Explore popular diseases in clinical trials

Check which popular diseases are currently being frequently studied.

See also our rare diseases glossary and drug database.

Starting by letter

To open the diseases glossary, select a letter from the list below.

Most popular diseases

The list below features the most popular diseases currently involved in ongoing clinical trials.

Disease Trials
Non-small cell lung cancer 238
Breast cancer 131
Neoplasm 124
Plasma cell myeloma 122
Acute myeloid leukaemia 102
Neoplasm malignant 91
Prostate cancer 89
Colitis ulcerative 88
Obesity 82
Colorectal cancer metastatic 81
Crohn’s disease 75
Dementia Alzheimer’s type 75
Type 2 diabetes mellitus 71
Ovarian cancer 71
Colorectal cancer 69
Dermatitis atopic 65
Malignant melanoma 65
Breast cancer metastatic 65
Hepatocellular carcinoma 63
Triple negative breast cancer 62
Non-small cell lung cancer metastatic 60
Asthma 60
Chronic lymphocytic leukaemia 59
Squamous cell carcinoma of head and neck 58
Rheumatoid arthritis 58
HIV infection 57
Hormone receptor positive HER2 negative breast cancer 55
Osteoarthritis 55
Chronic kidney disease 50
Renal transplant 50
Pancreatic carcinoma 49
Atrial fibrillation 45
Ischaemic stroke 45
Parkinson’s disease 44
Systemic lupus erythematosus 43
Gastric cancer 43
Multiple sclerosis 42
Psoriasis 41
Oesophageal adenocarcinoma 40
Hormone-refractory prostate cancer 40
Bladder cancer 40
Chronic obstructive pulmonary disease 40
Non-small cell lung cancer stage IV 40
Endometrial cancer 39
Migraine 39
Major depression 38
Overweight 37
Psoriatic arthropathy 37
Myelodysplastic syndrome 36
Glioblastoma 36
Transitional cell carcinoma 36
Cardiac failure 35
Diffuse large B-cell lymphoma 35
Hormone receptor positive breast cancer 33
Systemic scleroderma 33
Type 1 diabetes mellitus 32
COVID-19 32
Cholangiocarcinoma 32
Schizophrenia 32
Prostate cancer metastatic 31
Head and neck cancer 31
Hidradenitis 31
HER2 positive breast cancer 30
Adenocarcinoma pancreas 30
Cervix carcinoma 29
Coronary artery disease 29
Renal cell carcinoma 29
Acute lymphocytic leukaemia 29
Rectal cancer 29
Myasthenia gravis 29
Pulmonary arterial hypertension 28
Oesophageal carcinoma 28
Follicular lymphoma 28
Plasma cell myeloma refractory 28
Pancreatic carcinoma metastatic 27
Depression 27
Bladder transitional cell carcinoma 27
Pneumonia 26
Adenocarcinoma gastric 26
Procedural pain 25
Interstitial lung disease 25
Metastatic malignant melanoma 25
B-cell lymphoma 25
Acute myocardial infarction 25
Myelofibrosis 24
Non-small cell lung cancer stage III 24
Colon cancer 24
Non-small cell lung cancer stage IIIB 24
Amyotrophic lateral sclerosis 24
Idiopathic pulmonary fibrosis 24
Fallopian tube cancer 23
Small cell lung cancer 23
Breast cancer female 23
Sjogren’s syndrome 23
Soft tissue sarcoma 22
Cardiac amyloidosis 22
Lung neoplasm malignant 22
Sepsis 22
Small cell lung cancer extensive stage 22
Endocrine ophthalmopathy 22

All Diseases

  • 1

    Laryngeal cancer

    Laryngeal cancer is a disease where cancer cells grow uncontrollably in the larynx, the voice box in your throat that helps you speak, breathe, and swallow. While symptoms like hoarseness can be easy to mistake for a common cold, understanding the signs and treatment options is crucial for early detection and better outcomes.

  • 0

    Laryngeal cancer stage I

    Stage I laryngeal cancer is the earliest form of cancer affecting the voice box, where the tumor is limited to a small area and has not spread to lymph nodes or distant sites in the body.

  • 0

    Laryngeal cancer stage II

    Stage II laryngeal cancer is an early form of cancer affecting the voice box that has grown beyond the initial area where it started but remains within the larynx and has not spread to lymph nodes or other organs.

  • 0

    Laryngeal cancer stage III

    Stage III laryngeal cancer is a serious condition where cancer has spread beyond the voice box to nearby tissues or lymph nodes, but has not yet reached distant parts of the body. Understanding this stage and the available treatment options can help patients make informed decisions about their care.

  • 1

    Laryngeal leukoplakia

    Laryngeal leukoplakia appears as white patches on the vocal folds and can range from harmless to precancerous or even cancerous. Understanding this condition is crucial because early detection and proper treatment can prevent serious complications.

  • 5

    Laryngeal squamous cell carcinoma

    Laryngeal squamous cell carcinoma is the most common type of cancer affecting the voice box, accounting for the vast majority of laryngeal cancers. This disease develops when thin, flat cells lining the inside of the larynx begin to grow uncontrollably, potentially affecting your ability to speak, breathe, and swallow.

  • 1

    Latent autoimmune diabetes in adults

    Latent autoimmune diabetes in adults (LADA) is a form of diabetes that shares features of both Type 1 and Type 2 diabetes, affecting adults over 30 years old. Often called Type 1.5 diabetes, it develops slowly over months to years and is frequently misdiagnosed as Type 2 diabetes, potentially leading to inappropriate treatment and complications.

  • 1

    Latent tuberculosis

    Latent tuberculosis means you carry tuberculosis bacteria in your body, but they are inactive and cannot make you sick or spread to others. However, without treatment, these sleeping bacteria can wake up and cause active disease.

  • 0

    Leber’s congenital amaurosis

    Leber’s congenital amaurosis is a rare inherited eye disease that causes severe vision loss or blindness in babies and young children. It affects the retina, the light-sensitive tissue at the back of the eye, and is one of the most common causes of inherited blindness in childhood.

  • 1

    Left ventricular dysfunction

    Left ventricular dysfunction occurs when the heart’s main pumping chamber loses its ability to effectively send oxygen-rich blood throughout the body, leading to symptoms that can significantly impact daily life and overall health.

  • 3

    Left ventricular failure

    Left ventricular failure happens when the heart’s main pumping chamber can’t deliver enough blood to the body’s vital organs, causing symptoms that can significantly affect daily life and require ongoing medical care.

  • 2

    Leiomyosarcoma

    Leiomyosarcoma is a rare and aggressive cancer that develops in smooth muscles found in various organs throughout the body. While it can grow quickly and spread to other tissues, early detection and treatment offer the possibility of recovery.

  • 1

    Leiomyosarcoma metastatic

    Metastatic leiomyosarcoma is an aggressive cancer that has spread from its original site to other parts of the body. While this advanced stage presents serious challenges, understanding the disease, treatment options, and survival factors can help patients and their families navigate this difficult journey.

  • 0

    Leiomyosarcoma recurrent

    Recurrent leiomyosarcoma is when this aggressive cancer returns after initial treatment, presenting challenges for patients and their medical teams. Understanding recurrence patterns, treatment options, and factors that influence survival can help patients navigate this difficult journey.

  • 6

    Lennox-Gastaut syndrome

    Lennox-Gastaut syndrome is a severe form of childhood epilepsy that causes multiple types of seizures, developmental delays, and lasting disabilities. While there is no cure, various treatments can help control symptoms and improve quality of life.

  • 2

    Leukaemia

    Leukaemia is a cancer of the blood that starts when abnormal cells multiply rapidly in the bone marrow, crowding out healthy blood cells and affecting the body’s ability to fight infections, carry oxygen, and form blood clots.

  • 1

    Leukocyte adhesion deficiency

    Leukocyte adhesion deficiency is a rare genetic disorder where white blood cells cannot reach infection sites to fight bacteria and other invaders, leading to severe, recurrent infections that often begin in infancy and can be life-threatening.

  • 2

    Leukoencephalopathy

    Leukoencephalopathy refers to disorders affecting the white matter of the brain, the tissue that protects nerve cells and helps them communicate. These conditions can range from rare viral infections in people with weakened immune systems to inherited genetic disorders that progressively damage the brain’s protective coating.

  • 1

    Lichen planopilaris

    Lichen planopilaris is a condition that causes inflammation in the scalp, leading to patches of permanent hair loss through scarring. While the exact cause remains unclear, early treatment is crucial to prevent further damage, as lost hair cannot regrow once the follicles are destroyed.

  • 2

    Lichen planus

    Lichen planus is a skin condition that can cause itchy, flat-topped bumps on your skin and white patches or painful sores inside your mouth. While the exact cause remains unknown, this inflammatory condition affects the skin, mouth, nails, scalp, and genital areas, and often clears up on its own within one to two years.

  • 4

    Lichen sclerosus

    Lichen sclerosus is a long-term skin condition that causes patches of white, itchy skin, most commonly affecting the genital and anal areas. While there’s no cure, treatment can help control symptoms and prevent serious complications like scarring and an increased cancer risk.

  • 1

    Lichenoid keratosis

    Lichenoid keratosis is a small, harmless skin growth that appears as an inflamed spot or thin pigmented patch, usually showing up as a single lesion that may change color from red to purple or brown over time.

  • 1

    Ligament operation

    Surgery to repair damaged ligaments can restore stability and function to injured joints, but the journey from injury to full recovery requires commitment, patience, and proper rehabilitation.

  • 1

    Ligament sprain

    A ligament sprain is one of the most common injuries that can happen to anyone, from athletes to people going about their daily activities. Understanding what happens when a ligament is injured and how to care for it properly can help you recover faster and avoid long-term problems.

  • 0

    Limb reduction defect

    Limb reduction defects occur when a baby is born with a part of or the entire arm or leg missing or not fully formed. This birth defect affects approximately 1 in every 2,100 babies born in the United States, and while the exact causes remain largely unknown, proper treatment and care can help children with these conditions live full and productive lives.

  • 1

    Lip and/or oral cavity cancer

    Lip and oral cavity cancer is a disease that begins in the lips or mouth, and while it affects thousands of Americans each year, many cases can be prevented through lifestyle changes and early detection can significantly improve survival rates.

  • 0

    Lipid metabolism disorder

    When your body cannot properly process fats, harmful amounts can build up, potentially damaging vital organs and increasing your risk of serious health complications.

  • 2

    Lipoprotein metabolism disorder

    Lipoprotein metabolism disorders are conditions where your body cannot properly process fats in the blood, leading to abnormal levels of cholesterol and triglycerides that can increase your risk of heart disease, stroke, and other serious health problems.

  • 2

    Liposarcoma

    Liposarcoma is a rare type of cancer that begins in fat cells and can develop anywhere in the body, though it most commonly appears in the muscles of the limbs or deep within the belly.

  • 1

    Liposarcoma metastatic

    Liposarcoma metastatic is a rare and serious condition where liposarcoma, a cancer that begins in fat cells, spreads from its original location to other parts of the body. Understanding the behavior of different liposarcoma types, their patterns of spread, and available treatment options is crucial for patients facing this challenging diagnosis.

  • 0

    Liposarcoma recurrent

    Recurrent liposarcoma is a challenging condition where the cancer returns after initial treatment, often within the first two years following surgery. Understanding the patterns of recurrence and the importance of close monitoring can help patients and healthcare providers detect and manage this condition more effectively.

  • 3

    Liver disorder

    The liver is your body’s largest internal organ, performing hundreds of vital tasks every day—from filtering toxins to helping digest food. When the liver becomes damaged, it can affect your entire body, but many types of liver damage can be treated, slowed, or even reversed with early action and healthy lifestyle changes.

  • 10

    Liver transplant

    A liver transplant is a life-saving surgery that replaces a diseased or failing liver with a healthy one from a donor. This complex procedure offers patients with end-stage liver disease or acute liver failure the chance for restored health and an extended lifespan.

  • 1

    Liver transplant rejection

    When a new liver is transplanted, the body’s immune system may see it as a foreign threat and try to attack it, a process known as rejection. While modern medicine has significantly reduced rejection rates, understanding this complication remains vital for anyone receiving or caring for someone with a transplanted liver.

  • 1

    Loeys-Dietz syndrome

    Loeys-Dietz syndrome is a genetic condition that affects the body’s connective tissue, causing problems with blood vessels, bones, skin, and other body parts. This disorder can lead to serious complications, especially in the heart and blood vessels, but with proper diagnosis and care, many people with the condition can live full lives.

  • 2

    Low anterior resection syndrome

    Low anterior resection syndrome is a collection of bowel-related symptoms that can significantly affect daily life after rectal cancer surgery. Studies suggest that as many as 60 to 90 percent of people who undergo sphincter-preserving rectal surgery experience these symptoms, which can persist long after recovery from cancer treatment.

  • 0

    Low cardiac output syndrome

    Low cardiac output syndrome is a serious complication that can occur after heart surgery, when the heart temporarily loses its ability to pump enough blood to meet the body’s needs. This condition, most commonly seen in patients recovering from cardiac operations, can lead to significant health problems if not recognized and treated promptly.

  • 0

    Lower limb fracture

    Lower limb fractures are breaks or cracks in the bones of the leg, including the hip, thigh bone, shin bone, calf bone, ankle, and foot. These injuries can happen to anyone through falls, car accidents, or sports activities, and they require immediate medical care to heal properly.

  • 1

    Lumbosacral radiculopathy

    Lumbosacral radiculopathy affects millions of people worldwide, causing pain that radiates from the lower back down through the legs. While it’s a leading cause of disability in younger adults, most cases respond well to treatment without surgery.

  • 4

    Lung adenocarcinoma

    Lung adenocarcinoma is the most common form of lung cancer in the United States, affecting thousands of people each year. While this diagnosis can feel overwhelming, advances in treatment are helping more people live longer and better lives than ever before.

  • 1

    Lung adenocarcinoma stage III

    Stage 3 lung adenocarcinoma is a form of lung cancer that has spread beyond the lung but has not yet reached distant organs. About one-third of people with lung cancer receive their diagnosis at this stage, when the disease is considered locally advanced and requires careful, coordinated treatment involving multiple approaches.

  • 1

    Lung adenocarcinoma stage IV

    Stage IV lung adenocarcinoma represents the most advanced form of this disease, where cancer has spread beyond the lungs to distant parts of the body. While this diagnosis brings significant challenges, advances in treatment options including targeted therapies and immunotherapy continue to improve outcomes for patients.

  • 2

    Lung cancer metastatic

    Metastatic lung cancer occurs when cancer that started in the lungs has spread to other parts of the body. While this advanced stage cannot usually be cured, modern treatments can help control the disease, manage symptoms, and improve quality of life for some time.

  • 1

    Lung carcinoma cell type unspecified recurrent

    Recurrent lung cancer occurs when cancer cells return after successful treatment and a period without detectable signs of disease. Understanding the patterns of recurrence, warning signs, and treatment options can help patients and caregivers navigate this challenging phase of the cancer journey.

  • 3

    Lung disorder

    Lung disorder is a broad term covering health problems that prevent your lungs from working as they should, affecting millions of people worldwide and ranking among the leading causes of death.

  • 22

    Lung neoplasm malignant

    Lung cancer is one of the most common and serious types of cancer, caused by harmful cells in your lungs growing unchecked. While it remains a leading cause of cancer-related deaths, advances in treatments have caused a significant decline in lung cancer deaths in recent years, offering new hope to patients and their families.

  • 1

    Lung squamous cell carcinoma metastatic

    Metastatic squamous cell carcinoma of the lung is an advanced form of cancer that has spread beyond the lungs to other parts of the body, presenting significant challenges for patients and requiring specialized treatment approaches.

  • 0

    Lung squamous cell carcinoma stage III

    Stage 3 squamous cell lung cancer means the disease has spread beyond the lung but has not yet reached distant parts of the body. About one-third of all lung cancer cases are discovered at this stage, which doctors call locally advanced cancer. Treatment usually involves a combination of therapies tailored to each patient’s specific situation.

  • 0

    Lung squamous cell carcinoma stage IV

    Stage 4 squamous cell lung cancer is the most advanced form of this disease, where tumors have spread beyond the lungs to other parts of the body. While this diagnosis brings unique challenges, modern treatments offer hope, and some patients are living longer than ever before with proper medical care.

  • 4

    Lung transplant

    A lung transplant is a major surgical procedure that can greatly improve health and quality of life for people with end-stage lung disease when other treatments have stopped working.

  • 1

    Lung transplant rejection

    Lung transplant rejection is a common complication that occurs when the body’s immune system attacks the newly transplanted lung, treating it as a foreign invader. While rejection affects most lung transplant recipients, many forms are treatable, and understanding the signs and treatments can help patients maintain their health after transplant.

  • 13

    Lupus nephritis

    Lupus nephritis is a serious kidney condition that develops when the body’s immune system mistakenly attacks the kidneys in people with lupus, potentially leading to kidney failure if left untreated.

  • 0

    Lyme disease

    Lyme disease is a bacterial infection spread through the bite of infected blacklegged ticks. While most cases can be successfully treated with antibiotics, early recognition of symptoms is crucial to prevent the infection from spreading to the joints, heart, and nervous system.

  • 1

    Lymphangioleiomyomatosis

    Lymphangioleiomyomatosis (LAM) is a rare lung disease that almost exclusively affects women, causing abnormal cells to grow in the lungs, kidneys, and lymphatic system, leading to breathing difficulties and other serious complications.

  • 1

    Lymphangioma

    Lymphangioma is a rare, noncancerous fluid-filled cyst that typically appears in newborns and young children, most commonly on the head or neck. These growths develop when the lymphatic system doesn’t form properly during fetal development, causing fluid to collect under the skin.

  • 0

    Lymphangiosarcoma

    Lymphangiosarcoma is a rare and aggressive cancer that develops in people with long-standing swelling of the lymph nodes, most commonly affecting the arms. This serious condition requires prompt diagnosis and treatment, though its rarity means it is less well-known than many other cancers.

  • 3

    Lymphatic malformation

    Lymphatic malformations are clusters of abnormal lymph vessels that form fluid-filled cysts under the skin or within body tissues. These noncancerous growths develop before birth and most commonly appear on the head and neck, though they can occur anywhere in the body except the brain.

  • 1

    Lymphocyte adoptive therapy

    Lymphocyte adoptive therapy is a form of immunotherapy that uses a patient’s own immune cells to fight cancer. These cells are collected, grown to large numbers in a laboratory, and then returned to the patient to help destroy tumors.

  • 1

    Lymphocytic leukaemia

    Lymphocytic leukaemia is a cancer affecting white blood cells in the blood and bone marrow, with chronic forms progressing slowly over time and acute forms developing rapidly.

  • 0

    Lymphocytic lymphoma

    Lymphocytic lymphoma, also known as small lymphocytic lymphoma (SLL), is closely related to chronic lymphocytic leukemia (CLL). These are essentially the same disease, differing only in where cancer cells are most concentrated—in the lymph nodes for SLL, or in the blood and bone marrow for CLL.