Explore popular diseases in clinical trials

Check which popular diseases are currently being frequently studied.

See also our rare diseases glossary and drug database.

Starting by letter

To open the diseases glossary, select a letter from the list below.

Most popular diseases

The list below features the most popular diseases currently involved in ongoing clinical trials.

Disease Trials
Non-small cell lung cancer 238
Breast cancer 131
Neoplasm 123
Plasma cell myeloma 122
Acute myeloid leukaemia 102
Neoplasm malignant 91
Prostate cancer 89
Colitis ulcerative 88
Obesity 82
Colorectal cancer metastatic 81
Crohn’s disease 75
Dementia Alzheimer’s type 75
Ovarian cancer 71
Type 2 diabetes mellitus 71
Colorectal cancer 69
Dermatitis atopic 66
Malignant melanoma 65
Breast cancer metastatic 65
Hepatocellular carcinoma 63
Triple negative breast cancer 62
Non-small cell lung cancer metastatic 60
Asthma 60
Chronic lymphocytic leukaemia 59
Squamous cell carcinoma of head and neck 58
Rheumatoid arthritis 58
HIV infection 57
Hormone receptor positive HER2 negative breast cancer 55
Osteoarthritis 55
Chronic kidney disease 50
Renal transplant 50
Pancreatic carcinoma 49
Ischaemic stroke 45
Parkinson’s disease 44
Atrial fibrillation 44
Systemic lupus erythematosus 43
Multiple sclerosis 42
Gastric cancer 42
Oesophageal adenocarcinoma 40
Hormone-refractory prostate cancer 40
Bladder cancer 40
Chronic obstructive pulmonary disease 40
Psoriasis 40
Non-small cell lung cancer stage IV 40
Migraine 39
Major depression 38
Endometrial cancer 38
Psoriatic arthropathy 37
Overweight 36
Myelodysplastic syndrome 36
Glioblastoma 36
Transitional cell carcinoma 36
Cardiac failure 35
Diffuse large B-cell lymphoma 35
Hormone receptor positive breast cancer 33
Systemic scleroderma 33
Schizophrenia 32
Type 1 diabetes mellitus 32
COVID-19 32
Cholangiocarcinoma 32
Prostate cancer metastatic 31
Head and neck cancer 31
Hidradenitis 31
HER2 positive breast cancer 30
Acute lymphocytic leukaemia 30
Adenocarcinoma pancreas 30
Cervix carcinoma 29
Coronary artery disease 29
Renal cell carcinoma 29
Rectal cancer 29
Myasthenia gravis 29
Pulmonary arterial hypertension 28
Follicular lymphoma 28
Plasma cell myeloma refractory 28
Pancreatic carcinoma metastatic 27
Oesophageal carcinoma 27
Depression 27
Bladder transitional cell carcinoma 27
Adenocarcinoma gastric 26
Pneumonia 26
Procedural pain 25
Interstitial lung disease 25
Metastatic malignant melanoma 25
B-cell lymphoma 25
Acute myocardial infarction 25
Idiopathic pulmonary fibrosis 24
Myelofibrosis 24
Non-small cell lung cancer stage III 24
Colon cancer 24
Amyotrophic lateral sclerosis 24
Non-small cell lung cancer stage IIIB 24
Fallopian tube cancer 23
Small cell lung cancer 23
Breast cancer female 23
Sjogren’s syndrome 23
Soft tissue sarcoma 22
Cardiac amyloidosis 22
Lung neoplasm malignant 22
Sepsis 22
Small cell lung cancer extensive stage 22
Endocrine ophthalmopathy 22

All Diseases

  • 1

    Venous thrombosis limb

    Venous thrombosis limb, commonly known as deep vein thrombosis or DVT, is a serious condition where a blood clot forms in the deep veins of your body, most often in your leg. Understanding the warning signs and risk factors can help you get the prompt treatment needed to prevent life-threatening complications.

  • 3

    Ventricular extrasystoles

    Ventricular extrasystoles are extra heartbeats that start in the lower chambers of the heart, disrupting the regular heart rhythm. While they are extremely common and usually harmless in healthy people, understanding when they need attention is important for your health.

  • 3

    Ventricular fibrillation

    Ventricular fibrillation is a life-threatening heart rhythm problem that causes your heart’s lower chambers to quiver instead of pumping blood. Without immediate treatment, this condition can lead to sudden cardiac death within minutes.

  • 4

    Ventricular tachycardia

    Ventricular tachycardia is a fast, abnormal heart rhythm that starts in the lower chambers of the heart and can become life-threatening if not properly managed, but with the right medical care and lifestyle adjustments, many people can live active, fulfilling lives.

  • 1

    Vertebrobasilar stroke

    Vertebrobasilar stroke is a serious medical condition where blood flow to the back of the brain suddenly stops or becomes blocked. Though less common than other stroke types, it causes a disproportionate amount of disability and death, often because its symptoms—like dizziness and nausea—can be mistaken for less serious conditions.

  • 1

    Vertigo

    Vertigo is a sensation of spinning or feeling that you or your surroundings are moving when you’re standing still. It’s not a disease itself, but rather a symptom of various conditions affecting your inner ear or brain, with a lifetime prevalence of around 20% to 30%.

  • 1

    Vesicoureteric reflux

    Vesicoureteric reflux is a condition where urine flows backward from the bladder toward the kidneys, most commonly affecting infants and young children. While many children outgrow this condition without lasting harm, understanding its causes, symptoms, and treatment options helps parents and caregivers protect their child’s kidney health.

  • 3

    Vestibular disorder

    Vestibular disorders affect millions of people worldwide, disrupting the delicate balance system that allows us to move confidently through daily life. These conditions can transform simple activities like grocery shopping or walking into challenging obstacles, leaving many feeling dizzy, unsteady, and struggling to maintain their quality of life.

  • 4

    VEXAS syndrome

    VEXAS syndrome is a rare and serious condition that causes the immune system to attack the body by mistake, leading to widespread inflammation and blood problems. Discovered only in 2020, this condition primarily affects men over 50 and is caused by a genetic mutation that happens during life, not one inherited from parents.

  • 3

    Viral infection

    Viral infections are illnesses caused by tiny organisms called viruses that invade your body’s cells to make copies of themselves. From the common cold to more serious conditions like the flu or COVID-19, these infections affect millions of people worldwide and can range from mild to life-threatening.

  • 2

    Viral myocarditis

    Viral myocarditis is an inflammation of the heart muscle caused by viral infections. While it can affect anyone, this condition most commonly strikes otherwise healthy young adults and can range from mild cases with no symptoms to severe complications that require urgent medical attention.

  • 4

    Vitamin D deficiency

    Vitamin D deficiency is a widespread condition affecting approximately 1 billion people worldwide, causing issues primarily with bones and muscles, yet many people don’t realize they have it because symptoms can be subtle or absent.

  • 16

    Vitiligo

    Vitiligo is a skin condition that causes patches of skin to lose their color, creating smooth white or light areas on the body. Affecting about 1% of people worldwide, this chronic condition is not harmful to physical health but can significantly impact how people feel about their appearance.

  • 1

    Vomiting

    Vomiting is a forceful expulsion of your stomach’s contents through your mouth. While often uncomfortable and distressing, it’s usually your body’s way of protecting itself by removing harmful substances. Understanding what causes vomiting and how to manage it can help you feel better faster.

  • 3

    Von Hippel-Lindau disease

    Von Hippel-Lindau disease is a rare genetic disorder that causes tumors and cysts to develop in multiple organs throughout a person’s life, requiring lifelong monitoring and often multiple surgeries, but new treatments are bringing hope to patients who once faced a lifetime of repeated operations.

  • 4

    Von Willebrand’s disease

    Von Willebrand’s disease is a lifelong bleeding condition that affects how blood clots, making it harder for bleeding to stop. While there is no cure, most people with this condition can lead active lives with proper care and treatment.

  • 5

    Vulval cancer

    Vulval cancer is a rare cancer that begins in the external female sex organs, most commonly appearing as a lump or sore that causes itching. While it can occur at any age, it is usually diagnosed in older adults, with most cases found in women over 50.

  • 0

    Vulval cancer recurrent

    Recurrent vulvar cancer means that the cancer has returned after treatment. This happens in approximately 24% of cases after initial treatment with surgery, with or without radiation.

  • 1

    Vulvar dysplasia

    Vulvar dysplasia involves abnormal changes in the skin cells of the vulva that can develop into cancer over time if left untreated, but with proper care and monitoring, most cases can be successfully managed before they ever become cancerous.

  • 1

    Vulvar squamous cell hyperplasia

    Vulvar squamous cell hyperplasia is a skin condition of the vulva that develops when chronic rubbing and scratching cause the skin to thicken abnormally. This condition, which creates a cycle of itching and scratching, can significantly affect a woman’s daily comfort and quality of life.

  • 2

    Vulvovaginal candidiasis

    Vulvovaginal candidiasis is a common fungal infection affecting the vagina and vulva, causing discomfort through itching, burning, and abnormal discharge. While not life-threatening, it affects three out of four women at least once in their lifetime.

  • 1

    Vulvovaginal discomfort

    Vulvovaginal discomfort is a widespread condition affecting women of all ages, characterized by pain, burning, itching, or irritation in the external and internal genital areas. While the causes range from infections to chronic pain conditions, many women experience significant relief through proper diagnosis and treatment.

  • 1

    Vulvovaginal dryness

    Vulvovaginal dryness is a common condition that can affect women at any age, though it becomes especially prevalent during and after menopause, impacting more than half of postmenopausal women and causing discomfort that extends far beyond the bedroom.

  • 1

    Vulvovaginal pain

    Vulvovaginal pain is a chronic condition that affects thousands of women worldwide, often lasting for months or years without a clear cause. This persistent discomfort can significantly impact daily activities, relationships, and quality of life, yet many women struggle to receive an accurate diagnosis and effective treatment.

  • 1

    Vulvovaginal pruritus

    Vulvovaginal pruritus, or itching in the vulva and vagina, is a common symptom that affects many women and can significantly impact quality of life, interfering with sleep, relationships, and daily activities.

  • 10

    Waldenstrom’s macroglobulinaemia

    Waldenstrom’s macroglobulinaemia is a rare, slow-growing blood cancer that affects white blood cells and causes production of an abnormal protein that can thicken the blood, making it harder to flow through blood vessels.

  • 2

    Waldenstrom’s macroglobulinaemia recurrent

    Waldenstrom’s macroglobulinaemia is a rare blood cancer that cannot be completely cured, which means that after successful treatment, the disease will eventually return. Understanding what happens when the cancer comes back and knowing your treatment options can help you manage this condition effectively.

  • 4

    Waldenstrom’s macroglobulinaemia refractory

    When Waldenstrom’s macroglobulinemia comes back after treatment or stops responding to therapy, patients and their healthcare teams face new decisions about the best path forward.

  • 3

    Warm autoimmune haemolytic anaemia

    Warm autoimmune haemolytic anaemia is a rare condition where the body’s immune system mistakenly attacks and destroys its own red blood cells, leading to profound fatigue and other serious symptoms that can severely impact daily life.

  • 2

    Weaning failure

    Between 20% and 30% of patients requiring mechanical ventilation face significant challenges when doctors try to remove their breathing support, a condition known as weaning failure. Understanding why this happens and how to address it can make a crucial difference in recovery.

  • 5

    Wheezing

    Wheezing is a high-pitched whistling or rattling sound you hear when breathing, usually when air struggles to pass through narrowed or partially blocked airways. It can be a temporary reaction to a cold or allergies, or it may signal a more serious health condition that requires medical attention.

  • 2

    White matter lesion

    White matter lesions appear as bright spots on brain scans and signal areas where the brain’s communication pathways have been damaged. While some lesions are a normal part of aging and cause no symptoms, others can lead to memory problems, balance difficulties, and changes in mood.

  • 2

    Wiskott-Aldrich syndrome

    Wiskott-Aldrich syndrome is a rare genetic condition that disrupts the immune system, causes dangerous bleeding problems, and leads to persistent eczema. Without proper treatment, this inherited disorder can become life-threatening, but modern medical advances offer hope through stem cell transplantation and gene therapy.

  • 2

    Wolfram syndrome

    Wolfram syndrome is a rare genetic condition that damages multiple body systems over time, usually beginning with diabetes and vision problems in childhood and progressing to affect the brain and other organs.

  • 1

    X-linked lymphoproliferative syndrome

    X-linked lymphoproliferative syndrome is a rare genetic disorder that affects how the immune system responds to infections, particularly the Epstein-Barr virus. This condition primarily affects males and can lead to serious, life-threatening complications if left untreated.

  • 0

    Yellow fever

    Yellow fever is a potentially deadly viral disease spread by mosquitoes in tropical regions of Africa and South America, causing symptoms ranging from fever and body aches to severe liver damage and bleeding, but it can be prevented with a single dose of vaccine that provides lifelong protection.