Aggressive non-Hodgkin lymphomas grow and spread quickly, requiring immediate treatment — but many patients can be cured with intensive combination therapy.
Check which popular diseases are currently being frequently studied.
See also our rare diseases glossary and drug database.
To open the diseases glossary, select a letter from the list below.
The list below features the most popular diseases currently involved in ongoing clinical trials.
Aggressive non-Hodgkin lymphomas grow and spread quickly, requiring immediate treatment — but many patients can be cured with intensive combination therapy.
Indolent non-Hodgkin’s lymphoma is a slow-growing type of blood cancer that develops in the lymphatic system. While it usually cannot be cured in advanced stages, most patients can live for many years with proper management.
Non-obstructive cardiomyopathy is a form of heart muscle disease where the heart thickens but does not block blood flow in the same way as the obstructive form, yet it can still cause serious symptoms and complications that affect daily life.
Non-clear cell renal cell carcinoma represents a diverse group of kidney cancers that behave differently from the more common clear cell type, presenting unique challenges in diagnosis and treatment.
Non-small cell lung cancer is the most common type of lung cancer, accounting for about 80% to 85% of all lung cancer cases. It happens when normal cells in your lungs change and grow out of control, usually developing more slowly than other forms of lung cancer but often spreading before symptoms appear.
When non-small cell lung cancer spreads beyond the lungs to distant parts of the body, it becomes metastatic—a condition that brings unique challenges but also growing hope through advancing treatments and supportive care approaches.
Recurrent non-small cell lung cancer means the cancer has returned after treatment. Even after successful treatment that achieves remission, between 30% and 55% of patients develop recurrence, though modern treatments offer hope and new options for managing the disease when it returns.
Stage I non-small cell lung cancer is an early form of the disease where the tumor is small and has not spread beyond the lung. With proper treatment, many people with this stage have a good chance of living for many years.
Stage II non-small cell lung cancer means doctors have found one or more tumors in your lung that have started to spread, but only within the lung or to nearby lymph nodes. While the cancer is more extensive than stage I, surgery and other treatments can often remove it successfully, giving many patients a good chance at longer survival.
Stage 3 non-small cell lung cancer represents a complex form of lung disease where cancer has spread beyond the lungs to nearby tissues and lymph nodes, but not to distant organs. About 30% of people with non-small cell lung cancer are diagnosed at this stage, facing a challenging but potentially treatable condition.
Stage IIIA non-small cell lung cancer represents a complex middle ground in cancer care—the disease has spread beyond the lungs to nearby lymph nodes but has not reached distant parts of the body. About 30% of people with non-small cell lung cancer are diagnosed at stage 3, facing challenging but potentially treatable disease that requires a carefully coordinated approach from multiple medical specialists.
Stage IIIB non-small cell lung cancer represents an advanced form of the disease where cancer has spread beyond the lung to nearby structures and lymph nodes, yet has not reached distant organs. Understanding this stage and the available treatment options is essential for making informed decisions about care.
Stage IV non-small cell lung cancer means the disease has spread from the lungs to distant areas of the body. Although it usually can’t be cured, a variety of treatments can slow the cancer’s growth and help manage symptoms.
Noninfective chorioretinitis is an inflammatory condition affecting the back of the eye that can seriously threaten your vision if left untreated. Unlike infections, this condition stems from the body’s own immune system or other non-infectious causes.
Noonan syndrome is a genetic condition that affects many parts of the body, causing distinctive facial features, heart problems, short stature, and other health challenges that vary widely from person to person.
Normal pressure hydrocephalus is a brain condition that happens when fluid builds up inside your skull, causing walking problems, memory difficulties, and loss of bladder control. While these symptoms can look like dementia or Parkinson’s disease, this condition is sometimes treatable and even reversible with surgery.
Notalgia paresthetica is a nerve disorder that causes intense itching, burning, or tingling in a specific patch of skin on your upper back, usually between your shoulder blade and spine. Although it can be uncomfortable and frustrating, the condition is not dangerous to your health.
NTRK gene fusions represent a rare but critical genetic change that can drive cancer development across many different types of tumors, affecting both adults and children.