Explore popular diseases in clinical trials

Check which popular diseases are currently being frequently studied.

See also our rare diseases glossary and drug database.

Starting by letter

To open the diseases glossary, select a letter from the list below.

Most popular diseases

The list below features the most popular diseases currently involved in ongoing clinical trials.

Disease trials
Non-small cell lung cancer 228
Breast cancer 94
Obesity 86
Prostate cancer 73
Colorectal cancer 69
Ovarian cancer 66
Non-small cell lung cancer metastatic 66
Crohn’s disease 61
Type 2 diabetes mellitus 54
Rheumatoid arthritis 54
Triple negative breast cancer 52
Hormone receptor positive HER2 negative breast cancer 52
Asthma 51
Acute myeloid leukaemia 50
Squamous cell carcinoma of head and neck 50
Chronic kidney disease 49
Neoplasm 48
Colorectal cancer metastatic 47
Hepatocellular carcinoma 47
Systemic lupus erythematosus 40
Colitis ulcerative 40
Multiple sclerosis 39
Overweight 39
Dementia Alzheimer’s type 39
Gastric cancer 38
Myelodysplastic syndrome 37
Parkinson’s disease 37
HER2 positive breast cancer 37
Glioblastoma 37
Atrial fibrillation 34
Bladder cancer 34
Chronic obstructive pulmonary disease 33
Ischaemic stroke 33
Prostate cancer metastatic 33
Myasthenia gravis 32
Renal transplant 31
Type 1 diabetes mellitus 31
Head and neck cancer 31
Endometrial cancer 31
Malignant melanoma 31
Non-small cell lung cancer stage IV 31
Diffuse large B-cell lymphoma 31
Breast cancer metastatic 31
HIV infection 30
Dermatitis atopic 28
Cholangiocarcinoma 28
Coronary artery disease 28
Plasma cell myeloma 28
Pulmonary arterial hypertension 28
Neoplasm malignant 27
Rectal cancer 27
Renal cell carcinoma 26
Pancreatic carcinoma 26
Schizophrenia 26
Duchenne muscular dystrophy 25
Non-small cell lung cancer stage III 25
Follicular lymphoma 25
COVID-19 25
Migraine 24
Hormone receptor positive breast cancer 24
Idiopathic pulmonary fibrosis 24
Non-small cell lung cancer stage IIIB 24
Sepsis 24
Chronic lymphocytic leukaemia 24
Soft tissue sarcoma 24
Mantle cell lymphoma 23
Small cell lung cancer extensive stage 23
Colon cancer 23
Fallopian tube cancer 23
Influenza 22
Small cell lung cancer 21
Interstitial lung disease 21
Acute myocardial infarction 21
Oesophageal adenocarcinoma 21
Amyotrophic lateral sclerosis 21
Chronic rhinosinusitis with nasal polyps 20
Cystic fibrosis 20
Glioma 20
Myelofibrosis 19
Neuroblastoma 19
B-cell lymphoma 19
Sickle cell disease 19
Major depression 19
Procedural pain 19
Axial spondyloarthritis 18
Osteoarthritis 18
Breast cancer female 17
Critical illness 17
Acute kidney injury 17
Hereditary angioedema 17
Relapsing-remitting multiple sclerosis 16
Acute coronary syndrome 16
IgA nephropathy 16
Psoriasis 16
Gastrooesophageal cancer 16
Ewing’s sarcoma 16
Cardiac failure 16
Vitiligo 16
Transitional cell carcinoma 15
Giant cell arteritis 15

Diseases starting with d

  • 5

    Deafness

    Deafness is the complete loss of hearing that affects millions of people worldwide. While most hearing loss is permanent and cannot be reversed, understanding its causes, recognizing its signs, and exploring available treatments can significantly improve quality of life and communication abilities.

  • 0

    Deafness bilateral

    When hearing loss affects both ears, it creates unique challenges in daily life—from following conversations in noisy environments to safely navigating the world around you. Understanding this condition and exploring treatment options can help restore connection and improve quality of life.

  • 2

    Deafness neurosensory

    Sensorineural hearing loss occurs when the delicate structures of the inner ear or the nerve pathways that carry sound to the brain are damaged, affecting your ability to hear soft sounds and making even loud sounds seem muffled or unclear.

  • 1

    Deafness traumatic

    Hearing loss caused by trauma can happen suddenly or develop over time, affecting people’s ability to hear, communicate, and connect with others. Understanding the different types of traumatic hearing loss and their impacts can help individuals seek appropriate care and support.

  • 1

    Death neonatal

    When a baby dies within the first 28 days of life, families face one of the most difficult experiences imaginable. Understanding what neonatal death means, its causes, and the support available can help families navigate this profound loss.

  • 1

    Decreased appetite

    Decreased appetite is when you don’t feel hungry or lose the desire to eat, and it can happen suddenly or develop gradually over time. This common symptom can stem from physical changes, emotional factors, underlying health conditions, or medication side effects.

  • 4

    Dedifferentiated liposarcoma

    Dedifferentiated liposarcoma is a rare and fast-growing cancer that develops from well-differentiated liposarcoma, most commonly affecting adults over 50 and requiring specialized treatment and long-term monitoring.

  • 3

    Deep vein thrombosis

    Deep vein thrombosis is a serious condition where a blood clot forms in a deep vein, most commonly in the leg. While it can cause pain and swelling, sometimes there are no symptoms at all. The real danger lies in the clot breaking free and traveling to the lungs, which can be life-threatening.

  • 1

    Deep vein thrombosis postoperative

    Surgery increases your risk of developing dangerous blood clots in your veins, a condition that requires immediate attention and careful prevention to protect your health and recovery.

  • 2

    Delayed graft function

    Delayed graft function is a common complication after kidney transplantation where the newly transplanted kidney does not start working immediately, often requiring dialysis treatment in the first week after surgery.

  • 4

    Delirium

    Delirium is a serious and sudden change in mental abilities that can develop within hours or days, causing confusion, disorientation, and changes in behavior. While it is more common in older adults, especially those in hospitals, it can affect anyone at any age and requires immediate medical attention.

  • 8

    Dementia

    Dementia is not a single disease, but rather a group of symptoms affecting memory, thinking, and the ability to perform daily activities that worsens over time.

  • 37

    Dementia Alzheimer’s type

    Alzheimer’s disease is the most common cause of dementia, accounting for 60-80% of all dementia cases. This progressive brain condition gradually damages memory, thinking, and the ability to perform everyday tasks, affecting millions of older adults worldwide.

  • 1

    Dementia of the Alzheimer’s type uncomplicated

    Alzheimer’s disease is the most common form of dementia, a condition that slowly destroys memory and thinking skills. While there is no cure, treatments exist to help manage symptoms and slow the disease’s progression, offering hope for improving quality of life for millions of people affected worldwide.

  • 1

    Dementia of the Alzheimer’s type with delusions

    People with Alzheimer’s disease may experience delusions—false beliefs that feel completely real to them—along with suspicion and paranoia. These symptoms can be frightening and distressing for both the person living with the disease and their caregivers, often creating difficult challenges in daily life.

  • 6

    Dementia with Lewy bodies

    Dementia with Lewy bodies is a complex brain disorder caused by abnormal protein deposits that affects thinking, movement, behavior, and sleep. It is one of the most common types of dementia, yet many people have never heard of it.

  • 1

    Demyelination

    Demyelination occurs when the protective covering around your nerve cells becomes damaged, disrupting the way your nerves send messages throughout your body and potentially affecting movement, vision, sensation, and other vital functions.

  • 1

    Dengue fever

    Dengue fever is a mosquito-borne viral illness that affects millions of people each year worldwide, causing symptoms ranging from mild flu-like fever to life-threatening complications that require immediate medical attention.

  • 1

    Dent’s disease

    Dent’s disease is a rare genetic kidney disorder that primarily affects males, causing proteins and calcium to leak into the urine, leading to kidney stones and, in many cases, progressive kidney damage that can result in kidney failure in adulthood.

  • 15

    Depression

    Depression is a common mental health condition that affects millions of people worldwide, causing persistent sadness and changes in how you think, sleep, eat, and function in daily life. While it’s more than just feeling down, effective treatments are available that can help people recover and return to normal activities.

  • 1

    Dermatitis

    Dermatitis is a common condition that causes inflammation, redness, and itching of the skin, affecting millions of people worldwide and ranging from mild discomfort to significant disruption of daily life.

  • 28

    Dermatitis atopic

    Atopic dermatitis is a long-lasting skin condition that causes dry, itchy, and inflamed skin. While it most commonly begins in childhood, it can affect people at any age and requires ongoing care to manage symptoms and prevent flare-ups.

  • 11

    Dermatomyositis

    Dermatomyositis is a rare condition that causes muscle weakness and distinctive skin rashes. While there is no cure, treatment can help improve muscle strength and clear the skin changes, allowing many people to manage their symptoms and maintain their quality of life.

  • 2

    Desmoid tumour

    Desmoid tumours are rare, noncancerous growths that develop in connective tissue throughout the body. Although they don’t spread like cancer, they can grow aggressively into nearby structures, causing pain and serious health problems.

  • 1

    Desmoplastic melanoma

    Desmoplastic melanoma is a rare and unusual form of skin cancer that often looks like a scar rather than a typical mole or dark spot. It accounts for less than 4% of all melanomas and tends to appear on sun-damaged skin of older adults, particularly on the head and neck.

  • 4

    Desmoplastic small round cell tumour

    Desmoplastic small round cell tumour is a very rare and aggressive type of cancer that typically develops in the abdomen and pelvis, most often affecting young males between the ages of 10 and 30.

  • 0

    Developmental hip dysplasia

    Developmental dysplasia of the hip is a condition where the hip joint does not form properly in babies and young children, causing the ball of the hip to fit poorly in its socket or even slip out of place completely.

  • 1

    Device related infection

    Over half of the nearly 2 million healthcare-associated infections can be traced back to implanted medical devices—a growing concern as more people rely on these life-saving technologies to manage serious health conditions.

  • 1

    Diabetes insipidus

    Diabetes insipidus is a rare condition that makes your body lose its ability to balance water properly. While most people make 1 to 3 quarts of urine a day, people with this condition can make up to 20 quarts, leading to constant thirst and frequent trips to the bathroom day and night.

  • 11

    Diabetes mellitus

    Diabetes mellitus is a condition that affects how your body manages blood sugar, impacting millions of people of all ages worldwide. While it cannot be cured, it can be effectively managed through a combination of lifestyle changes, medications, and regular monitoring to help you live a healthy, fulfilling life.

  • 1

    Diabetic autonomic neuropathy

    Diabetic autonomic neuropathy is a serious complication of diabetes that affects the nerves controlling automatic body functions. It can impact your heart rate, blood pressure, digestion, bladder, sexual function, and more. Understanding this condition is essential for managing symptoms and maintaining quality of life.

  • 6

    Diabetic foot

    Diabetic foot problems are a serious complication that can develop when high blood sugar levels damage the nerves and blood vessels in your feet. While these complications can be severe, including the risk of amputation, most can be prevented through careful daily foot care and good diabetes management.

  • 2

    Diabetic foot infection

    Diabetic foot infection is one of the most common and serious complications of diabetes, and the most frequent cause of hospitalization and nontraumatic amputation in people with diabetes. Early diagnosis and proper treatment are essential to prevent severe complications.

  • 2

    Diabetic gastroparesis

    When diabetes affects the stomach’s ability to empty properly, food can sit too long, causing uncomfortable symptoms and making blood sugar control even more challenging.

  • 1

    Diabetic ketoacidosis

    Diabetic ketoacidosis is a serious and life-threatening emergency that can happen when your body doesn’t have enough insulin to use blood sugar for energy. Instead, your body breaks down fat too quickly, creating harmful acids called ketones that build up in your blood and make it too acidic.

  • 5

    Diabetic nephropathy

    Diabetic nephropathy is a serious kidney disease caused by diabetes that affects millions of people worldwide. It develops slowly over many years and can eventually lead to kidney failure if not properly managed. Understanding this condition and taking early action can help protect your kidneys and improve your overall health.

  • 4

    Diabetic neuropathy

    Diabetic neuropathy is nerve damage caused by diabetes that can affect up to half of all people living with the condition, causing pain, numbness, and other serious complications throughout the body.

  • 2

    Diabetic retinal oedema

    Diabetic retinal oedema is a serious eye condition that can affect people with diabetes, where fluid builds up in the macula at the center of the retina, potentially leading to vision loss. With early detection and proper treatment, progression can be slowed or even reversed.

  • 3

    Diabetic retinopathy

    Diabetic retinopathy is a serious eye complication of diabetes that affects blood vessels in the retina and stands as a leading cause of blindness in working-age adults, yet early detection and proper management can significantly protect your vision.

  • 1

    Diarrhoea

    Diarrhoea is one of the most common health problems affecting people of all ages worldwide. While usually mild and temporary, lasting only a few days, it can sometimes signal a more serious condition requiring medical attention. Understanding its causes, recognizing warning signs, and knowing how to manage symptoms can help prevent complications like dehydration.

  • 30

    Diffuse large B-cell lymphoma

    Diffuse large B-cell lymphoma is the most common type of non-Hodgkin lymphoma, affecting thousands of people each year. Although it grows quickly, this aggressive blood cancer often responds well to treatment, and many people can be cured, especially when diagnosed and treated early.

  • 5

    Diffuse large B-cell lymphoma recurrent

    When diffuse large B-cell lymphoma returns after treatment, it presents new challenges—but also new treatment options. Understanding relapse, recognizing the signs, and knowing what therapies are available can make a significant difference in managing this aggressive blood cancer.

  • 5

    Diffuse large B-cell lymphoma refractory

    When diffuse large B-cell lymphoma stops responding to treatment or comes back after a period of improvement, patients face a challenging situation that requires specialized care and newer treatment approaches.

  • 1

    Diffuse large B-cell lymphoma stage I

    Diffuse large B-cell lymphoma (DLBCL) stage I is a fast-growing but often curable blood cancer that affects only one group of lymph nodes in a single area of the body. Although aggressive, early-stage DLBCL responds well to treatment, with many people achieving complete remission.

  • 1

    Diffuse large B-cell lymphoma stage II

    Diffuse large B-cell lymphoma stage II is a fast-growing blood cancer that affects lymph nodes on the same side of the diaphragm. While this cancer is aggressive, it is often treatable and curable, especially with early diagnosis and treatment.

  • 1

    Diffuse large B-cell lymphoma stage III

    Diffuse large B-cell lymphoma stage III is a fast-growing blood cancer affecting the lymphatic system, requiring immediate treatment with powerful drug combinations that can often lead to remission and cure.

  • 1

    Diffuse large B-cell lymphoma stage IV

    Stage 4 diffuse large B-cell lymphoma is an advanced form of blood cancer where the disease has spread beyond the lymphatic system to other organs of the body. Despite its aggressive nature, this cancer often responds well to treatment, and many people can achieve remission or even be cured.

  • 6

    Dilated cardiomyopathy

    Dilated cardiomyopathy is a disease where the heart muscle stretches and weakens, making it harder for the heart to pump blood effectively throughout the body. While some people may not notice symptoms at first, this condition can become life-threatening and is a common cause of heart failure.

  • 2

    Diminished ovarian reserve

    Diminished ovarian reserve affects about 10 to 30 percent of women seeking help for infertility, yet many who receive this diagnosis can still achieve pregnancy with proper care and treatment options tailored to their individual circumstances.

  • 0

    Diphtheria

    Diphtheria is a serious bacterial infection that can affect your throat, nose, and sometimes skin, creating a thick coating that can block your airway and spread toxins throughout your body.

  • 1

    Diverticulitis

    Diverticulitis is inflammation of small pouches that bulge out through weak spots in the colon wall. While these pouches are common as we age, when they become inflamed or infected, they can cause sudden, severe pain and other serious symptoms that require medical attention.

  • 1

    Dizziness

    Dizziness is one of the most common reasons people visit healthcare professionals, affecting approximately 20% to 30% of people at some point in their lives. While it can be alarming and disruptive to daily life, most cases of dizziness can be effectively treated once the correct cause is identified.

  • 1

    DNA mismatch repair protein gene mutation

    When the body’s natural DNA correction system fails, the consequences can range from increased cancer risk to accelerated aging. Mutations in genes responsible for DNA mismatch repair disrupt one of the cell’s most essential quality control mechanisms.

  • 1

    Double hit lymphoma

    Double hit lymphoma is an aggressive form of cancer that develops from white blood cells called B lymphocytes, characterized by specific genetic changes that make it particularly challenging to treat.

  • 1

    Drug dependence

    Drug dependence is a condition where your body becomes so used to a substance that you need it to function normally, and stopping it makes you feel unwell. While often confused with addiction, dependence can occur even with prescribed medications, and understanding the difference is crucial for recognizing when help is needed.

  • 1

    Drug eruption

    Drug eruptions are skin reactions that happen when your body responds to a medication. While most are mild and disappear after stopping the medicine, some can become serious and even life-threatening, requiring immediate medical attention.

  • 8

    Drug use disorder

    Drug use disorder is a treatable mental health condition where you experience a problematic pattern of substance use that affects your health, relationships, and daily life. While it can be life-threatening, recovery is possible for everyone with the right support and treatment.

  • 3

    Dry age-related macular degeneration

    Dry age-related macular degeneration is a common eye condition that affects central vision, particularly in people over 50. While it progresses slowly and doesn’t cause complete blindness, understanding this condition and how to manage it can help preserve your quality of life and independence.

  • 8

    Dry eye

    Dry eye is a common condition that affects millions of people when tears cannot properly lubricate the eyes, causing discomfort and sometimes affecting vision. Understanding the causes and available treatments can help you find relief and protect your eye health.

  • 2

    Dry mouth

    Dry mouth, also called xerostomia, occurs when your salivary glands don’t produce enough saliva to keep your mouth wet. While everyone experiences occasional dry mouth when nervous or stressed, persistent dryness can make chewing, swallowing, and speaking difficult, and significantly increases your risk of tooth decay and oral infections.