This clinical trial is focused on studying the effects of a treatment for knee osteoarthritis, a condition that causes pain and stiffness in the knee joint. The treatment being tested is called Genicular Arteries Embolization (GAE), which involves using a special mixture of substances, including ioversol and ethyl esters of iodised fatty acids from poppyseed oil, to reduce blood flow to certain areas of the knee. This is done in the hope of reducing pain and improving knee function. The study will compare the effects of this treatment to a sham procedure, which is a fake treatment that looks like the real one but does not have any active ingredients.
The purpose of the study is to assess the effectiveness of GAE in reducing knee pain over a period of three months. Participants will receive either the GAE treatment or the sham procedure, and their pain levels will be monitored and compared. The study will also look at other aspects of knee health and overall well-being over a longer period, up to 12 months. This will help researchers understand if the treatment has lasting benefits and how it affects the quality of life for people with knee osteoarthritis.
Throughout the study, participants will have regular check-ups to monitor their progress and any changes in their condition. The study aims to provide valuable information on whether this new treatment can offer relief for those suffering from knee osteoarthritis, potentially leading to new options for managing this common and often painful condition.
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