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SODIUM HYDROXIDE

Clinical trials involving SODIUM HYDROXIDE are listed here as part of study medicines used in specific research settings. These trials look at safety, body changes, and other effects in target groups such as women with Turner syndrome and people on hemodialysis.

Table of contents

Clinical trials overview

The provided data include two interventional studies, which means researchers give a treatment and then measure the results.[1][2]

Both studies are authorised, and both include SODIUM HYDROXIDE as part of the study intervention.[1][2]

One study is in Phase 2 and the other is in Phase 3, so the research is already testing effects in people rather than only in early lab work.[1][2]

Turner syndrome study

The first trial is titled Testosterone Replacement Therapy in Women with Turner Syndrome and includes women with Turner syndrome.[1]

This is a Phase 2 study with an enrollment of 50 participants.[1]

The brief summary says the study aims to evaluate the endocrine, physiological, cardiovascular, neurocognitive, and genomic effects of transdermal TRT as a supplement to ERT in women with TS.[1]

In simple words, the study is checking how this treatment may affect hormones, body function, heart and blood vessel health, thinking skills, and genes in this patient group.[1]

The intervention list includes SODIUM HYDROXIDE together with other ingredients in a transdermal product, which means it is applied through the skin.[1]

Hemodialysis study

The second trial is titled LOTUS and includes patients with muscle protein turnover issues who are on hemodialysis.[2]

This is a Phase 3 study with an enrollment of 20 participants.[2]

The brief summary says the study is designed to look at the effect of IDPN on muscle protein synthesis in chronic hemodialysis patients and to characterize the hemodynamic effects of IDPN.[2]

The primary outcome is the difference in myofibrillar fractional synthetic rate during one week of treatment with IDPN versus control.[2]

This means the researchers want to see whether treatment changes the speed at which muscle protein is made, compared with a control group.[2]

In this trial data, SODIUM HYDROXIDE appears within a combination intervention used in the study setting.[2]

Outcomes and measures

In the Turner syndrome study, the main outcome is body composition, measured by total body DXA-scan.[1]

The DXA scan looks at bone mass, visceral fat, subcutaneous fat, lean muscle mass, abdominal circumference, and weight.[1]

In the hemodialysis study, the main outcome is the myofibrillar fractional synthetic rate, which is a measure of muscle protein building.[2]

The study also looks at hemodynamic effects, meaning effects on circulation and blood flow.[2]

What patients should know

These trials are focused on specific groups, so not everyone would be eligible.[1][2]

One study is for women with Turner syndrome, while the other is for chronic hemodialysis patients with muscle protein turnover concerns.[1][2]

The data do not describe SODIUM HYDROXIDE as a stand-alone treatment goal; instead, it appears as part of a larger study product or combination.[1][2]

Because the trials measure specific outcomes, they are designed to answer research questions about how the interventions affect the body in these patient groups.[1][2]

Trial IDPhaseCondition studiedStatusEnrollment
2024-517755-12-00Phase 2Turner SyndromeAuthorised50
2025-522111-42-02Phase 3muscle protein turnover; hemodialysisAuthorised20

FAQ

  • What are clinical trials with SODIUM HYDROXIDE studying? They are studying treatment effects in specific trial settings, including body composition changes in women with Turner syndrome and muscle protein synthesis in people on hemodialysis.
  • Who can take part in these trials? The target groups in the data are women with Turner syndrome and chronic hemodialysis patients. Each trial has its own entry rules.
  • What phases are these trials? The trials shown are Phase 2 and Phase 3 studies. This means they are testing effects in people and measuring specific outcomes.
  • What outcomes are being measured? One trial measures body composition, such as bone mass, fat mass, muscle mass, waist size, and weight. Another measures muscle protein synthesis and hemodynamic effects, which are changes in blood flow and circulation.
  • Are these studies about SODIUM HYDROXIDE alone? No. In the trial data, SODIUM HYDROXIDE appears as one part of a transdermal treatment or a combination product used in the study.

Ongoing Clinical Trials on SODIUM HYDROXIDE

  • Study on Testosterone and Isopropyl Myristate for Women with Turner Syndrome

    Recruiting

    2 1 1
    Investigated diseases:
    Investigated drugs:
    Denmark

  • Study of Intradialytic Parenteral Nutrition for Muscle Protein Production in Patients on Long-term Hemodialysis Treatment

    Not yet recruiting

    3 1 1 1
    Investigated diseases:
    Investigated drugs:
    The Netherlands

Glossary

  • Turner syndrome: A genetic condition that affects females and can influence growth and development.
  • Hemodialysis: A treatment that filters the blood when the kidneys do not work well enough.
  • Phase 2: A trial stage that looks at how well a treatment works and continues to watch safety.
  • Phase 3: A later trial stage with more participants, used to confirm effects and collect more safety information.
  • Interventional study: A study in which researchers give a treatment or intervention and then measure the results.
  • Body composition: The amounts of bone, fat, and muscle in the body.
  • Dual-energy x-ray absorptiometry (DXA): A scan that measures bone and body tissue, including fat and lean mass.
  • Myofibrillar fractional synthetic rate: A measure of how fast muscle protein is being made.
  • Hemodynamic effects: Effects on blood flow and circulation.
  • Transdermal use: Given through the skin, usually with a gel or similar product.

References

  1. https://clinicaltrials.gov/study/2024-517755-12-00
  2. https://clinicaltrials.gov/study/2025-522111-42-02