Idiopathic inflammatory myopathy is a group of rare autoimmune diseases that cause chronic muscle inflammation and weakness, often affecting daily activities like climbing stairs or lifting objects, while also potentially impacting other organs including the skin, lungs, and heart.

Idiopathic pulmonary fibrosis is a serious lung disease where tissue surrounding the air sacs becomes thick, stiff, and scarred for reasons that remain unknown. This progressive condition makes breathing increasingly difficult over time, affecting mostly people in their 60s and 70s.

IgA nephropathy is a kidney disease where a specific protein builds up in the kidneys, causing inflammation and damage over time. While it often progresses slowly and may go unnoticed for years, it is one of the most common kidney diseases worldwide and can eventually lead to kidney failure if not properly managed.

Congenital immunodeficiency disorders are a group of inherited conditions where the immune system doesn’t work properly from birth, making it harder for the body to fight off infections and other health challenges.

Inclusion body myositis is a slowly progressive muscle disease that most commonly affects people over 45, causing gradual weakness in the limbs and fingers. While there is currently no cure, understanding this condition and staying active can help maintain quality of life.

Indolent systemic mastocytosis is the most common form of a rare chronic disorder where abnormal mast cells build up in the body, mainly in the bone marrow and skin, causing symptoms that can range from mild to severely debilitating.

Isodicentric chromosome 15 syndrome is a rare genetic condition caused by extra genetic material from chromosome 15, leading to challenges with development, learning, and sometimes seizures.