Explore popular diseases in clinical trials

Check which popular diseases are currently being frequently studied.

See also our rare diseases glossary and drug database.

Starting by letter

To open the diseases glossary, select a letter from the list below.

Most popular diseases

The list below features the most popular diseases currently involved in ongoing clinical trials.

Disease Trials
Non-small cell lung cancer 238
Breast cancer 131
Neoplasm 124
Plasma cell myeloma 122
Acute myeloid leukaemia 102
Neoplasm malignant 91
Prostate cancer 89
Colitis ulcerative 87
Obesity 81
Colorectal cancer metastatic 80
Crohn’s disease 76
Dementia Alzheimer’s type 75
Ovarian cancer 71
Type 2 diabetes mellitus 71
Colorectal cancer 69
Dermatitis atopic 66
Malignant melanoma 65
Breast cancer metastatic 65
Hepatocellular carcinoma 63
Triple negative breast cancer 62
Chronic lymphocytic leukaemia 60
Asthma 60
Non-small cell lung cancer metastatic 59
Squamous cell carcinoma of head and neck 58
Rheumatoid arthritis 58
HIV infection 57
Hormone receptor positive HER2 negative breast cancer 55
Osteoarthritis 55
Renal transplant 50
Pancreatic carcinoma 49
Chronic kidney disease 49
Ischaemic stroke 45
Parkinson’s disease 44
Atrial fibrillation 44
Systemic lupus erythematosus 43
Multiple sclerosis 42
Gastric cancer 42
Oesophageal adenocarcinoma 40
Hormone-refractory prostate cancer 40
Bladder cancer 40
Chronic obstructive pulmonary disease 40
Psoriasis 40
Non-small cell lung cancer stage IV 40
Migraine 39
Major depression 38
Endometrial cancer 38
Psoriatic arthropathy 37
Overweight 36
Myelodysplastic syndrome 36
Glioblastoma 36
Transitional cell carcinoma 36
Cardiac failure 35
Diffuse large B-cell lymphoma 35
Hormone receptor positive breast cancer 33
Systemic scleroderma 33
Schizophrenia 32
Type 1 diabetes mellitus 32
COVID-19 32
Cholangiocarcinoma 32
Prostate cancer metastatic 31
Head and neck cancer 31
Hidradenitis 31
HER2 positive breast cancer 30
Adenocarcinoma pancreas 30
Myasthenia gravis 30
Cervix carcinoma 29
Coronary artery disease 29
Acute lymphocytic leukaemia 29
Renal cell carcinoma 29
Rectal cancer 29
Pulmonary arterial hypertension 28
Follicular lymphoma 28
Plasma cell myeloma refractory 28
Pancreatic carcinoma metastatic 27
Oesophageal carcinoma 27
Depression 27
Bladder transitional cell carcinoma 27
Adenocarcinoma gastric 26
Pneumonia 26
Procedural pain 25
Interstitial lung disease 25
Metastatic malignant melanoma 25
B-cell lymphoma 25
Acute myocardial infarction 25
Idiopathic pulmonary fibrosis 24
Myelofibrosis 24
Non-small cell lung cancer stage III 24
Colon cancer 24
Amyotrophic lateral sclerosis 24
Non-small cell lung cancer stage IIIB 24
Fallopian tube cancer 23
Small cell lung cancer 23
Breast cancer female 23
Sjogren’s syndrome 23
B-cell small lymphocytic lymphoma 22
Soft tissue sarcoma 22
Cardiac amyloidosis 22
Lung neoplasm malignant 22
Sepsis 22
Small cell lung cancer extensive stage 22

Diseases starting with e

  • 1

    Eructation

    Eructation, commonly known as belching or burping, is a natural way your body releases excess air from your digestive system through your mouth. While everyone experiences this occasionally, sometimes it becomes frequent enough to interfere with daily life and may signal an underlying health concern.

  • 1

    Erythema

    Erythema multiforme is a skin reaction that creates distinctive target-shaped marks on your body, usually triggered by infections or medications. While the rash can be uncomfortable and alarming, most cases resolve on their own within a few weeks.

  • 0

    Erythema migrans

    Erythema migrans is a distinctive expanding rash that appears in over 70 percent of people with Lyme disease, serving as the most recognizable early warning sign of this tick-borne infection.

  • 1

    Erythema multiforme

    Erythema multiforme is a skin condition that causes a distinctive rash that looks like a target or bulls-eye. It is usually triggered by an infection or, less commonly, by certain medications, and typically resolves on its own within a few weeks.

  • 2

    Escherichia infection

    Escherichia coli, or E. coli, is a type of bacteria that naturally lives in the digestive system of humans and animals. While most strains are harmless and even helpful, certain types can cause illnesses ranging from mild stomach upset to life-threatening complications.

  • 1

    Escherichia urinary tract infection

    Urinary tract infections caused by E. coli bacteria are among the most common infections people experience, affecting millions each year and often returning even after treatment.

  • 0

    Essential hypertension

    Essential hypertension is high blood pressure without a clear, single cause—a condition affecting millions of people worldwide. Though it often goes unnoticed for years, it can lead to serious health problems if left untreated. Understanding what it is and how to manage it can help protect your heart, brain, and kidneys.

  • 7

    Essential thrombocythaemia

    Essential thrombocythaemia is a rare blood disorder where your bone marrow produces too many platelets, leading to an increased risk of blood clots, heart attack, or stroke—yet with proper treatment, most people live a nearly normal life.

  • 16

    Ewing’s sarcoma

    Ewing’s sarcoma is a rare and aggressive cancer that most often affects children and teenagers, beginning as abnormal cell growth in bones or nearby soft tissues and requiring prompt treatment with chemotherapy, surgery, or radiation therapy.

  • 4

    Ewing’s sarcoma metastatic

    Metastatic Ewing’s sarcoma is a challenging condition in which cancer that began in bone or soft tissue has spread to distant parts of the body, most commonly the lungs, presenting unique treatment challenges and requiring aggressive therapy approaches.

  • 2

    Ewing’s sarcoma recurrent

    When Ewing’s sarcoma returns after treatment or does not respond to initial therapy, patients face a challenging situation with limited standard treatment options. Understanding what recurrence means and what approaches are available can help patients and families navigate this difficult journey.

  • 2

    Exfoliation glaucoma

    Exfoliation glaucoma is the most common identifiable form of secondary open-angle glaucoma worldwide, affecting an estimated 5 to 6 million people globally. This serious eye condition develops when abnormal protein material accumulates in the eye’s drainage system, leading to elevated pressure and potentially severe vision loss if left untreated.

  • 0

    Exposure via breast milk

    While breastfeeding provides vital nutrition and protection for babies, certain substances can pass from mother to infant through breast milk. Understanding what can be transmitted and how to minimize risks helps mothers make informed decisions about safely continuing to breastfeed.

  • 1

    External cephalic version

    External cephalic version is a procedure that can help turn a baby from a breech position to a head-down position before birth, potentially allowing for a vaginal delivery instead of a cesarean section.

  • 1

    Extra-osseous Ewing’s sarcoma

    Extra-osseous Ewing’s sarcoma is a rare and aggressive cancer that begins in the soft tissues around bones rather than in the bones themselves. While most Ewing sarcomas start in bones, this form affects muscles, tendons, ligaments, and sometimes even internal organs, requiring specialized diagnosis and treatment approaches.

  • 1

    Extra-osseous Ewing’s sarcoma metastatic

    Extra-osseous Ewing’s sarcoma metastatic is a rare and aggressive form of cancer that originates in soft tissues rather than bones and has spread to other parts of the body. This condition shows aggressive clinical behavior with high rates of distant spread, requiring a comprehensive treatment approach combining multiple therapies.

  • 1

    Extra-osseous Ewing’s sarcoma recurrent

    Extra-osseous Ewing’s sarcoma recurrent is a rare and aggressive cancer that returns after treatment, presenting significant challenges even with modern therapies and requiring individualized care approaches.

  • 4

    Extranodal marginal zone B-cell lymphoma (MALT type)

    Extranodal marginal zone B-cell lymphoma, commonly called MALT lymphoma, is a rare, slow-growing cancer that develops in the moist tissues lining organs and body cavities, most often in the stomach, lungs, or tissues around the eyes.

  • 0

    Extraskeletal myxoid chondrosarcoma

    Extraskeletal myxoid chondrosarcoma is a very rare type of cancer that develops in soft tissues rather than bones, affecting only about 14 people each year in England. Despite its slow growth, this tumor can come back or spread years after initial treatment, requiring long-term monitoring and careful management.

  • 1

    Extraskeletal ossification

    Extraskeletal ossification, also known as heterotopic ossification, is a condition where bone tissue grows in places where it normally shouldn’t be found—in soft tissues like muscles, tendons, or other connective tissue outside the skeleton.

  • 1

    Exudative retinopathy

    Exudative retinopathy refers to conditions where fluid leaks from damaged blood vessels in the retina, causing buildup beneath the light-sensitive tissue at the back of the eye. This fluid accumulation can lead to vision problems if left untreated, making early detection and proper management essential for protecting your sight.

  • 2

    Eye disorder

    Eye disorders affect millions of people worldwide, with over 2.2 billion experiencing some form of vision impairment or blindness, making them among the most common health conditions globally.

  • 2

    Eye inflammation

    Eye inflammation occurs when parts of the eye become swollen and irritated, causing symptoms like redness, pain, and vision problems. This common condition can affect anyone and may result from infections, immune system reactions, or injury, making early diagnosis and treatment essential to protect your sight.

  • 1

    Eye pain

    Eye pain can range from mild irritation to intense discomfort, affecting one or both eyes. While most cases resolve on their own or with simple treatments, some types of eye pain can signal serious underlying conditions that require immediate medical attention.

  • 1

    Eyelid ptosis

    When your upper eyelid droops down over your eye, this condition is known as eyelid ptosis. The drooping can range from barely noticeable to severe enough to completely cover your pupil and block your vision, affecting your ability to see clearly and perform daily activities.