbite is a serious injury that happens when your skin and the tissues beneath it freeze from exposure to very cold temperatures. This condition can permanently damage your body, and in severe cases, may even require removal of affected body parts like fingers or toes.

  • 1

    Functional gastrointestinal disorder

    Functional gastrointestinal disorders affect approximately 40% of people worldwide, causing chronic digestive symptoms despite the absence of visible structural problems. These conditions, now increasingly understood as disorders of gut-brain interaction, significantly impact quality of life but can be effectively managed through a combination of lifestyle changes, dietary modifications, and medical treatment.

  • 4

    Fungal infection

    Fungal infections affect millions of people worldwide every year, ranging from common skin conditions like athlete’s foot and ringworm to serious internal infections that can be life-threatening for those with weakened immune systems.