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Ropivacaine

Clinical trials investigating Ropivacaine are studying how it is used in different pain-control procedures. The trials look at safety and effectiveness in patients having ICU pleural drainage, cancer surgery, cardiac surgery, hemorrhoid treatment, and hallux valgus repair.

Table of contents

Trial overview

These clinical trials study Ropivacaine in different procedure settings, mainly to see how well it helps control pain and support recovery.[1][2][3][4][5]

The listed studies are all interventional, which means the research team gives a treatment or compares approaches and then measures the result.[1][2][3][4][5]

Most of the trials are Phase 3 studies, and one is a Low Intervention study.[1][2][3][4][5]

Pain and anesthesia studies

One trial in intensive care studies a serratus plane block during pleural drainage, comparing Ropivacaine with local anesthesia to see how much acute pain patients feel during the procedure.[1]

Another trial in throat and neck cancer surgery studies a superficial cervical plexus block and looks at whether Ropivacaine can reduce the amount of morphine needed during the first 24 hours after surgery.[2]

A third study in hallux valgus repair tests ultrasound-guided ankle blocks and compares different Ropivacaine concentrations to see how long the sensory block lasts over 48 hours.[5]

Surgery and recovery endpoints

In cardiac sternotomy surgery, one study evaluates a parastrenal block and measures whether postoperative lung function is better, using forced vital capacity at day 1 after surgery.[3]

In hemorrhoidal disease, one completed study tested perianal infiltration during radiofrequency treatment and compared pain at 6 hours after the procedure using a visual analogue scale.[4]

These studies focus on short-term outcomes after procedures, such as pain scores, opioid use, breathing tests, and block duration.[1][2][3][4][5]

Who is studied in these trials

The target populations are patients having specific procedures, not a broad group of people with one long-term disease.[1][2][3][4][5]

  • Patients in intensive care who need pleural drainage and pain control during the procedure.[1]
  • Patients having throat and neck cancer surgery, where the study looks at reducing postoperative morphine use.[2]
  • Patients having cardiac sternotomy surgery, where the study checks lung function after surgery.[3]
  • Patients with hemorrhoidal disease who undergo radiofrequency treatment.[4]
  • Patients having hallux valgus repair surgery with ankle block anesthesia.[5]

What the trials measure

The main outcomes are different in each study, but they all focus on practical results that matter to patients.[1][2][3][4][5]

  • Acute pain during pleural drainage, measured with a numerical scale.[1]
  • Amount of morphine used after surgery, including room titration and PCA use.[2]
  • Change in forced vital capacity after cardiac surgery, which shows how well the lungs are working.[3]
  • Pain score at 6 hours after hemorrhoid treatment, measured with VAS.[4]
  • Duration of sensory block after ankle block for hallux valgus repair.[5]

These endpoints help researchers compare whether a block or infiltration technique gives better pain relief, better recovery, or longer numbness where it is needed.[1][2][3][4][5]

Trial ID Phase Condition studied Status Enrollment
NCT03984656 Phase 3 Anesthesia / intensive care Authorised 70
2024-510942-15-00 Phase 3 Cancer surgery Authorised 346
2024-513301-30-00 Phase 3 Cardiac surgery Completed 84
NCT05519189 Low Intervention Hemorrhoidal disease Completed 134
NCT06185608 Phase 3 Hallux valgus Authorised 174

FAQ

  • What are the Ropivacaine trials trying to find out? They are mainly testing whether Ropivacaine helps reduce pain or improve recovery after procedures. Some trials compare it with other local anesthetics or with no active infiltration.
  • Who can take part in these studies? The studies include adults having specific procedures such as pleural drainage, throat and neck cancer surgery, cardiac sternotomy surgery, hemorrhoid treatment, or hallux valgus repair. Each trial has its own eligibility rules.
  • What phases are these Ropivacaine studies? Most of the listed studies are Phase 3 trials. One study is marked as Low Intervention.
  • What conditions are being studied with Ropivacaine? The trials focus on anesthesia and intensive care, cancer surgery, cardiac surgery, hemorrhoidal disease, and hallux valgus. These are procedure-specific studies, not long-term disease treatment studies.
  • What outcomes do the trials measure? The studies measure pain scores, morphine use after surgery, lung function after cardiac surgery, and how long sensory block lasts. These outcomes help show whether the procedure gives better pain relief or recovery.

Ongoing Clinical Trials on Ropivacaine

  • Study on Reducing Morphine Use After Throat and Neck Cancer Surgery Using Ropivacaine and Sodium Chloride for Patients Undergoing Cancer Surgery

    Recruiting

    3 1 1
    Investigated drugs:
    France

  • Study of different ropivacaine concentrations in ankle nerve block for hallux valgus (bunion) surgery patients

    Recruiting

    3 1 1 1
    Investigated drugs:
    Belgium

  • Study of lidocaine hydrochloride, ropivacaine, and sodium chloride on acute pain in healthy adults aged 18‑64

    Not yet recruiting

    3 1 1
    Investigated drugs:
    Norway

  • Study on Pain Relief Using Serratus Plane Block with Ropivacaine, Lidocaine Hydrochloride, and Dexamethasone Sodium Phosphate for Intensive Care Patients Undergoing Pleural Drainage

    Not yet recruiting

    3 1 1 1
    Investigated drugs:
    France

  • Study on the Effect of Ropivacaine on Breathing After Heart Surgery for Patients Undergoing Cardiac Surgery

    Not recruiting

    3 1 1 1
    Investigated drugs:
    France

  • Study on Pain Relief for Hemorrhoids Using Ropivacaine and Ropivacaine Hydrochloride in Patients Undergoing Radiofrequency Treatment

    Not recruiting

    3 1 1 1
    Investigated diseases:
    Investigated drugs:
    France

Glossary

  • Clinical trial: A research study in people that tests a treatment or procedure to see how well it works and how safe it is.
  • Interventional study: A study where researchers give a treatment or procedure and then measure the results.
  • Phase 3: A later stage of testing in a larger group of people to compare benefits and risks more clearly.
  • Low Intervention: A study with a lower level of added risk because it uses routine care or a simple study design.
  • Local anesthesia: A way to numb a small area of the body so a procedure hurts less.
  • Locoregional anesthesia: Anesthesia that blocks pain in a larger body area, such as a limb, chest wall, or neck region.
  • Serratus plane block: A nerve block used on the chest wall to help reduce pain during or after a procedure.
  • Parastrenal block: A pain-blocking technique near the breastbone, often studied for chest surgery pain.
  • Sensory block: A loss of feeling in an area of the body after a nerve block.
  • Visual analogue scale (VAS): A pain rating tool, usually a line or score scale, used to show how strong pain feels.
  • Forced vital capacity (FVC): A breathing test that measures how much air a person can forcefully breathe out after taking a deep breath.
  • PCA morphine: Patient-controlled analgesia, a system that lets a patient give themselves small doses of pain medicine when needed.

References

  1. https://clinicaltrials.gov/study/NCT01558713
  2. https://clinicaltrials.gov/study/NCT03444636
  3. https://clinicaltrials.gov/study/NCT01644864
  4. https://clinicaltrials.gov/study/NCT04199013
  5. https://clinicaltrials.gov/study/NCT03591146
  6. https://clinicaltrials.gov/study/NCT02944526
  7. https://clinicaltrials.gov/study/NCT02439281
  8. https://clinicaltrials.gov/study/NCT04551924
  9. https://clinicaltrials.gov/study/NCT04773301