Explore popular diseases in clinical trials

Check which popular diseases are currently being frequently studied.

See also our rare diseases glossary and drug database.

Starting by letter

To open the diseases glossary, select a letter from the list below.

Most popular diseases

The list below features the most popular diseases currently involved in ongoing clinical trials.

Disease trials
Non-small cell lung cancer 240
Breast cancer 99
Obesity 92
Prostate cancer 77
Colorectal cancer 69
Ovarian cancer 68
Crohn’s disease 67
Non-small cell lung cancer metastatic 64
Rheumatoid arthritis 55
Squamous cell carcinoma of head and neck 54
Triple negative breast cancer 54
Chronic kidney disease 50
Asthma 50
Hepatocellular carcinoma 47
Neoplasm 47
Acute myeloid leukaemia 47
Colorectal cancer metastatic 46
Overweight 45
Multiple sclerosis 43
Colitis ulcerative 40
Parkinson’s disease 40
HER2 positive breast cancer 39
Gastric cancer 38
Myelodysplastic syndrome 38
Dementia Alzheimer’s type 37
Glioblastoma 36
Bladder cancer 34
Atrial fibrillation 34
Prostate cancer metastatic 34
Renal transplant 33
Ischaemic stroke 33
Diffuse large B-cell lymphoma 32
Chronic obstructive pulmonary disease 32
Head and neck cancer 32
Non-small cell lung cancer stage IV 31
Breast cancer metastatic 30
Coronary artery disease 29
Myasthenia gravis 29
Malignant melanoma 29
Endometrial cancer 28
Cholangiocarcinoma 28
Rectal cancer 27
Pulmonary arterial hypertension 27
Dermatitis atopic 27
Idiopathic pulmonary fibrosis 27
Soft tissue sarcoma 26
Non-small cell lung cancer stage III 26
Plasma cell myeloma 25
Pancreatic carcinoma 25
Small cell lung cancer extensive stage 25
Sepsis 25
Renal cell carcinoma 25
Schizophrenia 24
COVID-19 24
Duchenne muscular dystrophy 24
Non-small cell lung cancer stage IIIB 24
Follicular lymphoma 24
Hormone receptor positive breast cancer 24
Fallopian tube cancer 23
Amyotrophic lateral sclerosis 23
Mantle cell lymphoma 23
Influenza 22
Neoplasm malignant 22
Chronic lymphocytic leukaemia 21
Acute myocardial infarction 21
Major depression 21
Small cell lung cancer 21
Sickle cell disease 21
Interstitial lung disease 21
Cystic fibrosis 21
Breast cancer female 20
Osteoarthritis 20
Glioma 20
Neuroblastoma 20
Chronic rhinosinusitis with nasal polyps 20
Oesophageal adenocarcinoma 20
Myelofibrosis 19
B-cell lymphoma 19
Critical illness 18
Procedural pain 18
Acute kidney injury 18
Psoriasis 18
Axial spondyloarthritis 18
Acute coronary syndrome 17
Vitiligo 17
Hereditary angioedema 17
Relapsing-remitting multiple sclerosis 17
Ewing’s sarcoma 17
IgA nephropathy 17
Gastrooesophageal cancer 16
Juvenile idiopathic arthritis 16
Cardiac failure 16
Uveal melanoma 16
Chronic hepatitis B 16
Allogenic stem cell transplantation 15
Giant cell arteritis 15
Chronic spontaneous urticaria 15
Cardiac arrest 15
Septic shock 14
Malignant melanoma stage III 14

All diseases

  • 0

    Ectopic pregnancy

    Ectopic pregnancy is a serious condition where a fertilized egg implants and grows outside the uterus, most often in a fallopian tube. This pregnancy cannot continue normally and requires prompt medical treatment to protect the mother’s life.

  • 4

    Eczema

    Eczema is a common skin condition that causes dry, itchy skin and rashes, affecting more than 31 million people in the United States alone. While there is no cure, understanding your triggers and following proper treatment can help you manage symptoms and live more comfortably.

  • 4

    EGFR gene mutation

    The EGFR gene mutation is one of the most important genetic changes found in lung cancer, offering hope for patients through targeted treatments that specifically attack cancer cells while sparing healthy tissue.

  • 0

    Ehlers-Danlos syndrome

    Ehlers-Danlos syndrome is a group of inherited disorders that affect the connective tissue throughout your body, causing symptoms like overly flexible joints, stretchy skin, and easy bruising that can significantly impact daily life.

  • 1

    Ejection fraction normal

    Understanding ejection fraction is key to knowing how well your heart pumps blood with each beat. A normal ejection fraction is a sign of a healthy, functioning heart that meets your body’s needs.

  • 1

    Elderly

    The world’s population is aging at an unprecedented pace, with people living longer than ever before. By 2030, one in six people globally will be aged 60 years or over, creating both opportunities and challenges for individuals, families, and healthcare systems.

  • 0

    Electrocardiogram ST segment elevation

    ST segment elevation on an electrocardiogram can signal a life-threatening heart attack requiring immediate treatment, but it can also appear in several other conditions that are less urgent. Understanding the difference is crucial for proper medical care.

  • 0

    Electrocorticogram

    Electrocorticography is a specialized brain monitoring technique that uses electrodes placed directly on the surface of the brain to record electrical activity. This invasive procedure provides much clearer and more detailed information than standard brain wave tests, making it a valuable tool for treating severe epilepsy and advancing our understanding of how the brain works.

  • 0

    Electronic cigarette user

    Electronic cigarettes, commonly called vapes or e-cigarettes, are battery-operated devices that create an aerosol for users to inhale. While often viewed as less harmful than traditional cigarettes, these devices carry their own health risks and have become particularly concerning among young people.

  • 0

    Embolic stroke

    An embolic stroke happens when a blood clot travels through your bloodstream and blocks a blood vessel in your brain, cutting off oxygen and causing brain cells to die. This is a life-threatening emergency that requires immediate medical attention—every second counts in saving lives and preventing permanent brain damage.

  • 2

    Embolism

    An embolism is a blockage in a blood vessel that can happen anywhere in your body, most commonly in the lungs. This serious condition requires immediate medical attention, as it stops blood flow and prevents oxygen from reaching vital organs and tissues.

  • 4

    Embolism venous

    Venous thromboembolism is a serious condition where blood clots form in the veins and can block blood flow, potentially traveling to the lungs and becoming life-threatening. Understanding the warning signs and risk factors can help you seek timely medical care and prevent serious complications.

  • 1

    Emphysema

    Emphysema is a long-term lung condition that makes breathing difficult and gets worse over time, but with the right treatment and lifestyle changes, many people can manage their symptoms and maintain a good quality of life.

  • 2

    Encephalitis autoimmune

    Autoimmune encephalitis is a group of conditions where the body’s immune system mistakenly attacks healthy brain cells, causing inflammation that can lead to memory loss, seizures, psychiatric symptoms, and other serious neurological problems.

  • 0

    Encephalitis Japanese B

    Japanese encephalitis is a serious mosquito-borne viral infection that primarily affects rural areas of Asia and the Western Pacific. While most people infected show no symptoms, those who develop brain inflammation face life-threatening complications, with up to one in four dying from the disease.

  • 1

    Encephalopathy neonatal

    Neonatal encephalopathy is a serious condition affecting newborns that occurs when the brain does not function normally in the earliest days of life, often marked by altered consciousness, seizures, poor muscle tone, and breathing difficulties.

  • 9

    End stage renal disease

    End stage renal disease is a serious condition where your kidneys no longer work well enough to keep you alive without medical help. When this happens, dangerous levels of waste products and fluids build up in your body, requiring dialysis or a kidney transplant to survive.

  • 2

    Endocarditis

    Endocarditis is a rare but life-threatening infection that attacks the inner lining of your heart’s chambers and valves. While uncommon, affecting only about 5 to 7 cases per 100,000 people each year, this serious condition requires immediate medical attention and can be fatal without proper treatment.

  • 1

    Endocarditis bacterial

    Bacterial endocarditis is a serious infection of the heart’s inner lining and valves that can lead to death if not treated promptly, but with early diagnosis and proper antibiotics, many people survive and recover.

  • 1

    Endocarditis enterococcal

    Enterococcal endocarditis is a serious infection of the heart’s inner lining and valves caused by Enterococcus bacteria, particularly Enterococcus faecalis. This condition primarily affects elderly and fragile patients and requires prolonged antibiotic treatment to prevent life-threatening complications.

  • 0

    Endocrine disorder

    Endocrine disorders affect the network of glands that produce and release hormones, leading to imbalances that can impact metabolism, growth, mood, reproduction, and many other vital body functions.

  • 12

    Endocrine ophthalmopathy

    Endocrine ophthalmopathy is an autoimmune condition that affects the tissues around the eyes, causing swelling, inflammation, and sometimes bulging of the eyes. It most commonly occurs in people with Graves’ disease, an overactive thyroid condition, though it can also develop in people with normal or underactive thyroid function.

  • 1

    Endolymphatic hydrops

    Endolymphatic hydrops is a disorder of the inner ear caused by an excessive buildup of fluid that affects both hearing and balance, leading to symptoms like dizziness, hearing loss, and ringing in the ears.

  • 4

    Endometrial adenocarcinoma

    Endometrial adenocarcinoma is a type of cancer that begins in the inner lining of the uterus and represents the most common gynecologic malignancy affecting women in the United States.

  • 28

    Endometrial cancer

    Endometrial cancer is a type of cancer that begins in the lining of the uterus and is the most common gynecologic cancer affecting women in the United States. While it can be a serious diagnosis, it’s often found early because it causes noticeable symptoms like unusual vaginal bleeding, which allows for timely treatment.

  • 3

    Endometrial cancer metastatic

    Metastatic endometrial cancer occurs when cancer that begins in the lining of the uterus spreads to other parts of the body. While this advanced stage presents serious challenges, newer treatments are helping to slow cancer growth, manage symptoms, and improve quality of life for many patients.

  • 4

    Endometrial cancer recurrent

    Recurrent endometrial cancer occurs when cancer returns after successful treatment, often within the first three years. While this diagnosis can be challenging, understanding what to expect and the available treatment options can help you work with your healthcare team to manage your condition.

  • 2

    Endometrial cancer stage I

    Stage 1 endometrial cancer is confined to the uterus and has an excellent outlook, with around 95 percent of people surviving at least five years after diagnosis.

  • 2

    Endometrial cancer stage II

    Stage 2 endometrial cancer has spread beyond the innermost lining of the uterus but remains confined within the uterus itself, offering a strong chance of successful treatment through surgery and additional therapies.

  • 2

    Endometrial cancer stage III

    Stage 3 endometrial cancer means the cancer has grown beyond the uterus but remains within the pelvis, requiring specialized treatment to give patients the best chance of recovery.

  • 1

    Endometrial cancer stage IV

    Stage IV endometrial cancer represents the most advanced form of this disease, where cancer has spread beyond the uterus to nearby organs or distant parts of the body. While this diagnosis presents significant challenges, understanding your condition and the available treatment options can help you make informed decisions about your care.

  • 0

    Endometrial stromal sarcoma

    Endometrial stromal sarcoma is a rare type of cancer that develops in the connective tissue of the uterine lining, affecting primarily women between ages 40 and 60.

  • 8

    Endometriosis

    Endometriosis affects an estimated 10% of women of reproductive age worldwide—approximately 190 million people—causing chronic pain, heavy bleeding, and often years of uncertainty before diagnosis. This condition occurs when tissue similar to the lining of the uterus grows in places where it doesn’t belong, leading to inflammation, scarring, and symptoms that can profoundly impact daily life.

  • 2

    Endotracheal intubation

    Endotracheal intubation is a lifesaving medical procedure where a healthcare provider inserts a breathing tube through your mouth or nose into your windpipe to help you breathe when you cannot do so on your own.

  • 0

    Enteritis

    Enteritis is inflammation of the small intestine that can cause diarrhea, abdominal pain, and fever. While most cases clear up on their own within a few days, understanding the different types and causes can help you know when to seek medical attention.

  • 1

    Eosinophilic gastritis

    Eosinophilic gastritis is a rare, chronic disease where a type of white blood cell called eosinophils accumulates in excessive amounts in the stomach, causing inflammation and damage that can lead to symptoms like nausea, stomach pain, and difficulty eating.

  • 6

    Eosinophilic granulomatosis with polyangiitis

    Eosinophilic granulomatosis with polyangiitis is a rare disorder that causes inflammation in blood vessels throughout the body, primarily affecting people who have asthma or severe allergies.

  • 4

    Eosinophilic oesophagitis

    Eosinophilic oesophagitis is a chronic condition where a type of white blood cell called eosinophils builds up in the tube connecting your mouth to your stomach, causing inflammation that can make swallowing difficult and painful.

  • 2

    Ependymoma

    Ependymoma is a type of tumor that forms in the brain or spinal cord, developing from cells that line the fluid-filled spaces in the central nervous system. While some ependymomas grow slowly and are considered noncancerous, others grow more quickly and are cancerous, requiring a combination of treatments including surgery, radiation, and sometimes chemotherapy.

  • 1

    Ependymoma malignant

    Malignant ependymoma is a fast-growing tumor that forms in the brain or spinal cord, arising from specialized cells that line fluid-filled spaces in the central nervous system. While these tumors can affect people at any age, understanding their characteristics, symptoms, and treatment options is essential for managing this serious condition.

  • 2

    Epicondylitis

    Epicondylitis, commonly known as tennis elbow, causes pain on the outside of the elbow due to overuse of forearm muscles. Despite its name, most people who develop this condition don’t play tennis – it affects anyone who performs repetitive gripping or wrist movements.

  • 6

    Epidermolysis bullosa

    Epidermolysis bullosa is a rare inherited condition that causes the skin to become extremely fragile, blistering and tearing from even the slightest touch or friction.

  • 11

    Epilepsy

    Epilepsy is a chronic brain disorder that causes repeated seizures affecting around 50 million people worldwide. While there is currently no cure, up to 70% of people with epilepsy can live seizure-free with proper treatment and management.

  • 0

    Epilepsy with myoclonic-atonic seizures

    Epilepsy with myoclonic-atonic seizures is a rare childhood condition that causes multiple types of seizures, especially sudden jerking movements followed by loss of muscle control. These seizures can cause children to fall suddenly, and most children also experience delays or setbacks in their development.

  • 5

    Epileptic encephalopathy

    Epileptic encephalopathy describes severe forms of epilepsy where the seizure activity itself contributes to serious cognitive and behavioral problems beyond what the underlying brain condition might cause alone, often beginning in early childhood and requiring prompt, specialized treatment.

  • 0

    Epiphysiolysis

    Epiphysiolysis is a type of fracture that occurs in the growth plates of children’s bones, where the rounded end of the bone separates or slips from the main bone shaft, often affecting active youngsters during their growing years.

  • 0

    Epithelioid sarcoma

    Epithelioid sarcoma is a rare and aggressive type of soft tissue cancer that often starts as a small, painless lump, usually on the hands, arms, legs, or feet. Though it grows slowly, this cancer is known for being difficult to treat and has a high chance of returning after treatment.

  • 2

    Epstein-Barr virus associated lymphoma

    Epstein-Barr virus, one of the most common viruses in the world, infects approximately 90 to 95% of adults. While most people never experience serious problems from this infection, in rare cases the virus can lead to the development of various types of lymphoma, a cancer that affects white blood cells.

  • 2

    Epstein-Barr virus associated lymphoproliferative disorder

    Epstein-Barr virus associated lymphoproliferative disorder is a group of rare conditions where infection with the common Epstein-Barr virus causes certain white blood cells to multiply excessively, potentially leading to diseases ranging from benign conditions to aggressive cancers.

  • 4

    Epstein-Barr virus infection

    Epstein-Barr virus is one of the most common infections in the world, affecting up to 95% of adults at some point in their lives. While many people never experience symptoms, this highly contagious virus can cause infectious mononucleosis and, in rare cases, has been linked to various cancers and autoimmune conditions.

  • 0

    Epstein-Barr virus infection reactivation

    Once the Epstein-Barr virus enters your body, it stays there for life in a sleeping state. For most people, it remains quiet, but certain triggers can wake it up, leading to symptoms that can range from mild fatigue to more serious health challenges.

  • 3

    Erdheim-Chester disease

    Erdheim-Chester disease is a rare blood cancer that occurs when the body produces too many immune cells called histiocytes, which then accumulate in organs and tissues throughout the body. This condition can range from causing no symptoms at all to life-threatening complications, depending on which organs are affected.

  • 4

    Erectile dysfunction

    Erectile dysfunction is a common condition that affects millions of men, particularly those over 40, but it doesn’t have to be a permanent part of aging. Understanding its causes and available treatments can help restore both physical intimacy and confidence.

  • 1

    Erosive oesophagitis

    Erosive oesophagitis is a condition where the lining of the esophagus becomes damaged and worn away due to repeated exposure to stomach acid, leading to inflammation, painful swallowing, and potentially serious complications if left untreated.

  • 0

    Eructation

    Eructation, commonly known as belching or burping, is a natural way your body releases excess air from your digestive system through your mouth. While everyone experiences this occasionally, sometimes it becomes frequent enough to interfere with daily life and may signal an underlying health concern.

  • 1

    Erythema

    Erythema multiforme is a skin reaction that creates distinctive target-shaped marks on your body, usually triggered by infections or medications. While the rash can be uncomfortable and alarming, most cases resolve on their own within a few weeks.

  • 1

    Erythema migrans

    Erythema migrans is a distinctive expanding rash that appears in over 70 percent of people with Lyme disease, serving as the most recognizable early warning sign of this tick-borne infection.

  • 1

    Erythema multiforme

    Erythema multiforme is a skin condition that causes a distinctive rash that looks like a target or bulls-eye. It is usually triggered by an infection or, less commonly, by certain medications, and typically resolves on its own within a few weeks.

  • 2

    Escherichia infection

    Escherichia coli, or E. coli, is a type of bacteria that naturally lives in the digestive system of humans and animals. While most strains are harmless and even helpful, certain types can cause illnesses ranging from mild stomach upset to life-threatening complications.

  • 1

    Escherichia urinary tract infection

    Urinary tract infections caused by E. coli bacteria are among the most common infections people experience, affecting millions each year and often returning even after treatment.