Explore popular diseases in clinical trials

Check which popular diseases are currently being frequently studied.

See also our rare diseases glossary and drug database.

Starting by letter

To open the diseases glossary, select a letter from the list below.

Most popular diseases

The list below features the most popular diseases currently involved in ongoing clinical trials.

Disease Trials
Non-small cell lung cancer 238
Breast cancer 131
Neoplasm 124
Plasma cell myeloma 122
Acute myeloid leukaemia 102
Neoplasm malignant 91
Prostate cancer 89
Colitis ulcerative 87
Obesity 81
Colorectal cancer metastatic 80
Crohn’s disease 76
Dementia Alzheimer’s type 75
Type 2 diabetes mellitus 71
Ovarian cancer 71
Colorectal cancer 69
Dermatitis atopic 66
Malignant melanoma 65
Breast cancer metastatic 65
Hepatocellular carcinoma 63
Triple negative breast cancer 62
Chronic lymphocytic leukaemia 60
Asthma 60
Non-small cell lung cancer metastatic 59
Rheumatoid arthritis 58
Squamous cell carcinoma of head and neck 58
HIV infection 57
Hormone receptor positive HER2 negative breast cancer 55
Osteoarthritis 55
Renal transplant 50
Chronic kidney disease 49
Pancreatic carcinoma 49
Ischaemic stroke 45
Parkinson’s disease 44
Atrial fibrillation 44
Systemic lupus erythematosus 43
Gastric cancer 42
Multiple sclerosis 42
Oesophageal adenocarcinoma 40
Hormone-refractory prostate cancer 40
Bladder cancer 40
Chronic obstructive pulmonary disease 40
Psoriasis 40
Non-small cell lung cancer stage IV 40
Migraine 39
Endometrial cancer 38
Major depression 38
Psoriatic arthropathy 37
Overweight 36
Myelodysplastic syndrome 36
Glioblastoma 36
Transitional cell carcinoma 36
Cardiac failure 35
Diffuse large B-cell lymphoma 35
Hormone receptor positive breast cancer 33
Systemic scleroderma 33
Type 1 diabetes mellitus 32
COVID-19 32
Cholangiocarcinoma 32
Schizophrenia 32
Head and neck cancer 31
Hidradenitis 31
Prostate cancer metastatic 31
HER2 positive breast cancer 30
Adenocarcinoma pancreas 30
Myasthenia gravis 30
Cervix carcinoma 29
Coronary artery disease 29
Acute lymphocytic leukaemia 29
Renal cell carcinoma 29
Rectal cancer 29
Pulmonary arterial hypertension 28
Follicular lymphoma 28
Plasma cell myeloma refractory 28
Pancreatic carcinoma metastatic 27
Oesophageal carcinoma 27
Depression 27
Bladder transitional cell carcinoma 27
Adenocarcinoma gastric 26
Pneumonia 26
Procedural pain 25
Interstitial lung disease 25
Metastatic malignant melanoma 25
B-cell lymphoma 25
Acute myocardial infarction 25
Myelofibrosis 24
Non-small cell lung cancer stage III 24
Colon cancer 24
Amyotrophic lateral sclerosis 24
Non-small cell lung cancer stage IIIB 24
Idiopathic pulmonary fibrosis 24
Fallopian tube cancer 23
Small cell lung cancer 23
Breast cancer female 23
Sjogren’s syndrome 23
B-cell small lymphocytic lymphoma 22
Soft tissue sarcoma 22
Cardiac amyloidosis 22
Lung neoplasm malignant 22
Sepsis 22
Small cell lung cancer extensive stage 22

Diseases starting with l

  • 0

    Lung squamous cell carcinoma stage IV

    Stage 4 squamous cell lung cancer is the most advanced form of this disease, where tumors have spread beyond the lungs to other parts of the body. While this diagnosis brings unique challenges, modern treatments offer hope, and some patients are living longer than ever before with proper medical care.

  • 4

    Lung transplant

    A lung transplant is a major surgical procedure that can greatly improve health and quality of life for people with end-stage lung disease when other treatments have stopped working.

  • 1

    Lung transplant rejection

    Lung transplant rejection is a common complication that occurs when the body’s immune system attacks the newly transplanted lung, treating it as a foreign invader. While rejection affects most lung transplant recipients, many forms are treatable, and understanding the signs and treatments can help patients maintain their health after transplant.

  • 13

    Lupus nephritis

    Lupus nephritis is a serious kidney condition that develops when the body’s immune system mistakenly attacks the kidneys in people with lupus, potentially leading to kidney failure if left untreated.

  • 0

    Lyme disease

    Lyme disease is a bacterial infection spread through the bite of infected blacklegged ticks. While most cases can be successfully treated with antibiotics, early recognition of symptoms is crucial to prevent the infection from spreading to the joints, heart, and nervous system.

  • 1

    Lymphangioleiomyomatosis

    Lymphangioleiomyomatosis (LAM) is a rare lung disease that almost exclusively affects women, causing abnormal cells to grow in the lungs, kidneys, and lymphatic system, leading to breathing difficulties and other serious complications.

  • 1

    Lymphangioma

    Lymphangioma is a rare, noncancerous fluid-filled cyst that typically appears in newborns and young children, most commonly on the head or neck. These growths develop when the lymphatic system doesn’t form properly during fetal development, causing fluid to collect under the skin.

  • 0

    Lymphangiosarcoma

    Lymphangiosarcoma is a rare and aggressive cancer that develops in people with long-standing swelling of the lymph nodes, most commonly affecting the arms. This serious condition requires prompt diagnosis and treatment, though its rarity means it is less well-known than many other cancers.

  • 3

    Lymphatic malformation

    Lymphatic malformations are clusters of abnormal lymph vessels that form fluid-filled cysts under the skin or within body tissues. These noncancerous growths develop before birth and most commonly appear on the head and neck, though they can occur anywhere in the body except the brain.

  • 1

    Lymphocyte adoptive therapy

    Lymphocyte adoptive therapy is a form of immunotherapy that uses a patient’s own immune cells to fight cancer. These cells are collected, grown to large numbers in a laboratory, and then returned to the patient to help destroy tumors.

  • 1

    Lymphocytic leukaemia

    Lymphocytic leukaemia is a cancer affecting white blood cells in the blood and bone marrow, with chronic forms progressing slowly over time and acute forms developing rapidly.

  • 0

    Lymphocytic lymphoma

    Lymphocytic lymphoma, also known as small lymphocytic lymphoma (SLL), is closely related to chronic lymphocytic leukemia (CLL). These are essentially the same disease, differing only in where cancer cells are most concentrated—in the lymph nodes for SLL, or in the blood and bone marrow for CLL.

  • 1

    Lymphoedema

    Lymphoedema is a chronic condition causing swelling in the body’s tissues that can affect any part of the body, though it most commonly occurs in the arms and legs. While there is no cure, the condition can be managed through various treatments and lifestyle changes.

  • 5

    Lymphoma

    Lymphoma is a type of blood cancer that starts in white blood cells called lymphocytes, affecting the lymphatic system that helps protect your body from infection. It’s the fifth most common type of cancer, with over 14,000 people diagnosed each year in the UK alone, but thanks to modern treatments, many patients can live long and healthy lives.

  • 0

    Lysosomal storage disorder

    Lysosomal storage disorders are rare genetic conditions where the body’s cells cannot properly break down fats, sugars, and other substances, leading to a toxic buildup that can damage organs throughout the body.