Explore popular diseases in clinical trials

Check which popular diseases are currently being frequently studied.

See also our rare diseases glossary and drug database.

Starting by letter

To open the diseases glossary, select a letter from the list below.

Most popular diseases

The list below features the most popular diseases currently involved in ongoing clinical trials.

Disease trials
Non-small cell lung cancer 228
Breast cancer 94
Obesity 86
Prostate cancer 73
Colorectal cancer 69
Ovarian cancer 66
Non-small cell lung cancer metastatic 66
Crohn’s disease 61
Type 2 diabetes mellitus 54
Rheumatoid arthritis 54
Triple negative breast cancer 52
Hormone receptor positive HER2 negative breast cancer 52
Asthma 51
Acute myeloid leukaemia 50
Squamous cell carcinoma of head and neck 50
Chronic kidney disease 49
Neoplasm 48
Colorectal cancer metastatic 47
Hepatocellular carcinoma 47
Systemic lupus erythematosus 40
Colitis ulcerative 40
Multiple sclerosis 39
Overweight 39
Dementia Alzheimer’s type 39
Gastric cancer 38
Myelodysplastic syndrome 37
Parkinson’s disease 37
HER2 positive breast cancer 37
Glioblastoma 37
Atrial fibrillation 34
Bladder cancer 34
Chronic obstructive pulmonary disease 33
Ischaemic stroke 33
Prostate cancer metastatic 33
Myasthenia gravis 32
Renal transplant 31
Type 1 diabetes mellitus 31
Head and neck cancer 31
Endometrial cancer 31
Malignant melanoma 31
Non-small cell lung cancer stage IV 31
Diffuse large B-cell lymphoma 31
Breast cancer metastatic 31
HIV infection 30
Dermatitis atopic 28
Cholangiocarcinoma 28
Coronary artery disease 28
Plasma cell myeloma 28
Pulmonary arterial hypertension 28
Neoplasm malignant 27
Rectal cancer 27
Renal cell carcinoma 26
Pancreatic carcinoma 26
Schizophrenia 26
Duchenne muscular dystrophy 25
Non-small cell lung cancer stage III 25
Follicular lymphoma 25
COVID-19 25
Migraine 24
Hormone receptor positive breast cancer 24
Idiopathic pulmonary fibrosis 24
Non-small cell lung cancer stage IIIB 24
Sepsis 24
Chronic lymphocytic leukaemia 24
Soft tissue sarcoma 24
Mantle cell lymphoma 23
Small cell lung cancer extensive stage 23
Colon cancer 23
Fallopian tube cancer 23
Influenza 22
Small cell lung cancer 21
Interstitial lung disease 21
Acute myocardial infarction 21
Oesophageal adenocarcinoma 21
Amyotrophic lateral sclerosis 21
Chronic rhinosinusitis with nasal polyps 20
Cystic fibrosis 20
Glioma 20
Myelofibrosis 19
Neuroblastoma 19
B-cell lymphoma 19
Sickle cell disease 19
Major depression 19
Procedural pain 19
Axial spondyloarthritis 18
Osteoarthritis 18
Breast cancer female 17
Critical illness 17
Acute kidney injury 17
Hereditary angioedema 17
Relapsing-remitting multiple sclerosis 16
Acute coronary syndrome 16
IgA nephropathy 16
Psoriasis 16
Gastrooesophageal cancer 16
Ewing’s sarcoma 16
Cardiac failure 16
Vitiligo 16
Transitional cell carcinoma 15
Giant cell arteritis 15

Diseases starting with t

  • 1

    Traumatic pain

    Traumatic pain is physical pain that persists after a traumatic injury, often continuing long after the body’s initial wounds have healed and sometimes lasting for months or even years.

  • 0

    Tricuspid valve disease

    Tricuspid valve disease affects the valve between the two right heart chambers, preventing it from working properly. While it can remain silent for years, moderate to severe cases can damage the heart over time and require treatment ranging from medications to minimally invasive procedures.

  • 2

    Trigeminal neuralgia

    Trigeminal neuralgia causes sudden, severe facial pain that feels like an electric shock, often triggered by everyday activities like brushing teeth or touching the face. This chronic pain condition can be life-altering, but various treatments are available to help manage symptoms and restore quality of life.

  • 51

    Triple negative breast cancer

    Triple negative breast cancer is an aggressive form of breast cancer that doesn’t respond to the same treatments as other types. Understanding what makes this cancer different can help you make informed decisions about your care and feel more in control during your journey.

  • 1

    Triple positive breast cancer

    Triple positive breast cancer is a unique form of breast cancer where cancer cells respond to three specific factors: estrogen, progesterone, and a protein called HER2. While this diagnosis once meant facing an aggressive cancer with limited options, today’s treatments have transformed the outlook, offering multiple effective ways to fight the disease.

  • 5

    Trisomy 21

    Trisomy 21, commonly known as Down syndrome, is the most common chromosomal condition in humans, affecting about 1 in every 700 babies born in the United States—approximately 5,000 to 6,000 babies each year.

  • 2

    Tuberculosis

    Tuberculosis is a serious bacterial infection that most often affects the lungs, but it can be treated successfully with antibiotics if diagnosed and treated properly.

  • 7

    Tuberous sclerosis complex

    Tuberous sclerosis complex is a rare genetic disease that causes non-cancerous tumors to develop in multiple organs throughout the body, particularly in the brain, kidneys, heart, skin, and lungs. While some people live with few symptoms, others may experience seizures, developmental delays, and serious organ complications that require lifelong monitoring and care.

  • 1

    Tubulointerstitial nephritis

    Tubulointerstitial nephritis is inflammation that affects specific parts of the kidneys—the small tubes and surrounding tissue—but typically spares the tiny blood vessels that filter waste. This condition can develop suddenly or gradually, and while some people experience noticeable symptoms, others may have none at all.

  • 1

    Tumour of ampulla of Vater

    Tumour of the ampulla of Vater is a rare cancer that develops in a small but crucial opening where bile and digestive juices from your liver and pancreas meet before emptying into your small intestine. Although rare, affecting less than 1% of digestive system cancers, early detection can make a significant difference in treatment outcomes.

  • 1

    Tumour thrombosis

    Tumour thrombosis is a serious complication that occurs when cancer cells grow directly into blood vessels, forming a blockage made of tumour tissue rather than a typical blood clot.

  • 5

    Turner’s syndrome

    Turner’s syndrome is a genetic condition that affects only females, occurring when one of the X chromosomes is partially or completely missing. While there is no cure, early diagnosis and treatment can help girls and women with this condition lead healthy, productive lives.

  • 0

    Tympanic membrane hyperaemia

    Tympanic membrane hyperaemia refers to increased blood flow and redness in the thin layer of tissue that separates the outer ear from the middle ear, known as the eardrum. This condition is often an early sign of ear problems and can occur alongside various ear infections and inflammatory conditions.

  • 1

    Tympanic membrane perforation

    A tear or hole in the eardrum can happen from an infection, injury, or sudden pressure change, often causing pain, drainage, or hearing loss—but most perforations heal on their own within weeks.

  • 32

    Type 1 diabetes mellitus

    Type 1 diabetes is a lifelong condition where your body cannot produce insulin, a vital hormone that controls blood sugar levels. While it often begins in childhood, it can develop at any age and requires daily management with insulin therapy.

  • 55

    Type 2 diabetes mellitus

    Type 2 diabetes is a chronic condition where your body struggles to use insulin properly, causing blood sugar levels to rise. While it was once called “adult-onset diabetes,” it now affects people of all ages, including children, making it one of the most common health challenges worldwide.

  • 1

    Type IIa hyperlipidaemia

    Type IIa hyperlipidaemia is a genetic condition that causes dangerously high levels of cholesterol in the blood from birth, significantly increasing the risk of heart disease and stroke at a young age.

  • 0

    Type V hyperlipidaemia

    Type V hyperlipidaemia is a severe form of fat disorder in the blood that combines very high levels of triglycerides with the presence of multiple types of lipid particles, putting people at risk for serious complications like pancreatitis and heart disease.