Explore popular diseases in clinical trials

Check which popular diseases are currently being frequently studied.

See also our rare diseases glossary and drug database.

Starting by letter

To open the diseases glossary, select a letter from the list below.

Most popular diseases

The list below features the most popular diseases currently involved in ongoing clinical trials.

Disease trials
Non-small cell lung cancer 240
Breast cancer 99
Obesity 92
Prostate cancer 77
Colorectal cancer 69
Ovarian cancer 68
Crohn’s disease 67
Non-small cell lung cancer metastatic 64
Rheumatoid arthritis 55
Squamous cell carcinoma of head and neck 54
Triple negative breast cancer 54
Chronic kidney disease 50
Asthma 50
Hepatocellular carcinoma 47
Neoplasm 47
Acute myeloid leukaemia 47
Colorectal cancer metastatic 46
Overweight 45
Multiple sclerosis 43
Colitis ulcerative 40
Parkinson’s disease 40
HER2 positive breast cancer 39
Gastric cancer 38
Myelodysplastic syndrome 38
Dementia Alzheimer’s type 37
Glioblastoma 36
Bladder cancer 34
Atrial fibrillation 34
Prostate cancer metastatic 34
Renal transplant 33
Ischaemic stroke 33
Diffuse large B-cell lymphoma 32
Chronic obstructive pulmonary disease 32
Head and neck cancer 32
Non-small cell lung cancer stage IV 31
Breast cancer metastatic 30
Coronary artery disease 29
Myasthenia gravis 29
Malignant melanoma 29
Endometrial cancer 28
Cholangiocarcinoma 28
Rectal cancer 27
Pulmonary arterial hypertension 27
Dermatitis atopic 27
Idiopathic pulmonary fibrosis 27
Soft tissue sarcoma 26
Non-small cell lung cancer stage III 26
Plasma cell myeloma 25
Pancreatic carcinoma 25
Small cell lung cancer extensive stage 25
Sepsis 25
Renal cell carcinoma 25
Schizophrenia 24
COVID-19 24
Duchenne muscular dystrophy 24
Non-small cell lung cancer stage IIIB 24
Follicular lymphoma 24
Hormone receptor positive breast cancer 24
Fallopian tube cancer 23
Amyotrophic lateral sclerosis 23
Mantle cell lymphoma 23
Influenza 22
Neoplasm malignant 22
Chronic lymphocytic leukaemia 21
Acute myocardial infarction 21
Major depression 21
Small cell lung cancer 21
Sickle cell disease 21
Interstitial lung disease 21
Cystic fibrosis 21
Breast cancer female 20
Osteoarthritis 20
Glioma 20
Neuroblastoma 20
Chronic rhinosinusitis with nasal polyps 20
Oesophageal adenocarcinoma 20
Myelofibrosis 19
B-cell lymphoma 19
Critical illness 18
Procedural pain 18
Acute kidney injury 18
Psoriasis 18
Axial spondyloarthritis 18
Acute coronary syndrome 17
Vitiligo 17
Hereditary angioedema 17
Relapsing-remitting multiple sclerosis 17
Ewing’s sarcoma 17
IgA nephropathy 17
Gastrooesophageal cancer 16
Juvenile idiopathic arthritis 16
Cardiac failure 16
Uveal melanoma 16
Chronic hepatitis B 16
Allogenic stem cell transplantation 15
Giant cell arteritis 15
Chronic spontaneous urticaria 15
Cardiac arrest 15
Septic shock 14
Malignant melanoma stage III 14

Diseases starting with a

  • 1

    Abdominal infection

    Abdominal infections represent a serious medical condition that can range from simple inflammation within the digestive tract to severe, life-threatening complications requiring emergency treatment. These infections are the second most common cause of infectious deaths in intensive care units and can lead to serious conditions like sepsis if not treated promptly.

  • 0

    Abdominal pain

    Abdominal pain is one of the most common reasons people seek medical care, yet most cases resolve on their own without serious intervention. Understanding where the pain occurs, what it feels like, and when to worry can help you know whether you need immediate care or can safely manage your symptoms at home.

  • 1

    Abdominal wall pain

    Abdominal wall pain is often confused with pain from organs inside the abdomen, leading many patients through months of unnecessary tests and procedures before getting the right diagnosis and treatment.

  • 1

    ABO haemolytic disease of newborn

    ABO haemolytic disease of newborn is a blood disorder that occurs when a mother and baby have incompatible blood types from the ABO blood group system. Unlike other forms of this condition, it can affect a firstborn baby and typically causes milder symptoms than similar blood group disorders.

  • 0

    Abortion threatened

    Threatened miscarriage describes vaginal bleeding and cramping during early pregnancy that may—or may not—lead to pregnancy loss. While these symptoms can be frightening, many pregnancies continue successfully, with about 60% reaching full term despite early bleeding.

  • 1

    Acarodermatitis

    Acarodermatitis refers to a group of skin conditions characterized by distinctive rashes that primarily affect the extremities and certain body areas, with causes ranging from genetic disorders to viral infections.

  • 0

    Acne

    Acne is one of the most common skin conditions that affects millions of people worldwide, causing pimples, oily skin, and sometimes scarring that can impact both physical appearance and emotional well-being.

  • 0

    Acoustic neuroma

    An acoustic neuroma is a noncancerous tumor that develops on the nerve connecting your inner ear to your brain, causing symptoms like hearing loss, ringing in the ears, and balance problems that often develop gradually over years.

  • 1

    Acquired antithrombin III deficiency

    Acquired antithrombin III deficiency is a condition where the body doesn’t have enough of a natural blood-thinning protein, putting people at higher risk for dangerous blood clots that can affect the legs, lungs, and other organs.

  • 2

    Acquired ATTR amyloidosis

    Acquired ATTR amyloidosis, also known as wild-type ATTR, is a protein disorder that develops with age and affects the heart and nervous system. Unlike hereditary forms, it is not passed down through families but occurs when normal transthyretin proteins produced by the liver become unstable, misfold, and form harmful deposits in the body’s organs.

  • 0

    Acquired haemophilia

    Acquired haemophilia is a rare but potentially life-threatening bleeding disorder that can appear suddenly in people who have never had bleeding problems before. Unlike the inherited form of haemophilia, this condition develops when the body’s immune system mistakenly attacks its own clotting factors.

  • 4

    Acromegaly

    Acromegaly is a rare hormonal condition that develops when the body produces too much growth hormone, causing bones, organs, and tissues to grow in unusual ways. While the changes happen slowly over many years and can be difficult to notice at first, early diagnosis and proper treatment can help people with this condition live normal, healthy lives.

  • 1

    Actinic cheilitis

    Actinic cheilitis is a precancerous condition affecting the lips, caused by years of sun exposure that creates rough, scaly patches — particularly on the lower lip. Without proper treatment and protection, this condition can transform into a serious form of skin cancer.

  • 10

    Actinic keratosis

    Actinic keratosis is a rough, scaly patch on sun-exposed skin that develops from years of ultraviolet exposure. While most patches are harmless, they represent precancerous changes that can potentially develop into skin cancer, making early detection and treatment important for your skin health.

  • 2

    Activated PI3 kinase delta syndrome

    Activated PI3 kinase delta syndrome is a rare inherited immune disorder that leaves people vulnerable to repeated infections and other serious health problems. First identified in 2013, this condition affects the immune system’s ability to fight bacteria and viruses, often leading to a complex pattern of symptoms that can vary widely from one person to another.

  • 0

    Acute cardiac event

    When your heart suddenly stops getting enough blood, every minute counts. Understanding what happens during an acute cardiac event and knowing how to respond can make the difference between life and death.

  • 16

    Acute coronary syndrome

    Acute coronary syndrome is a life-threatening emergency that occurs when blood flow to the heart suddenly decreases or stops completely. This umbrella term includes heart attacks and unstable angina, all of which require immediate medical attention to prevent permanent heart damage or death.

  • 8

    Acute graft versus host disease

    Acute graft versus host disease is a serious complication that can occur after a stem cell transplant, when the donated immune cells mistake the recipient’s body as a threat and begin to attack it. This condition typically appears within the first three months after transplant and affects thousands of patients each year.

  • 3

    Acute graft versus host disease in intestine

    Acute graft versus host disease affecting the intestine is a serious complication that can occur after receiving donated stem cells, where the donor’s immune cells attack the recipient’s digestive system, causing severe symptoms and requiring careful management.

  • 1

    Acute graft versus host disease in liver

    Acute graft versus host disease of the liver is a serious complication that can occur after a stem cell or bone marrow transplant, when donor immune cells attack the recipient’s liver tissue, typically within the first 100 days after transplantation.

  • 3

    Acute graft versus host disease in skin

    Acute graft versus host disease in skin is one of the most common complications after a bone marrow or stem cell transplant, where the donor’s immune cells mistakenly attack the recipient’s skin, often appearing as the first sign that something is wrong.

  • 1

    Acute haemorrhagic ulcerative colitis

    Acute haemorrhagic ulcerative colitis is a severe form of inflammatory bowel disease that causes bloody diarrhea, severe abdominal pain, and dangerous complications. Understanding this medical emergency can help patients recognize when urgent care is needed and what treatment options are available.

  • 0

    Acute hepatic failure

    Acute hepatic failure is a rare but life-threatening condition where the liver rapidly loses its ability to function within days or weeks, leading to serious complications that can affect the entire body.

  • 1

    Acute HIV infection

    Acute HIV infection is the earliest and most critical stage of HIV, typically developing within 2 to 4 weeks after the virus enters your body. During this period, the virus multiplies rapidly and spreads throughout your system, often causing flu-like symptoms that can easily be mistaken for other common illnesses.

  • 18

    Acute kidney injury

    Acute kidney injury is a sudden loss of kidney function that can happen within hours or days. While this condition can be serious and even life-threatening without treatment, many people recover fully when the underlying cause is found and treated quickly.

  • 2

    Acute leukaemia

    Acute leukaemia is an aggressive cancer of the blood and bone marrow that develops quickly and requires immediate treatment. While it can be life-threatening, newer treatments are helping more people live longer, and in children with certain types, there is a good chance for a cure.

  • 8

    Acute lymphocytic leukaemia

    Acute lymphocytic leukemia is a fast-moving cancer of the blood and bone marrow that primarily affects white blood cells called lymphocytes. While it’s the most common cancer in children, adults can develop it too, and treatment approaches offer hope for many patients.

  • 2

    Acute lymphocytic leukaemia recurrent

    Relapsed acute lymphocytic leukemia refers to the return of this blood cancer after previous treatment. While most people with ALL initially go into remission, between 15 and 20 percent of children and about 60 percent of adults experience a relapse, requiring additional treatment approaches.

  • 47

    Acute myeloid leukaemia

    Acute myeloid leukaemia is a rapidly progressing blood cancer that affects the bone marrow, causing it to produce abnormal white blood cells that crowd out healthy blood cells, leading to serious complications if left untreated.

  • 1

    Acute myeloid leukaemia (in remission)

    Achieving remission in acute myeloid leukemia marks a crucial turning point in treatment, but it’s not the end of the journey. Understanding what remission means, what comes next, and how to care for yourself during this phase is essential for the best possible outcomes.

  • 3

    Acute myeloid leukaemia recurrent

    When acute myeloid leukemia returns after treatment or doesn’t respond to initial therapy, patients face a challenging situation that requires additional treatment approaches. Understanding what happens during recurrence and knowing the available treatment options can help patients navigate this difficult phase of their cancer journey.

  • 3

    Acute myeloid leukaemia refractory

    Refractory acute myeloid leukaemia is when the disease does not respond to initial treatment, a challenging situation that requires carefully tailored approaches to help patients achieve remission.

  • 20

    Acute myocardial infarction

    A heart attack is a medical emergency that happens when blood flow to part of the heart muscle suddenly stops, causing damage or death to heart cells. Every year, more than 800,000 people in the United States experience a heart attack, and time is critical—every minute without treatment means more heart tissue is at risk.

  • 3

    Acute on chronic liver failure

    Acute on chronic liver failure is a serious medical condition where the liver suddenly stops working properly in people who already have long-term liver disease. This sudden breakdown can happen quickly and affects not only the liver but also other vital organs in the body, making it a life-threatening emergency.

  • 2

    Acute promyelocytic leukaemia

    Acute promyelocytic leukaemia is a rare blood cancer that was once rapidly fatal but has been transformed into one of the most curable forms of leukaemia through revolutionary treatment advances.

  • 13

    Acute respiratory distress syndrome

    Acute respiratory distress syndrome (ARDS) is a life-threatening lung injury that causes fluid to build up in the tiny air sacs of your lungs, leading to dangerously low oxygen levels in your blood. This serious condition usually develops within hours to days after a major illness or injury, and requires immediate intensive care treatment.

  • 4

    Acute respiratory failure

    Acute respiratory failure is a life-threatening condition where your lungs cannot get enough oxygen into your blood or cannot remove enough carbon dioxide from your body. It happens suddenly and requires immediate medical attention.

  • 0

    Addison’s disease

    Addison’s disease is a rare but serious condition where your adrenal glands stop making enough vital hormones your body needs to function. Though it develops slowly and can be hard to spot at first, it’s manageable with daily medication and can allow you to live a normal life.

  • 1

    Adenocarcinoma

    Adenocarcinoma is a type of cancer that begins in the glands lining your organs. It can affect many parts of your body, from your lungs and breasts to your stomach and colon, making it one of the most common forms of cancer people face today.

  • 14

    Adenocarcinoma gastric

    Adenocarcinoma gastric is the most common form of stomach cancer, accounting for 90% to 95% of all stomach cancers. It develops in the cells that line the innermost layer of the stomach and often goes unnoticed in early stages, making it one of the leading causes of cancer death worldwide.

  • 4

    Adenocarcinoma of colon

    Adenocarcinoma is the most common type of colon cancer, starting in the glands that line the inside of your large intestine. While it typically affects older adults, early detection through screening and advances in treatment have improved outcomes for many patients.

  • 10

    Adenocarcinoma pancreas

    Adenocarcinoma of the pancreas is the most common type of pancreatic cancer, accounting for about 90% of cases. This disease often develops without early warning signs, making it difficult to detect until it has advanced. Understanding this cancer, its symptoms, and available treatments can help patients and their families navigate this challenging diagnosis.

  • 1

    Adenoid cystic carcinoma of salivary gland

    Adenoid cystic carcinoma of the salivary gland is a rare and slow-growing cancer that can be challenging to diagnose and treat. While it has a good survival rate in the first five years, this cancer has a strong tendency to return even many years after treatment, making long-term monitoring essential.

  • 0

    Adenomatous polyposis coli

    Adenomatous polyposis coli is a rare, inherited condition that causes hundreds to thousands of growths called polyps to develop in the large intestine, creating a nearly certain risk of cancer by middle age if left untreated.

  • 1

    Adenomyosis

    Adenomyosis is a condition where tissue that normally lines the inside of the uterus grows into the muscular wall of the uterus, causing symptoms like heavy periods, severe cramping, and pelvic pain that can significantly affect daily life.

  • 3

    Adenosquamous cell lung cancer

    Adenosquamous cell lung cancer is a rare and aggressive type of lung cancer that contains characteristics of both lung adenocarcinoma and squamous cell carcinoma. This uncommon cancer accounts for only a small percentage of all lung cancer cases but requires specialized attention due to its unique features and treatment challenges.

  • 2

    Adenosquamous cell lung cancer recurrent

    Recurrent adenosquamous cell lung cancer is a rare and aggressive form of lung cancer that comes back after treatment. Understanding this disease and the treatment options available can help patients and their families navigate their journey toward better health outcomes.

  • 1

    Adenosquamous cell lung cancer stage 0

    Adenosquamous cell lung cancer stage 0 is a very early form of a rare lung cancer that combines features of two different cancer types, found only in the top lining of the lung before it has spread anywhere else.

  • 1

    Adenosquamous cell lung cancer stage I

    Adenosquamous carcinoma of the lung stage I is a rare and aggressive form of lung cancer that contains both glandular and squamous cell components. Though it represents only a small percentage of all lung cancers, early detection at stage I offers the best chance for successful treatment and long-term survival.

  • 1

    Adenosquamous cell lung cancer stage II

    Adenosquamous cell lung cancer stage II is a rare and complex form of lung cancer that contains features of two different cancer types. While it has started to spread beyond the original tumor, it is still considered treatable, with surgery and chemotherapy offering meaningful benefits to many patients.

  • 2

    Adenosquamous cell lung cancer stage III

    Stage III adenosquamous cell lung cancer is a rare and aggressive form of lung cancer that contains both adenocarcinoma and squamous cell carcinoma components. Though challenging to treat, advances in chemotherapy, targeted therapy, and immunotherapy offer hope for improving survival and quality of life.

  • 2

    Adenosquamous cell lung cancer stage IV

    Adenosquamous cell lung cancer stage IV is an advanced, rare form of lung cancer that has spread beyond its original location, presenting unique challenges for diagnosis and treatment. This disease combines features of two different cancer types and requires careful management to improve outcomes.

  • 3

    Adenovirus infection

    Adenoviruses are a group of common viruses that can cause infections ranging from mild cold-like symptoms to more serious illnesses, particularly in young children and people with weakened immune systems.

  • 1

    Adrenal insufficiency

    Adrenal insufficiency is a disorder where the adrenal glands cannot make enough of certain essential hormones that keep your body working properly. While this is a rare condition, with proper treatment most people can lead normal, active lives.

  • 4

    Adrenocortical carcinoma

    Adrenocortical carcinoma is a rare but aggressive cancer that develops in the outer layer of the adrenal glands, small organs that sit on top of your kidneys and produce vital hormones. Though it affects only about 1 or 2 people per million each year, this cancer can cause serious health problems by releasing excessive amounts of hormones or growing large enough to press on nearby organs.

  • 0

    Adrenogenital syndrome

    Adrenogenital syndrome, also known as congenital adrenal hyperplasia, is a group of genetic disorders that affects the adrenal glands and their ability to produce vital hormones your body needs to function properly.

  • 4

    Adrenoleukodystrophy

    Adrenoleukodystrophy is a rare genetic condition that causes serious damage to the nervous system and hormone-producing glands. This inherited disorder affects mainly males and can cause rapid loss of abilities in childhood, though some forms develop more slowly in adulthood.

  • 1

    Adult T-cell lymphoma/leukaemia

    Adult T-cell leukemia/lymphoma is a rare cancer linked to a virus that can remain silent for decades before causing serious disease in a small number of infected individuals.

  • 1

    Adult T-cell lymphoma/leukaemia recurrent

    Adult T-cell leukemia/lymphoma (ATLL) is a rare and aggressive blood cancer linked to a viral infection. When the disease returns after treatment or does not respond to initial therapy, patients face particularly challenging circumstances that require specialized approaches and careful consideration of available options.

  • 1

    Adult T-cell lymphoma/leukaemia refractory

    Adult T-cell lymphoma/leukaemia that stops responding to treatment poses one of the most challenging situations in blood cancer care, with patients facing limited options and urgent need for new therapeutic approaches.