#1 Clinical Trials Search in Europe

Adrenaline Tartrate Ph. Eur.

This article examines several clinical trials investigating the use of Adrenaline Tartrate Ph. Eur. (also known as epinephrine) in different medical scenarios. These studies aim to evaluate the safety, efficacy, and potential applications of this drug in conditions such as multiple myeloma, cardiac arrest, systemic lupus erythematosus, and chronic inducible urticaria. The trials explore various aspects, including diagnostic imaging, emergency medical interventions, and long-term treatment options.

Table of Contents

What is Adrenaline Tartrate PH. EUR.?

Adrenaline Tartrate PH. EUR., also known as epinephrine, is a medication that belongs to a class of drugs called catecholamines[1]. It is a hormone and neurotransmitter naturally produced by the body’s adrenal glands. As a medication, it is used in various emergency situations and medical conditions due to its powerful effects on the body.

Medical Uses

Adrenaline Tartrate PH. EUR. is used in several medical situations, including:

  • Cardiac arrest: It is a crucial medication used during cardiopulmonary resuscitation (CPR) for patients experiencing cardiac arrest outside the hospital[2].
  • Anaphylaxis: It is the first-line treatment for severe allergic reactions, often administered through auto-injectors like EpiPen[4].
  • Asthma: In some cases, it may be used to treat severe asthma attacks.
  • Shock: Adrenaline can be used to treat various types of shock, including anaphylactic shock.

How is it Administered?

Adrenaline Tartrate PH. EUR. can be administered in several ways, depending on the medical situation:

  • Intramuscular injection: This is the most common method for treating anaphylaxis, often using auto-injectors like EpiPen[4].
  • Intravenous injection: Used in hospital settings, particularly during cardiac arrest situations[2].
  • Intraosseous injection: In some emergency situations, particularly in children or when intravenous access is difficult, adrenaline may be injected directly into the bone marrow[2].

Current Clinical Trials

Adrenaline Tartrate PH. EUR. is being studied in various clinical trials to optimize its use and explore potential new applications:

  • A study is comparing intravenous versus intraosseous vascular access for administering adrenaline during out-of-hospital cardiac arrest[2]. This research aims to determine if there’s a difference in the return of spontaneous circulation depending on the method of administration.
  • Adrenaline is also being used as a rescue medication in clinical trials for other conditions, such as chronic inducible urticaria (a type of chronic hives)[4].

Potential Side Effects

While adrenaline is a life-saving medication, it can cause some side effects, especially when used in high doses or frequently. These may include:

  • Rapid heartbeat or palpitations
  • Anxiety or nervousness
  • Tremors
  • Headache
  • Nausea
  • Pale skin

In clinical trials, researchers closely monitor for these and other potential adverse events to ensure patient safety[2][4].

Precautions and Contraindications

While adrenaline is crucial in many emergency situations, there are some precautions to consider:

  • Patients with certain heart conditions may be at increased risk of side effects.
  • It should be used with caution in patients with high blood pressure, diabetes, or thyroid disorders.
  • Interactions with certain medications, such as beta-blockers, may occur.

Always inform your healthcare provider about all medications you’re taking and any existing health conditions before using adrenaline[4].

Study Focus Patient Population Primary Objectives Key Endpoints
Multiple Myeloma Imaging Adults under 66 with multiple myeloma Evaluate [68Ga]Ga-PentixaFor-PET sensitivity Detection of myeloma lesions, comparison with FDG-PET
Cardiac Arrest Treatment Out-of-hospital cardiac arrest patients Compare IV vs IO vascular access Return of spontaneous circulation, 30-day survival
Systemic Lupus Erythematosus Patients with moderate to severe SLE Assess dapirolizumab pegol efficacy and safety BICLA response, prevention of disease flares
Chronic Inducible Urticaria Adults with CIndU unresponsive to antihistamines Evaluate briquilimab safety and efficacy Adverse events, provocation testing results

FAQ

  • What is Adrenaline Tartrate Ph. Eur. used for in these clinical trials? Adrenaline Tartrate Ph. Eur. is being studied for various purposes in these trials, including as an emergency medication for cardiac arrest, as a potential treatment for systemic lupus erythematosus, and as a rescue medication for severe allergic reactions in patients with chronic inducible urticaria.
  • Are there any specific patient groups being targeted in these studies? Yes, the trials focus on different patient groups, including adults with multiple myeloma, patients experiencing out-of-hospital cardiac arrest, individuals with systemic lupus erythematosus, and adults with chronic inducible urticaria who are unresponsive to antihistamines.
  • What are some of the main objectives of these clinical trials? The main objectives vary by study but include evaluating the safety and efficacy of Adrenaline Tartrate Ph. Eur., assessing its role in emergency situations, exploring its long-term effects in chronic conditions, and investigating its use in combination with other treatments.
  • How is the safety of Adrenaline Tartrate Ph. Eur. being monitored in these trials? Safety is being monitored through various methods, including tracking adverse events, conducting regular laboratory assessments, performing electrocardiograms (ECGs), and monitoring vital signs. Some trials also have specific safety endpoints to assess tolerability and immunogenicity.
  • What are some potential benefits of participating in these clinical trials? Potential benefits include access to new treatments or combinations of treatments, close medical monitoring, and the opportunity to contribute to medical research. However, it's important to note that participation also carries risks, and not all participants may experience direct benefits.

Ongoing Clinical Trials on Adrenaline Tartrate Ph. Eur.

  • Study on Briquilimab for Adults with Chronic Inducible Urticaria Unresponsive to H1-Antihistamines

    Not recruiting

    1 1 1 1
    Investigated diseases:
    Investigated drugs:
    Germany

  • Study on Epinephrine and Amiodarone for Patients with Cardiac Arrest Outside the Hospital

    Not recruiting

    2 1 1 1
    Investigated drugs:
    Denmark

  • Study on [68Ga]Ga-PentixaFor for Detecting Multiple Myeloma in Patients Under 66 Eligible for Stem Cell Transplantation

    Not recruiting

    2 1 1 1
    Investigated diseases:
    Investigated drugs:
    France

Glossary

  • Adrenaline Tartrate Ph. Eur.: A form of epinephrine, which is a hormone and medication used to treat various conditions, including anaphylaxis, cardiac arrest, and asthma. It works by stimulating the heart, constricting blood vessels, and opening airways in the lungs.
  • Multiple Myeloma: A type of blood cancer that affects plasma cells, which are a type of white blood cell that produces antibodies to help fight infections.
  • Systemic Lupus Erythematosus (SLE): A chronic autoimmune disease that can affect various parts of the body, including skin, joints, kidneys, brain, and other organs.
  • Chronic Inducible Urticaria (CIndU): A form of chronic hives triggered by specific stimuli such as cold, heat, pressure, or friction on the skin.
  • Out-of-hospital Cardiac Arrest (OHCA): A sudden loss of heart function that occurs outside of a hospital setting, often leading to loss of consciousness and breathing.
  • PET-CT: A combination of Positron Emission Tomography (PET) and Computed Tomography (CT) scans used to produce detailed, computer-generated pictures of organs and tissues inside the body.
  • Intravenous (IV): Administered directly into a vein.
  • Intraosseous (IO): Administered directly into the bone marrow.
  • Adverse Event (AE): Any unfavorable and unintended sign, symptom, or disease temporarily associated with the use of a medical treatment or procedure.
  • Pharmacokinetics (PK): The study of how a drug is absorbed, distributed, metabolized, and eliminated by the body.
  • Pharmacodynamics (PD): The study of the biochemical and physiological effects of drugs on the body.
  • BILAG: British Isles Lupus Assessment Group index, a system used to measure disease activity in patients with lupus.
  • SLEDAI-2K: Systemic Lupus Erythematosus Disease Activity Index 2000, a tool used to assess disease activity in lupus patients.
  • Standard of Care (SOC): The typical treatment or care given to patients with a specific condition, based on current medical knowledge and practices.

References

  1. http://clinicaltrials.eu/trial/study-on-68gaga-pentixafor-for-detecting-multiple-myeloma-in-patients-under-66-eligible-for-stem-cell-transplantation/
  2. http://clinicaltrials.eu/trial/study-on-epinephrine-and-amiodarone-for-patients-with-cardiac-arrest-outside-the-hospital/
  3. http://clinicaltrials.eu/trial/study-on-the-long-term-safety-of-dapirolizumab-pegol-for-patients-with-systemic-lupus-erythematosus/
  4. http://clinicaltrials.eu/trial/study-on-briquilimab-for-adults-with-chronic-inducible-urticaria-unresponsive-to-h1-antihistamines/
  5. http://clinicaltrials.eu/trial/study-on-the-effectiveness-and-safety-of-dapirolizumab-pegol-for-patients-with-moderate-to-severe-systemic-lupus-erythematosus/