Explore popular diseases in clinical trials

Check which popular diseases are currently being frequently studied.

See also our rare diseases glossary and drug database.

Starting by letter

To open the diseases glossary, select a letter from the list below.

Most popular diseases

The list below features the most popular diseases currently involved in ongoing clinical trials.

Disease trials
Non-small cell lung cancer 228
Breast cancer 94
Obesity 86
Prostate cancer 73
Colorectal cancer 69
Ovarian cancer 66
Non-small cell lung cancer metastatic 66
Crohn’s disease 61
Type 2 diabetes mellitus 54
Rheumatoid arthritis 54
Triple negative breast cancer 52
Hormone receptor positive HER2 negative breast cancer 52
Asthma 51
Acute myeloid leukaemia 50
Squamous cell carcinoma of head and neck 50
Chronic kidney disease 49
Neoplasm 48
Colorectal cancer metastatic 47
Hepatocellular carcinoma 47
Systemic lupus erythematosus 40
Colitis ulcerative 40
Multiple sclerosis 39
Overweight 39
Dementia Alzheimer’s type 39
Gastric cancer 38
Myelodysplastic syndrome 37
Parkinson’s disease 37
HER2 positive breast cancer 37
Glioblastoma 37
Atrial fibrillation 34
Bladder cancer 34
Chronic obstructive pulmonary disease 33
Ischaemic stroke 33
Prostate cancer metastatic 33
Myasthenia gravis 32
Renal transplant 31
Type 1 diabetes mellitus 31
Head and neck cancer 31
Endometrial cancer 31
Malignant melanoma 31
Non-small cell lung cancer stage IV 31
Diffuse large B-cell lymphoma 31
Breast cancer metastatic 31
HIV infection 30
Dermatitis atopic 28
Cholangiocarcinoma 28
Coronary artery disease 28
Plasma cell myeloma 28
Pulmonary arterial hypertension 28
Neoplasm malignant 27
Rectal cancer 27
Renal cell carcinoma 26
Pancreatic carcinoma 26
Schizophrenia 26
Duchenne muscular dystrophy 25
Non-small cell lung cancer stage III 25
Follicular lymphoma 25
COVID-19 25
Migraine 24
Hormone receptor positive breast cancer 24
Idiopathic pulmonary fibrosis 24
Non-small cell lung cancer stage IIIB 24
Sepsis 24
Chronic lymphocytic leukaemia 24
Soft tissue sarcoma 24
Mantle cell lymphoma 23
Small cell lung cancer extensive stage 23
Colon cancer 23
Fallopian tube cancer 23
Influenza 22
Small cell lung cancer 21
Interstitial lung disease 21
Acute myocardial infarction 21
Oesophageal adenocarcinoma 21
Amyotrophic lateral sclerosis 21
Chronic rhinosinusitis with nasal polyps 20
Cystic fibrosis 20
Glioma 20
Myelofibrosis 19
Neuroblastoma 19
B-cell lymphoma 19
Sickle cell disease 19
Major depression 19
Procedural pain 19
Axial spondyloarthritis 18
Osteoarthritis 18
Breast cancer female 17
Critical illness 17
Acute kidney injury 17
Hereditary angioedema 17
Relapsing-remitting multiple sclerosis 16
Acute coronary syndrome 16
IgA nephropathy 16
Psoriasis 16
Gastrooesophageal cancer 16
Ewing’s sarcoma 16
Cardiac failure 16
Vitiligo 16
Transitional cell carcinoma 15
Giant cell arteritis 15

Diseases starting with e

  • 0

    Eructation

    Eructation, commonly known as belching or burping, is a natural way your body releases excess air from your digestive system through your mouth. While everyone experiences this occasionally, sometimes it becomes frequent enough to interfere with daily life and may signal an underlying health concern.

  • 1

    Erythema

    Erythema multiforme is a skin reaction that creates distinctive target-shaped marks on your body, usually triggered by infections or medications. While the rash can be uncomfortable and alarming, most cases resolve on their own within a few weeks.

  • 1

    Erythema migrans

    Erythema migrans is a distinctive expanding rash that appears in over 70 percent of people with Lyme disease, serving as the most recognizable early warning sign of this tick-borne infection.

  • 1

    Erythema multiforme

    Erythema multiforme is a skin condition that causes a distinctive rash that looks like a target or bulls-eye. It is usually triggered by an infection or, less commonly, by certain medications, and typically resolves on its own within a few weeks.

  • 2

    Escherichia infection

    Escherichia coli, or E. coli, is a type of bacteria that naturally lives in the digestive system of humans and animals. While most strains are harmless and even helpful, certain types can cause illnesses ranging from mild stomach upset to life-threatening complications.

  • 1

    Escherichia urinary tract infection

    Urinary tract infections caused by E. coli bacteria are among the most common infections people experience, affecting millions each year and often returning even after treatment.

  • 1

    Essential hypertension

    Essential hypertension is high blood pressure without a clear, single cause—a condition affecting millions of people worldwide. Though it often goes unnoticed for years, it can lead to serious health problems if left untreated. Understanding what it is and how to manage it can help protect your heart, brain, and kidneys.

  • 4

    Essential thrombocythaemia

    Essential thrombocythaemia is a rare blood disorder where your bone marrow produces too many platelets, leading to an increased risk of blood clots, heart attack, or stroke—yet with proper treatment, most people live a nearly normal life.

  • 16

    Ewing’s sarcoma

    Ewing’s sarcoma is a rare and aggressive cancer that most often affects children and teenagers, beginning as abnormal cell growth in bones or nearby soft tissues and requiring prompt treatment with chemotherapy, surgery, or radiation therapy.

  • 4

    Ewing’s sarcoma metastatic

    Metastatic Ewing’s sarcoma is a challenging condition in which cancer that began in bone or soft tissue has spread to distant parts of the body, most commonly the lungs, presenting unique treatment challenges and requiring aggressive therapy approaches.

  • 2

    Ewing’s sarcoma recurrent

    When Ewing’s sarcoma returns after treatment or does not respond to initial therapy, patients face a challenging situation with limited standard treatment options. Understanding what recurrence means and what approaches are available can help patients and families navigate this difficult journey.

  • 0

    Exfoliation glaucoma

    Exfoliation glaucoma is the most common identifiable form of secondary open-angle glaucoma worldwide, affecting an estimated 5 to 6 million people globally. This serious eye condition develops when abnormal protein material accumulates in the eye’s drainage system, leading to elevated pressure and potentially severe vision loss if left untreated.

  • 0

    Exposure via breast milk

    While breastfeeding provides vital nutrition and protection for babies, certain substances can pass from mother to infant through breast milk. Understanding what can be transmitted and how to minimize risks helps mothers make informed decisions about safely continuing to breastfeed.

  • 1

    External cephalic version

    External cephalic version is a procedure that can help turn a baby from a breech position to a head-down position before birth, potentially allowing for a vaginal delivery instead of a cesarean section.

  • 1

    Extra-osseous Ewing’s sarcoma

    Extra-osseous Ewing’s sarcoma is a rare and aggressive cancer that begins in the soft tissues around bones rather than in the bones themselves. While most Ewing sarcomas start in bones, this form affects muscles, tendons, ligaments, and sometimes even internal organs, requiring specialized diagnosis and treatment approaches.

  • 1

    Extra-osseous Ewing’s sarcoma metastatic

    Extra-osseous Ewing’s sarcoma metastatic is a rare and aggressive form of cancer that originates in soft tissues rather than bones and has spread to other parts of the body. This condition shows aggressive clinical behavior with high rates of distant spread, requiring a comprehensive treatment approach combining multiple therapies.

  • 1

    Extra-osseous Ewing’s sarcoma recurrent

    Extra-osseous Ewing’s sarcoma recurrent is a rare and aggressive cancer that returns after treatment, presenting significant challenges even with modern therapies and requiring individualized care approaches.

  • 3

    Extranodal marginal zone B-cell lymphoma (MALT type)

    Extranodal marginal zone B-cell lymphoma, commonly called MALT lymphoma, is a rare, slow-growing cancer that develops in the moist tissues lining organs and body cavities, most often in the stomach, lungs, or tissues around the eyes.

  • 1

    Extraskeletal myxoid chondrosarcoma

    Extraskeletal myxoid chondrosarcoma is a very rare type of cancer that develops in soft tissues rather than bones, affecting only about 14 people each year in England. Despite its slow growth, this tumor can come back or spread years after initial treatment, requiring long-term monitoring and careful management.

  • 1

    Extraskeletal ossification

    Extraskeletal ossification, also known as heterotopic ossification, is a condition where bone tissue grows in places where it normally shouldn’t be found—in soft tissues like muscles, tendons, or other connective tissue outside the skeleton.

  • 0

    Exudative retinopathy

    Exudative retinopathy refers to conditions where fluid leaks from damaged blood vessels in the retina, causing buildup beneath the light-sensitive tissue at the back of the eye. This fluid accumulation can lead to vision problems if left untreated, making early detection and proper management essential for protecting your sight.

  • 2

    Eye disorder

    Eye disorders affect millions of people worldwide, with over 2.2 billion experiencing some form of vision impairment or blindness, making them among the most common health conditions globally.

  • 2

    Eye inflammation

    Eye inflammation occurs when parts of the eye become swollen and irritated, causing symptoms like redness, pain, and vision problems. This common condition can affect anyone and may result from infections, immune system reactions, or injury, making early diagnosis and treatment essential to protect your sight.

  • 1

    Eye pain

    Eye pain can range from mild irritation to intense discomfort, affecting one or both eyes. While most cases resolve on their own or with simple treatments, some types of eye pain can signal serious underlying conditions that require immediate medical attention.

  • 0

    Eyelid ptosis

    When your upper eyelid droops down over your eye, this condition is known as eyelid ptosis. The drooping can range from barely noticeable to severe enough to completely cover your pupil and block your vision, affecting your ability to see clearly and perform daily activities.