Explore popular diseases in clinical trials

Check which popular diseases are currently being frequently studied.

See also our rare diseases glossary and drug database.

Starting by letter

To open the diseases glossary, select a letter from the list below.

Most popular diseases

The list below features the most popular diseases currently involved in ongoing clinical trials.

Disease trials
Non-small cell lung cancer 240
Breast cancer 99
Obesity 92
Prostate cancer 77
Colorectal cancer 69
Ovarian cancer 68
Crohn’s disease 67
Non-small cell lung cancer metastatic 64
Rheumatoid arthritis 55
Squamous cell carcinoma of head and neck 54
Triple negative breast cancer 54
Chronic kidney disease 50
Asthma 50
Hepatocellular carcinoma 47
Neoplasm 47
Acute myeloid leukaemia 47
Colorectal cancer metastatic 46
Overweight 45
Multiple sclerosis 43
Colitis ulcerative 40
Parkinson’s disease 40
HER2 positive breast cancer 39
Gastric cancer 38
Myelodysplastic syndrome 38
Dementia Alzheimer’s type 37
Glioblastoma 36
Bladder cancer 34
Atrial fibrillation 34
Prostate cancer metastatic 34
Renal transplant 33
Ischaemic stroke 33
Diffuse large B-cell lymphoma 32
Chronic obstructive pulmonary disease 32
Head and neck cancer 32
Non-small cell lung cancer stage IV 31
Breast cancer metastatic 30
Coronary artery disease 29
Myasthenia gravis 29
Malignant melanoma 29
Endometrial cancer 28
Cholangiocarcinoma 28
Rectal cancer 27
Pulmonary arterial hypertension 27
Dermatitis atopic 27
Idiopathic pulmonary fibrosis 27
Soft tissue sarcoma 26
Non-small cell lung cancer stage III 26
Plasma cell myeloma 25
Pancreatic carcinoma 25
Small cell lung cancer extensive stage 25
Sepsis 25
Renal cell carcinoma 25
Schizophrenia 24
COVID-19 24
Duchenne muscular dystrophy 24
Non-small cell lung cancer stage IIIB 24
Follicular lymphoma 24
Hormone receptor positive breast cancer 24
Fallopian tube cancer 23
Amyotrophic lateral sclerosis 23
Mantle cell lymphoma 23
Influenza 22
Neoplasm malignant 22
Chronic lymphocytic leukaemia 21
Acute myocardial infarction 21
Major depression 21
Small cell lung cancer 21
Sickle cell disease 21
Interstitial lung disease 21
Cystic fibrosis 21
Breast cancer female 20
Osteoarthritis 20
Glioma 20
Neuroblastoma 20
Chronic rhinosinusitis with nasal polyps 20
Oesophageal adenocarcinoma 20
Myelofibrosis 19
B-cell lymphoma 19
Critical illness 18
Procedural pain 18
Acute kidney injury 18
Psoriasis 18
Axial spondyloarthritis 18
Acute coronary syndrome 17
Vitiligo 17
Hereditary angioedema 17
Relapsing-remitting multiple sclerosis 17
Ewing’s sarcoma 17
IgA nephropathy 17
Gastrooesophageal cancer 16
Juvenile idiopathic arthritis 16
Cardiac failure 16
Uveal melanoma 16
Chronic hepatitis B 16
Allogenic stem cell transplantation 15
Giant cell arteritis 15
Chronic spontaneous urticaria 15
Cardiac arrest 15
Septic shock 14
Malignant melanoma stage III 14

All diseases

  • 36

    Myelodysplastic syndrome

    Myelodysplastic syndrome is a group of disorders that disrupts normal blood cell production in the bone marrow, leaving the body without enough healthy blood cells to function properly. While some people live with the condition for years without treatment, others may see it progress to a more aggressive form of cancer.

  • 1

    Myelodysplastic syndrome transformation

    Myelodysplastic syndrome (MDS) is a group of blood disorders that can progress to a more serious form of cancer. Understanding what happens when MDS transforms into acute myeloid leukemia and what affects the outcome can help patients and families prepare for the challenges ahead.

  • 0

    Myelodysplastic syndrome with excess blasts

    Myelodysplastic syndrome with excess blasts is a high-risk form of a blood disorder where the bone marrow produces too many immature blood cells and not enough healthy ones, often leading to serious complications.

  • 20

    Myelofibrosis

    Myelofibrosis is a rare type of bone marrow cancer where scar tissue gradually replaces the healthy tissue that makes blood cells, leading to serious complications and changes in daily life that require careful management and support.

  • 0

    Myeloid leukaemia

    Myeloid leukaemia is a type of blood cancer that begins in the bone marrow and affects blood cells. It develops rapidly and requires urgent treatment, but newer treatments are helping more people live longer with this condition.

  • 5

    Myeloproliferative neoplasm

    Myeloproliferative neoplasms are rare blood cancers that happen when your bone marrow makes too many blood cells—but with the right treatment, many people can manage these conditions and enjoy a near-normal lifespan.

  • 10

    Myocardial infarction

    A myocardial infarction, commonly known as a heart attack, is a serious medical emergency that occurs when blood flow to part of the heart muscle stops or becomes severely reduced, causing the heart tissue to die from lack of oxygen.

  • 3

    Myocardial ischaemia

    Myocardial ischaemia is a serious condition where your heart muscle doesn’t get enough oxygen-rich blood to work properly. This happens when the arteries that supply blood to your heart become narrowed or blocked, often by a buildup of fatty deposits called plaque.

  • 4

    Myocarditis

    Myocarditis is an inflammation of the heart muscle that can reduce the heart’s ability to pump blood effectively. While the condition affects thousands of people each year, many individuals and even some physicians are unfamiliar with it, making proper diagnosis and treatment essential for recovery.

  • 1

    Myocarditis post infection

    Myocarditis post infection is inflammation of the heart muscle that develops after a viral or other infection. While this condition can be worrying, most people make a very good recovery with proper treatment and care.

  • 2

    Myofascial pain syndrome

    Myofascial pain syndrome is a long-term pain condition affecting muscles and the thin tissue that surrounds them. It causes deep, aching pain that doesn’t go away with rest, often centered around sensitive knots in the muscles called trigger points.

  • 10

    Myopia

    Myopia is a common eye condition affecting millions worldwide, where distant objects appear blurry while close objects remain clear. Understanding this condition and the available treatment options can help protect your vision and reduce the risk of serious eye problems later in life.

  • 0

    Myositis

    Myositis is a rare disease that makes your immune system attack your own muscles, causing chronic inflammation that leads to muscle weakness and fatigue. While there is no cure, treatment can help manage symptoms and improve quality of life.

  • 1

    Myotonia

    Myotonia is a condition where muscles struggle to relax after contracting, causing stiffness and delayed movement. While this disorder can significantly impact daily activities, understanding its various forms and available treatments helps people manage their symptoms and maintain quality of life.

  • 5

    Myotonic dystrophy

    Myotonic dystrophy is a complex inherited condition that affects muscles and many other parts of the body. People with this condition experience progressive muscle weakness, difficulty relaxing muscles after contraction, and a range of other symptoms that can affect the heart, eyes, and other organs.

  • 1

    Myxofibrosarcoma

    Myxofibrosarcoma is a type of cancer that starts in the connective tissue, most commonly appearing as a slow-growing lump in the arms or legs. This cancer primarily affects older adults and has a tendency to return even after treatment, making careful monitoring essential for those diagnosed with this condition.

  • 4

    Myxoid liposarcoma

    Myxoid liposarcoma is a rare cancer that develops in fat cells, most commonly appearing as a slow-growing lump in the legs or arms. Many people carry this condition for years without noticing symptoms, as it typically grows quietly before becoming visible under the skin.

  • 1

    Naevoid melanoma

    Naevoid melanoma is a rare and dangerous type of skin cancer that looks deceptively harmless, often resembling an ordinary mole. This similarity makes it one of the most difficult melanomas to identify, which can lead to delayed diagnosis and treatment.

  • 0

    Naevus flammeus

    Naevus flammeus, also called a port wine stain, is a permanent birthmark that appears as a pink or red patch on a newborn’s skin. Named because it looks like wine has been spilled on the skin, this harmless mark is present in about 3 out of every 1,000 babies and grows with the child throughout life.

  • 10

    Narcolepsy

    Narcolepsy is a chronic brain condition that disrupts the ability to control when you sleep and wake. People with this disorder often experience overwhelming sleepiness during the day and may fall asleep suddenly, along with other symptoms that can significantly affect daily life. While narcolepsy presents serious challenges, it responds well to treatment, allowing many people to manage the condition effectively.

  • 2

    Nasal sinus cancer

    Nasal and sinus cancer is a rare condition that develops in the space behind your nose or in the hollow air-filled spaces around it, often causing symptoms that may seem like ordinary sinus problems at first.

  • 4

    Nasopharyngeal cancer

    Nasopharyngeal cancer is a rare type of cancer that starts in the upper part of the throat, behind the nose. While uncommon in most parts of the world, it occurs much more frequently in certain regions of Asia and Africa. Early symptoms can be hard to recognize, but understanding this disease and its treatment options can help patients and their families navigate the journey ahead.

  • 1

    Nasopharyngeal cancer recurrent

    Recurrent nasopharyngeal cancer presents a difficult challenge for patients and their care teams, with treatment options depending on where the cancer returns and what therapies were used initially.

  • 1

    Neck pain

    Neck pain is a widespread problem affecting millions of people, often caused by everyday habits like poor posture or stress, though it typically improves with simple treatments and self-care.

  • 1

    Necrotising enterocolitis neonatal

    Necrotizing enterocolitis is a life-threatening intestinal illness that primarily strikes premature babies, causing inflammation and death of intestinal tissue that can lead to serious infection and requires urgent medical care.

  • 0

    Necrotising myositis

    Necrotising myositis is a rare inflammatory muscle disease where the body’s immune system attacks its own muscle cells, causing them to die. This leads to severe muscle weakness, particularly in the muscles closest to the center of the body, such as the shoulders, hips, and thighs.

  • 1

    Negative symptoms in schizophrenia

    Negative symptoms are a core component of schizophrenia that account for a large part of the long-term disability and poor functional outcomes in patients with the disorder. These symptoms describe a lessening or absence of normal behaviors and functions, and they can be just as disabling—if not more so—than the more dramatic symptoms like hallucinations.

  • 2

    Neonatal alloimmune thrombocytopenia

    Neonatal alloimmune thrombocytopenia is a serious blood disorder that occurs when a mother’s immune system attacks her baby’s platelets during pregnancy or shortly after birth. Although many cases are mild, this condition is the most common cause of severe low platelet counts in newborns and can lead to dangerous bleeding, including life-threatening brain hemorrhage.

  • 0

    Neonatal anoxia

    Neonatal anoxia is a serious condition where a newborn baby’s brain and other organs are completely deprived of oxygen before, during, or shortly after birth, potentially causing permanent brain damage and lifelong disabilities.

  • 1

    Neonatal asphyxia

    Neonatal asphyxia is a serious medical condition where a baby does not receive enough oxygen before, during, or right after birth. This lack of oxygen can cause damage to the brain and other vital organs, leading to long-term health problems or even death. Understanding this condition is essential for parents and families facing its consequences.

  • 0

    Neonatal hyperglycaemia

    Neonatal hyperglycaemia, or high blood sugar in newborn babies, is less common than low blood sugar but requires careful attention because it can increase the risk of serious health problems and even death in affected infants.

  • 4

    Neonatal respiratory distress syndrome

    Neonatal respiratory distress syndrome is a serious breathing problem that primarily affects premature babies whose lungs haven’t fully developed, making it hard for them to get enough oxygen shortly after birth.

  • 2

    Neonatal respiratory failure

    Neonatal respiratory failure is one of the most common reasons newborns need intensive care, affecting their ability to breathe properly and maintain normal oxygen levels in the first hours or days of life.

  • 47

    Neoplasm

    A neoplasm is an abnormal growth of tissue that forms when cells in your body grow and divide faster than they should, creating a mass that can be noncancerous or cancerous.

  • 22

    Neoplasm malignant

    Malignant neoplasms are cancerous tumors that develop when cells grow and divide faster than they should, spreading to nearby tissues and distant parts of the body. Understanding this disease, its different forms, and available treatments can help patients navigate their diagnosis and care.

  • 14

    Neovascular age-related macular degeneration

    Neovascular age-related macular degeneration is a serious eye disease that can cause rapid vision loss when abnormal blood vessels grow behind the central part of your eye’s retina.

  • 1

    Nephroblastoma

    Nephroblastoma, commonly known as Wilms tumor, is the most common kidney cancer in children, typically appearing before the age of five and often first noticed as a painless lump in the abdomen.

  • 0

    Nephrogenic anaemia

    Nephrogenic anaemia is a common blood condition that affects people with kidney disease, occurring when damaged kidneys cannot produce enough of a special hormone needed to make healthy red blood cells.

  • 2

    Nephrolithiasis

    Kidney stones are hard masses made of crystals that form inside the kidneys and can cause severe pain as they move through the urinary tract. While small stones may pass on their own, larger ones may require medical procedures to break them up or remove them.

  • 3

    Nephropathy

    Nephropathy is a broad term for kidney disease or damage that can lead to serious health problems. While it affects millions of people worldwide, early detection and proper management can help slow its progression and protect your overall health.

  • 8

    Nephrotic syndrome

    Nephrotic syndrome is a kidney disorder where your body loses too much protein through urine, causing swelling and other health complications that require careful medical management.

  • 3

    Nervous system disorder

    Your nervous system controls everything you do—from moving and speaking to breathing and thinking. When something goes wrong with this complex network, it can affect your ability to work, learn, and enjoy daily life. With over 600 different disorders that can affect the nervous system, understanding these conditions is the first step toward getting proper care.

  • 3

    Netherton’s syndrome

    Netherton’s syndrome is a rare inherited disorder that affects the skin, hair, and immune system, presenting challenges from birth that can impact every aspect of daily life.

  • 4

    Neuralgia

    Neuralgia is a sharp, stabbing pain that follows the path of a damaged or irritated nerve. This condition can occur anywhere in the body and ranges from mild, temporary discomfort to severe, debilitating pain that significantly impacts quality of life.

  • 20

    Neuroblastoma

    Neuroblastoma is a rare cancer that develops in developing nerve cells and primarily affects young children, with most cases diagnosed before age 5. While this cancer presents unique challenges, advances in treatment have significantly improved outcomes, and some forms may even resolve without intervention.

  • 0

    Neuroblastoma recurrent

    When neuroblastoma returns after treatment or doesn’t respond to initial therapy, families face difficult challenges, but treatments and support are available.

  • 4

    Neurodegenerative disorder

    Neurodegenerative disorders are chronic conditions that gradually damage and destroy parts of the nervous system, especially the brain, affecting more than 50 million people worldwide. While these conditions are permanent and incurable, many are now treatable thanks to medical advances, with current treatments focused on managing symptoms and slowing disease progression.

  • 1

    Neurodermatitis

    Neurodermatitis is a skin condition that creates an intense itch-scratch cycle, where scratching an itchy patch of skin makes it even itchier, leading to thick, leathery patches that can disrupt sleep, daily activities, and quality of life.

  • 3

    Neurodevelopmental disorder

    Neurodevelopmental disorders are a group of conditions that affect how the brain and nervous system develop, usually appearing in early childhood and potentially continuing into adulthood. These disorders can impact thinking, learning, communication, behavior, and movement, affecting millions of children and adults worldwide.

  • 0

    Neuroendocrine cancer of the prostate metastatic

    Neuroendocrine cancer of the prostate metastatic is a rare and aggressive form of prostate cancer that can develop when the disease spreads beyond the prostate gland and becomes resistant to hormone treatments.

  • 10

    Neuroendocrine carcinoma

    Neuroendocrine carcinomas are fast-growing cancers that develop from specialized cells throughout the body, most commonly affecting the digestive system, lungs, and pancreas, with symptoms varying widely depending on where the cancer is located and whether it produces hormones.

  • 5

    Neuroendocrine carcinoma metastatic

    When neuroendocrine tumors spread beyond their original location to other parts of the body, they become metastatic neuroendocrine cancer. While this represents an advanced stage of disease, many treatment options exist to manage symptoms, slow tumor growth, and help patients maintain quality of life for years.

  • 1

    Neuroendocrine carcinoma of prostate

    Neuroendocrine carcinoma of the prostate is a rare and aggressive form of prostate cancer that develops when prostate cells change their behavior and stop responding to hormone-based treatments that normally control prostate cancer growth.

  • 1

    Neuroendocrine carcinoma of the skin

    Neuroendocrine carcinoma of the skin is a rare and aggressive type of skin cancer that most often appears as a rapidly growing bump on sun-exposed areas of the body, particularly in older adults.

  • 1

    Neuroendocrine cell hyperplasia of infancy

    Neuroendocrine cell hyperplasia of infancy is a rare lung disorder that mainly affects babies and young children, causing rapid breathing and low oxygen levels in the blood, though most children gradually improve as they grow.

  • 8

    Neuroendocrine tumour

    Neuroendocrine tumours are rare cancers that develop in specialized cells throughout the body, most commonly affecting the digestive system, lungs, and pancreas. While these tumours can be challenging to diagnose and manage, advances in treatment are helping more people live for years with this condition.

  • 3

    Neuroendocrine tumour of the lung

    Lung neuroendocrine tumours are a rare but important group of cancers that develop in specialized cells within the lungs, with each type having its own characteristics, treatment approaches, and outlook for patients.

  • 4

    Neurofibromatosis

    Neurofibromatosis is a group of genetic conditions that causes tumors to grow on nerves throughout the body. While most tumors are not cancerous, they can affect the skin, nervous system, eyes, and bones, causing a wide range of symptoms from mild skin changes to serious complications that require careful monitoring throughout life.

  • 0

    Neurofibrosarcoma

    Neurofibrosarcoma is a rare cancer that grows in the protective covering around nerves. While the disease is uncommon, people with neurofibromatosis type 1 face a much higher risk of developing these aggressive tumors.

  • 3

    Neurogenic bladder

    Neurogenic bladder is a condition that affects how your bladder works when there’s a problem with your brain, nerves, or spinal cord. While it cannot be cured, there are many ways to manage the symptoms and improve your quality of life.