Ongoing Clinical Trials for Traumatic Pain
This article provides information about ongoing clinical trials investigating treatments for traumatic pain. Currently, there is 1 active clinical trial exploring pain relief options for patients experiencing acute pain following injury. The trial is taking place in the Netherlands and is comparing different methods of administering pain-relief medications in emergency settings before patients reach the hospital.
Clinical trial locations
Study on Fentanyl and Esketamine for Pain Relief in Patients with Acute Traumatic Pain
This trial is examining how to best manage sudden, severe pain that occurs immediately after an injury. The study is comparing different ways of delivering pain-relief medications in emergency situations, such as in an ambulance, before patients arrive at the hospital.
Main inclusion criteria:
- Participants must be at least 18 years old
- Must have pain caused by an injury that happened on the same day
- Must need a strong painkiller, as determined by emergency medical staff
- Must be on the way to a hospital for treatment
Main exclusion criteria:
- Allergies to any of the medications being studied
- Pregnancy or breastfeeding
- History of substance abuse (problems with drugs or alcohol)
- Severe liver or kidney disease
- Uncontrolled high blood pressure
- Severe heart problems
- Recent head injury
- Current use of certain medications that might interfere with the study
- Mental health conditions that might affect the ability to understand the study
Focus and goal of the trial:
The main purpose of this study is to determine whether giving pain medication through the nose (intranasal) or directly into the bloodstream (intravenous) works equally well in emergency settings. Researchers want to find out if intranasal fentanyl, intravenous esketamine, and intranasal esketamine are as effective as intravenous fentanyl in relieving pain before patients reach the hospital.
Participants will receive one of these treatment options, and their pain levels will be monitored at several points: 10 minutes after receiving the medication, 20 minutes after the first dose, and when they arrive at the hospital. The study will also track whether additional doses are needed and any side effects that occur.
Investigational drugs:
Fentanyl is a strong pain-relief medication commonly used in emergency situations to manage severe pain. In this trial, it is being tested in a form that can be sprayed into the nose, allowing it to work quickly. The goal is to see if this nasal spray method is as effective as giving the medication through an IV.
Esketamine is the other medication being tested. It is known for its fast-acting pain-relief effects. The trial is studying two forms: one given through an IV and another sprayed into the nose. Researchers are comparing esketamine to fentanyl to see if it can provide similar pain relief in emergency situations.
The trial began recruiting participants in September 2023 and is expected to conclude by March 2025.
Summary
Currently, there is one ongoing clinical trial focused on improving pain management for individuals experiencing acute pain following trauma. This trial is being conducted in the Netherlands and is comparing different methods of administering pain-relief medications in prehospital emergency settings.
The study is investigating both fentanyl and esketamine, exploring whether administering these medications through the nose can be as effective as traditional intravenous methods. This research has the potential to improve emergency pain management by identifying faster and more practical ways to deliver effective pain relief to patients before they reach the hospital.
Patients interested in participating should be aware of the specific eligibility criteria, particularly the exclusion of those with certain medical conditions, allergies, or recent head injuries. The trial offers an opportunity to contribute to research that may improve emergency pain treatment for future patients experiencing similar injuries.
