Explore popular diseases in clinical trials

Check which popular diseases are currently being frequently studied.

See also our rare diseases glossary and drug database.

Starting by letter

To open the diseases glossary, select a letter from the list below.

Most popular diseases

The list below features the most popular diseases currently involved in ongoing clinical trials.

Disease Trials
Non-small cell lung cancer 264
Breast cancer 134
Plasma cell myeloma 129
Neoplasm 128
Neoplasm malignant 106
Acute myeloid leukaemia 106
Prostate cancer 92
Colitis ulcerative 89
Obesity 86
Colorectal cancer metastatic 85
Colorectal cancer 78
Ovarian cancer 76
Hepatocellular carcinoma 76
Crohn’s disease 73
Dementia Alzheimer’s type 73
Malignant melanoma 73
Breast cancer metastatic 70
Dermatitis atopic 67
Type 2 diabetes mellitus 66
Chronic lymphocytic leukaemia 64
Triple negative breast cancer 64
HIV infection 63
Rheumatoid arthritis 63
Non-small cell lung cancer metastatic 63
Asthma 61
Squamous cell carcinoma of head and neck 61
Osteoarthritis 57
Hormone receptor positive HER2 negative breast cancer 54
Chronic kidney disease 54
Pancreatic carcinoma 52
Renal transplant 51
Systemic lupus erythematosus 48
Multiple sclerosis 47
Hormone-refractory prostate cancer 47
Ischaemic stroke 46
Parkinson’s disease 46
Non-small cell lung cancer stage IV 45
Gastric cancer 44
Chronic obstructive pulmonary disease 44
Atrial fibrillation 43
Bladder cancer 43
Diffuse large B-cell lymphoma 43
Psoriasis 43
Endometrial cancer 41
Oesophageal adenocarcinoma 41
Prostate cancer metastatic 40
Myelodysplastic syndrome 40
Cardiac failure 40
Major depression 39
Psoriatic arthropathy 39
Migraine 38
Glioblastoma 38
Transitional cell carcinoma 38
Type 1 diabetes mellitus 37
Overweight 37
Myasthenia gravis 35
Cholangiocarcinoma 35
Acute lymphocytic leukaemia 35
Hidradenitis 34
COVID-19 34
Schizophrenia 33
Hormone receptor positive breast cancer 33
Plasma cell myeloma refractory 33
HER2 positive breast cancer 33
Systemic scleroderma 32
Head and neck cancer 32
Renal cell carcinoma 32
Adenocarcinoma pancreas 31
Cervix carcinoma 31
Coronary artery disease 30
Non-small cell lung cancer stage III 30
Pulmonary arterial hypertension 30
Depression 30
Rectal cancer 30
Follicular lymphoma 30
Oesophageal carcinoma 29
Pancreatic carcinoma metastatic 29
Metastatic malignant melanoma 29
Bladder transitional cell carcinoma 29
Small cell lung cancer extensive stage 27
Adenocarcinoma gastric 26
Amyotrophic lateral sclerosis 25
Pneumonia 25
Duchenne muscular dystrophy 25
B-cell lymphoma 25
Myelofibrosis 25
Interstitial lung disease 25
Soft tissue sarcoma 25
Endocrine ophthalmopathy 25
Fallopian tube cancer 24
Non-small cell lung cancer stage IIIB 24
Procedural pain 24
Colon cancer 24
Chronic myeloid leukaemia 24
Acute myocardial infarction 24
Lung neoplasm malignant 24
B-cell small lymphocytic lymphoma 24
Sepsis 24
Small cell lung cancer 23
Idiopathic pulmonary fibrosis 23

Diseases starting with l

  • 4

    Labour induction

    Labour induction is a medical procedure where healthcare professionals use medications or other methods to start contractions before they begin naturally, helping to bring about childbirth when continuing pregnancy carries greater risks than delivering the baby.

  • 1

    Labour pain

    Labour pain is one of the most intense physical experiences many women will face, yet it serves a vital purpose – each contraction brings you closer to meeting your baby. Understanding what causes this pain and knowing your options for relief can help you feel more prepared and in control when the time comes.

  • 3

    Langerhans cell sarcoma

    Langerhans cell sarcoma is a rare and aggressive cancer that develops from specialized immune cells called Langerhans cells, which normally help protect the body from infection. Unlike the related but less serious condition called Langerhans cell histiocytosis, this disease shows clearly malignant features and often affects multiple parts of the body.

  • 3

    Langerhans’ cell histiocytosis

    Langerhans’ cell histiocytosis is a rare disorder where a specific type of immune cell builds up in the body, potentially causing tissue damage and tumors in various organs. While it primarily affects children, the disease can occur at any age and ranges from mild conditions that resolve on their own to severe forms requiring intensive treatment.

  • 1

    Laparoscopic surgery

    Laparoscopic surgery is a modern surgical technique that allows doctors to perform procedures through small incisions, offering patients faster recovery times and less pain compared to traditional open surgery.

  • 2

    Laparotomy

    A laparotomy is a major surgical procedure that allows doctors to open the abdomen and examine the organs inside. Whether used to diagnose mysterious symptoms or treat serious conditions, this operation plays a crucial role in modern medicine.

  • 2

    Large cell lung cancer

    Large cell lung cancer is a rare and aggressive form of lung cancer that can develop anywhere in the lungs but grows quickly and tends to spread faster than some other types.

  • 1

    Large cell lung cancer metastatic

    Large cell lung cancer metastatic is a rare and aggressive form of lung cancer that has spread beyond the lungs to other parts of the body. While challenging to treat, advances in therapy have improved outcomes for many patients.

  • 2

    Large cell lung cancer recurrent

    When large cell lung cancer returns after treatment, understanding what to expect and recognizing the signs can help patients and their families navigate this challenging time with greater confidence and awareness.

  • 1

    Large cell lung cancer stage 0

    Stage 0 large cell lung cancer represents the earliest possible detection of this disease, when abnormal cells are found only in the top lining of the lung and have not yet spread deeper into surrounding tissue.

  • 1

    Large cell lung cancer stage III

    Large cell lung cancer stage III is a locally advanced form of cancer where the disease has begun to spread beyond the lungs to nearby tissues and lymph nodes, but has not yet reached distant parts of the body. Understanding this stage and the available treatment options is essential for patients facing this diagnosis.

  • 1

    Large cell lung cancer stage IV

    Stage IV large cell lung cancer represents the most advanced form of this rare type of lung cancer, where the disease has spread beyond the lungs to other parts of the body. While this diagnosis presents significant challenges, modern treatments are helping patients live longer and better quality lives.

  • 1

    Laryngeal cancer

    Laryngeal cancer is a disease where cancer cells grow uncontrollably in the larynx, the voice box in your throat that helps you speak, breathe, and swallow. While symptoms like hoarseness can be easy to mistake for a common cold, understanding the signs and treatment options is crucial for early detection and better outcomes.

  • 1

    Laryngeal cancer stage I

    Stage I laryngeal cancer is the earliest form of cancer affecting the voice box, where the tumor is limited to a small area and has not spread to lymph nodes or distant sites in the body.

  • 1

    Laryngeal cancer stage II

    Stage II laryngeal cancer is an early form of cancer affecting the voice box that has grown beyond the initial area where it started but remains within the larynx and has not spread to lymph nodes or other organs.

  • 1

    Laryngeal cancer stage III

    Stage III laryngeal cancer is a serious condition where cancer has spread beyond the voice box to nearby tissues or lymph nodes, but has not yet reached distant parts of the body. Understanding this stage and the available treatment options can help patients make informed decisions about their care.

  • 1

    Laryngeal leukoplakia

    Laryngeal leukoplakia appears as white patches on the vocal folds and can range from harmless to precancerous or even cancerous. Understanding this condition is crucial because early detection and proper treatment can prevent serious complications.

  • 6

    Laryngeal squamous cell carcinoma

    Laryngeal squamous cell carcinoma is the most common type of cancer affecting the voice box, accounting for the vast majority of laryngeal cancers. This disease develops when thin, flat cells lining the inside of the larynx begin to grow uncontrollably, potentially affecting your ability to speak, breathe, and swallow.

  • 1

    Latent autoimmune diabetes in adults

    Latent autoimmune diabetes in adults (LADA) is a form of diabetes that shares features of both Type 1 and Type 2 diabetes, affecting adults over 30 years old. Often called Type 1.5 diabetes, it develops slowly over months to years and is frequently misdiagnosed as Type 2 diabetes, potentially leading to inappropriate treatment and complications.

  • 1

    Latent tuberculosis

    Latent tuberculosis means you carry tuberculosis bacteria in your body, but they are inactive and cannot make you sick or spread to others. However, without treatment, these sleeping bacteria can wake up and cause active disease.

  • 0

    Leber’s congenital amaurosis

    Leber’s congenital amaurosis is a rare inherited eye disease that causes severe vision loss or blindness in babies and young children. It affects the retina, the light-sensitive tissue at the back of the eye, and is one of the most common causes of inherited blindness in childhood.

  • 2

    Left ventricular dysfunction

    Left ventricular dysfunction occurs when the heart’s main pumping chamber loses its ability to effectively send oxygen-rich blood throughout the body, leading to symptoms that can significantly impact daily life and overall health.

  • 3

    Left ventricular failure

    Left ventricular failure happens when the heart’s main pumping chamber can’t deliver enough blood to the body’s vital organs, causing symptoms that can significantly affect daily life and require ongoing medical care.

  • 3

    Leiomyosarcoma

    Leiomyosarcoma is a rare and aggressive cancer that develops in smooth muscles found in various organs throughout the body. While it can grow quickly and spread to other tissues, early detection and treatment offer the possibility of recovery.

  • 3

    Leiomyosarcoma metastatic

    Metastatic leiomyosarcoma is an aggressive cancer that has spread from its original site to other parts of the body. While this advanced stage presents serious challenges, understanding the disease, treatment options, and survival factors can help patients and their families navigate this difficult journey.

  • 1

    Leiomyosarcoma recurrent

    Recurrent leiomyosarcoma is when this aggressive cancer returns after initial treatment, presenting challenges for patients and their medical teams. Understanding recurrence patterns, treatment options, and factors that influence survival can help patients navigate this difficult journey.

  • 5

    Lennox-Gastaut syndrome

    Lennox-Gastaut syndrome is a severe form of childhood epilepsy that causes multiple types of seizures, developmental delays, and lasting disabilities. While there is no cure, various treatments can help control symptoms and improve quality of life.

  • 3

    Leukaemia

    Leukaemia is a cancer of the blood that starts when abnormal cells multiply rapidly in the bone marrow, crowding out healthy blood cells and affecting the body’s ability to fight infections, carry oxygen, and form blood clots.

  • 1

    Leukocyte adhesion deficiency

    Leukocyte adhesion deficiency is a rare genetic disorder where white blood cells cannot reach infection sites to fight bacteria and other invaders, leading to severe, recurrent infections that often begin in infancy and can be life-threatening.

  • 2

    Leukoencephalopathy

    Leukoencephalopathy refers to disorders affecting the white matter of the brain, the tissue that protects nerve cells and helps them communicate. These conditions can range from rare viral infections in people with weakened immune systems to inherited genetic disorders that progressively damage the brain’s protective coating.

  • 1

    Lichen planopilaris

    Lichen planopilaris is a condition that causes inflammation in the scalp, leading to patches of permanent hair loss through scarring. While the exact cause remains unclear, early treatment is crucial to prevent further damage, as lost hair cannot regrow once the follicles are destroyed.

  • 2

    Lichen planus

    Lichen planus is a skin condition that can cause itchy, flat-topped bumps on your skin and white patches or painful sores inside your mouth. While the exact cause remains unknown, this inflammatory condition affects the skin, mouth, nails, scalp, and genital areas, and often clears up on its own within one to two years.

  • 4

    Lichen sclerosus

    Lichen sclerosus is a long-term skin condition that causes patches of white, itchy skin, most commonly affecting the genital and anal areas. While there’s no cure, treatment can help control symptoms and prevent serious complications like scarring and an increased cancer risk.

  • 1

    Lichenoid keratosis

    Lichenoid keratosis is a small, harmless skin growth that appears as an inflamed spot or thin pigmented patch, usually showing up as a single lesion that may change color from red to purple or brown over time.

  • 1

    Ligament operation

    Surgery to repair damaged ligaments can restore stability and function to injured joints, but the journey from injury to full recovery requires commitment, patience, and proper rehabilitation.

  • 1

    Ligament sprain

    A ligament sprain is one of the most common injuries that can happen to anyone, from athletes to people going about their daily activities. Understanding what happens when a ligament is injured and how to care for it properly can help you recover faster and avoid long-term problems.

  • 0

    Limb reduction defect

    Limb reduction defects occur when a baby is born with a part of or the entire arm or leg missing or not fully formed. This birth defect affects approximately 1 in every 2,100 babies born in the United States, and while the exact causes remain largely unknown, proper treatment and care can help children with these conditions live full and productive lives.

  • 1

    Lip and/or oral cavity cancer

    Lip and oral cavity cancer is a disease that begins in the lips or mouth, and while it affects thousands of Americans each year, many cases can be prevented through lifestyle changes and early detection can significantly improve survival rates.

  • 0

    Lipid metabolism disorder

    When your body cannot properly process fats, harmful amounts can build up, potentially damaging vital organs and increasing your risk of serious health complications.

  • 2

    Lipoprotein metabolism disorder

    Lipoprotein metabolism disorders are conditions where your body cannot properly process fats in the blood, leading to abnormal levels of cholesterol and triglycerides that can increase your risk of heart disease, stroke, and other serious health problems.

  • 3

    Liposarcoma

    Liposarcoma is a rare type of cancer that begins in fat cells and can develop anywhere in the body, though it most commonly appears in the muscles of the limbs or deep within the belly.

  • 2

    Liposarcoma metastatic

    Liposarcoma metastatic is a rare and serious condition where liposarcoma, a cancer that begins in fat cells, spreads from its original location to other parts of the body. Understanding the behavior of different liposarcoma types, their patterns of spread, and available treatment options is crucial for patients facing this challenging diagnosis.

  • 1

    Liposarcoma recurrent

    Recurrent liposarcoma is a challenging condition where the cancer returns after initial treatment, often within the first two years following surgery. Understanding the patterns of recurrence and the importance of close monitoring can help patients and healthcare providers detect and manage this condition more effectively.

  • 3

    Liver disorder

    The liver is your body’s largest internal organ, performing hundreds of vital tasks every day—from filtering toxins to helping digest food. When the liver becomes damaged, it can affect your entire body, but many types of liver damage can be treated, slowed, or even reversed with early action and healthy lifestyle changes.

  • 10

    Liver transplant

    A liver transplant is a life-saving surgery that replaces a diseased or failing liver with a healthy one from a donor. This complex procedure offers patients with end-stage liver disease or acute liver failure the chance for restored health and an extended lifespan.

  • 1

    Liver transplant rejection

    When a new liver is transplanted, the body’s immune system may see it as a foreign threat and try to attack it, a process known as rejection. While modern medicine has significantly reduced rejection rates, understanding this complication remains vital for anyone receiving or caring for someone with a transplanted liver.

  • 1

    Loeys-Dietz syndrome

    Loeys-Dietz syndrome is a genetic condition that affects the body’s connective tissue, causing problems with blood vessels, bones, skin, and other body parts. This disorder can lead to serious complications, especially in the heart and blood vessels, but with proper diagnosis and care, many people with the condition can live full lives.

  • 2

    Low anterior resection syndrome

    Low anterior resection syndrome is a collection of bowel-related symptoms that can significantly affect daily life after rectal cancer surgery. Studies suggest that as many as 60 to 90 percent of people who undergo sphincter-preserving rectal surgery experience these symptoms, which can persist long after recovery from cancer treatment.

  • 0

    Low cardiac output syndrome

    Low cardiac output syndrome is a serious complication that can occur after heart surgery, when the heart temporarily loses its ability to pump enough blood to meet the body’s needs. This condition, most commonly seen in patients recovering from cardiac operations, can lead to significant health problems if not recognized and treated promptly.

  • 0

    Lower limb fracture

    Lower limb fractures are breaks or cracks in the bones of the leg, including the hip, thigh bone, shin bone, calf bone, ankle, and foot. These injuries can happen to anyone through falls, car accidents, or sports activities, and they require immediate medical care to heal properly.

  • 1

    Lumbosacral radiculopathy

    Lumbosacral radiculopathy affects millions of people worldwide, causing pain that radiates from the lower back down through the legs. While it’s a leading cause of disability in younger adults, most cases respond well to treatment without surgery.

  • 4

    Lung adenocarcinoma

    Lung adenocarcinoma is the most common form of lung cancer in the United States, affecting thousands of people each year. While this diagnosis can feel overwhelming, advances in treatment are helping more people live longer and better lives than ever before.

  • 1

    Lung adenocarcinoma stage III

    Stage 3 lung adenocarcinoma is a form of lung cancer that has spread beyond the lung but has not yet reached distant organs. About one-third of people with lung cancer receive their diagnosis at this stage, when the disease is considered locally advanced and requires careful, coordinated treatment involving multiple approaches.

  • 1

    Lung adenocarcinoma stage IV

    Stage IV lung adenocarcinoma represents the most advanced form of this disease, where cancer has spread beyond the lungs to distant parts of the body. While this diagnosis brings significant challenges, advances in treatment options including targeted therapies and immunotherapy continue to improve outcomes for patients.

  • 2

    Lung cancer metastatic

    Metastatic lung cancer occurs when cancer that started in the lungs has spread to other parts of the body. While this advanced stage cannot usually be cured, modern treatments can help control the disease, manage symptoms, and improve quality of life for some time.

  • 1

    Lung carcinoma cell type unspecified recurrent

    Recurrent lung cancer occurs when cancer cells return after successful treatment and a period without detectable signs of disease. Understanding the patterns of recurrence, warning signs, and treatment options can help patients and caregivers navigate this challenging phase of the cancer journey.

  • 3

    Lung disorder

    Lung disorder is a broad term covering health problems that prevent your lungs from working as they should, affecting millions of people worldwide and ranking among the leading causes of death.

  • 25

    Lung neoplasm malignant

    Lung cancer is one of the most common and serious types of cancer, caused by harmful cells in your lungs growing unchecked. While it remains a leading cause of cancer-related deaths, advances in treatments have caused a significant decline in lung cancer deaths in recent years, offering new hope to patients and their families.

  • 1

    Lung squamous cell carcinoma metastatic

    Metastatic squamous cell carcinoma of the lung is an advanced form of cancer that has spread beyond the lungs to other parts of the body, presenting significant challenges for patients and requiring specialized treatment approaches.

  • 0

    Lung squamous cell carcinoma stage III

    Stage 3 squamous cell lung cancer means the disease has spread beyond the lung but has not yet reached distant parts of the body. About one-third of all lung cancer cases are discovered at this stage, which doctors call locally advanced cancer. Treatment usually involves a combination of therapies tailored to each patient’s specific situation.