Explore popular diseases in clinical trials

Check which popular diseases are currently being frequently studied.

See also our rare diseases glossary and drug database.

Starting by letter

To open the diseases glossary, select a letter from the list below.

Most popular diseases

The list below features the most popular diseases currently involved in ongoing clinical trials.

Disease trials
Non-small cell lung cancer 228
Breast cancer 94
Obesity 86
Prostate cancer 73
Colorectal cancer 69
Ovarian cancer 66
Non-small cell lung cancer metastatic 66
Crohn’s disease 61
Type 2 diabetes mellitus 54
Rheumatoid arthritis 54
Triple negative breast cancer 52
Hormone receptor positive HER2 negative breast cancer 52
Asthma 51
Acute myeloid leukaemia 50
Squamous cell carcinoma of head and neck 50
Chronic kidney disease 49
Neoplasm 48
Colorectal cancer metastatic 47
Hepatocellular carcinoma 47
Systemic lupus erythematosus 40
Colitis ulcerative 40
Multiple sclerosis 39
Overweight 39
Dementia Alzheimer’s type 39
Gastric cancer 38
Myelodysplastic syndrome 37
Parkinson’s disease 37
HER2 positive breast cancer 37
Glioblastoma 37
Atrial fibrillation 34
Bladder cancer 34
Chronic obstructive pulmonary disease 33
Ischaemic stroke 33
Prostate cancer metastatic 33
Myasthenia gravis 32
Renal transplant 31
Type 1 diabetes mellitus 31
Head and neck cancer 31
Endometrial cancer 31
Malignant melanoma 31
Non-small cell lung cancer stage IV 31
Diffuse large B-cell lymphoma 31
Breast cancer metastatic 31
HIV infection 30
Dermatitis atopic 28
Cholangiocarcinoma 28
Coronary artery disease 28
Plasma cell myeloma 28
Pulmonary arterial hypertension 28
Neoplasm malignant 27
Rectal cancer 27
Renal cell carcinoma 26
Pancreatic carcinoma 26
Schizophrenia 26
Duchenne muscular dystrophy 25
Non-small cell lung cancer stage III 25
Follicular lymphoma 25
COVID-19 25
Migraine 24
Hormone receptor positive breast cancer 24
Idiopathic pulmonary fibrosis 24
Non-small cell lung cancer stage IIIB 24
Sepsis 24
Chronic lymphocytic leukaemia 24
Soft tissue sarcoma 24
Mantle cell lymphoma 23
Small cell lung cancer extensive stage 23
Colon cancer 23
Fallopian tube cancer 23
Influenza 22
Small cell lung cancer 21
Interstitial lung disease 21
Acute myocardial infarction 21
Oesophageal adenocarcinoma 21
Amyotrophic lateral sclerosis 21
Chronic rhinosinusitis with nasal polyps 20
Cystic fibrosis 20
Glioma 20
Myelofibrosis 19
Neuroblastoma 19
B-cell lymphoma 19
Sickle cell disease 19
Major depression 19
Procedural pain 19
Axial spondyloarthritis 18
Osteoarthritis 18
Breast cancer female 17
Critical illness 17
Acute kidney injury 17
Hereditary angioedema 17
Relapsing-remitting multiple sclerosis 16
Acute coronary syndrome 16
IgA nephropathy 16
Psoriasis 16
Gastrooesophageal cancer 16
Ewing’s sarcoma 16
Cardiac failure 16
Vitiligo 16
Transitional cell carcinoma 15
Giant cell arteritis 15

Diseases starting with l

  • 1

    Lung squamous cell carcinoma stage IV

    Stage 4 squamous cell lung cancer is the most advanced form of this disease, where tumors have spread beyond the lungs to other parts of the body. While this diagnosis brings unique challenges, modern treatments offer hope, and some patients are living longer than ever before with proper medical care.

  • 4

    Lung transplant

    A lung transplant is a major surgical procedure that can greatly improve health and quality of life for people with end-stage lung disease when other treatments have stopped working.

  • 2

    Lung transplant rejection

    Lung transplant rejection is a common complication that occurs when the body’s immune system attacks the newly transplanted lung, treating it as a foreign invader. While rejection affects most lung transplant recipients, many forms are treatable, and understanding the signs and treatments can help patients maintain their health after transplant.

  • 14

    Lupus nephritis

    Lupus nephritis is a serious kidney condition that develops when the body’s immune system mistakenly attacks the kidneys in people with lupus, potentially leading to kidney failure if left untreated.

  • 1

    Lyme disease

    Lyme disease is a bacterial infection spread through the bite of infected blacklegged ticks. While most cases can be successfully treated with antibiotics, early recognition of symptoms is crucial to prevent the infection from spreading to the joints, heart, and nervous system.

  • 1

    Lymphangioleiomyomatosis

    Lymphangioleiomyomatosis (LAM) is a rare lung disease that almost exclusively affects women, causing abnormal cells to grow in the lungs, kidneys, and lymphatic system, leading to breathing difficulties and other serious complications.

  • 1

    Lymphangioma

    Lymphangioma is a rare, noncancerous fluid-filled cyst that typically appears in newborns and young children, most commonly on the head or neck. These growths develop when the lymphatic system doesn’t form properly during fetal development, causing fluid to collect under the skin.

  • 1

    Lymphangiosarcoma

    Lymphangiosarcoma is a rare and aggressive cancer that develops in people with long-standing swelling of the lymph nodes, most commonly affecting the arms. This serious condition requires prompt diagnosis and treatment, though its rarity means it is less well-known than many other cancers.

  • 2

    Lymphatic malformation

    Lymphatic malformations are clusters of abnormal lymph vessels that form fluid-filled cysts under the skin or within body tissues. These noncancerous growths develop before birth and most commonly appear on the head and neck, though they can occur anywhere in the body except the brain.

  • 1

    Lymphocyte adoptive therapy

    Lymphocyte adoptive therapy is a form of immunotherapy that uses a patient’s own immune cells to fight cancer. These cells are collected, grown to large numbers in a laboratory, and then returned to the patient to help destroy tumors.

  • 1

    Lymphocytic leukaemia

    Lymphocytic leukaemia is a cancer affecting white blood cells in the blood and bone marrow, with chronic forms progressing slowly over time and acute forms developing rapidly.

  • 0

    Lymphocytic lymphoma

    Lymphocytic lymphoma, also known as small lymphocytic lymphoma (SLL), is closely related to chronic lymphocytic leukemia (CLL). These are essentially the same disease, differing only in where cancer cells are most concentrated—in the lymph nodes for SLL, or in the blood and bone marrow for CLL.

  • 1

    Lymphoedema

    Lymphoedema is a chronic condition causing swelling in the body’s tissues that can affect any part of the body, though it most commonly occurs in the arms and legs. While there is no cure, the condition can be managed through various treatments and lifestyle changes.

  • 5

    Lymphoma

    Lymphoma is a type of blood cancer that starts in white blood cells called lymphocytes, affecting the lymphatic system that helps protect your body from infection. It’s the fifth most common type of cancer, with over 14,000 people diagnosed each year in the UK alone, but thanks to modern treatments, many patients can live long and healthy lives.

  • 0

    Lysosomal storage disorder

    Lysosomal storage disorders are rare genetic conditions where the body’s cells cannot properly break down fats, sugars, and other substances, leading to a toxic buildup that can damage organs throughout the body.