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Ethyl Esters Of Iodised Fatty Acids From Poppyseed Oil

This article examines several clinical trials investigating the use of ethyl esters of iodised fatty acids from poppyseed oil, commonly known as Lipiodol, in various medical conditions. These trials explore its potential benefits in treating knee osteoarthritis, infertility, liver cancer, and as a contrast agent in medical imaging procedures. The studies aim to evaluate the efficacy, safety, and optimal dosing of this compound in different clinical settings.

Table of Contents

What is ETHYL ESTERS OF IODISED FATTY ACIDS FROM POPPYSEED OIL?

ETHYL ESTERS OF IODISED FATTY ACIDS FROM POPPYSEED OIL is a medical product derived from poppyseed oil. It’s also known by its brand name Lipiodol Ultra Fluide[1]. This substance is an iodine-containing contrast medium, which means it’s used to make certain body structures more visible during imaging procedures[2].

Medical Uses

This medication has several important medical applications:

  • Diagnostic Imaging: It’s used in various imaging procedures to help doctors see certain body structures more clearly[1].
  • Infertility Treatment: It’s being studied for its potential to improve fertility in women with at least one open fallopian tube[3].
  • Cancer Treatment: It’s used in the treatment of certain types of liver cancer, specifically hepatocellular carcinoma (HCC)[4].
  • Osteoarthritis Treatment: It’s being investigated for use in treating knee osteoarthritis[5].

How It Works

The way this medication works depends on its specific use:

  • As a Contrast Agent: When used in imaging, it helps make certain body structures more visible on X-rays or other imaging tests[2].
  • In Fertility Treatments: When used in a procedure called hysterosalpingography (HSG), it may help clear blockages in the fallopian tubes, potentially improving fertility[3].
  • In Cancer Treatment: When used in a procedure called transarterial chemoembolization (TACE), it helps deliver chemotherapy drugs directly to liver tumors while also blocking their blood supply[4].

How It’s Administered

The method of administration varies depending on its use:

  • Intrauterine Use: For fertility treatments, it’s injected into the uterus during a hysterosalpingography procedure[3].
  • Intraarterial Use: For liver cancer treatment, it’s injected into the arteries that supply blood to the tumor[4].
  • Injection: For knee osteoarthritis treatment, it’s injected directly into the knee joint[5].

Current Clinical Trials

Several clinical trials are currently investigating the use of this medication:

  • LIPIOJOINT-2 Trial: This study is examining its effectiveness in treating knee osteoarthritis through a procedure called Genicular Arteries Embolization (GAE)[5].
  • H2Oil-2 Study: This trial is comparing oil-based (using this medication) and water-based contrast media for hysterosalpingography in infertile women[3].
  • TACE-3 Trial: This study is investigating its use in combination with other treatments for intermediate-stage liver cancer[4].

Potential Side Effects and Precautions

As with any medication, there are potential side effects and precautions to be aware of:

  • Allergic Reactions: Some people may be allergic to iodine or poppy seed oil[1].
  • Thyroid Function: Due to its iodine content, it may affect thyroid function. Patients with thyroid disorders should inform their doctor[3].
  • Pregnancy and Breastfeeding: It should not be used in pregnant or breastfeeding women unless absolutely necessary[4].
  • Other Precautions: It may not be suitable for people with certain conditions such as severe kidney or liver problems, or certain heart conditions[5].

Conclusion

ETHYL ESTERS OF IODISED FATTY ACIDS FROM POPPYSEED OIL is a versatile medical product with applications in diagnostic imaging, fertility treatments, and cancer therapy. While it shows promise in various areas, it’s important to remember that many of its uses are still being studied in clinical trials. As with any medical treatment, it should only be used under the guidance of a healthcare professional who can weigh its potential benefits against any risks for your specific situation.

Trial Name Medical Condition Primary Objective Lipiodol Use
LIPIOJOINT-2 Knee Osteoarthritis Assess efficacy of Genicular Arteries Embolization using Lipiodol on knee pain As part of embolization procedure
H2Oil-2 Study Female Infertility Compare oil-based (Lipiodol) vs water-based contrast for hysterosalpingography As contrast agent for imaging
TACE-3 Intermediate Stage Hepatocellular Carcinoma Evaluate efficacy of nivolumab combined with TACE/TAE using Lipiodol As part of chemoembolization treatment
Idarubicin/Lipiodol Emulsion Study Hepatocellular Carcinoma on Cirrhosis Assess disease control rate after chemo-lipiodol treatment Combined with chemotherapy for liver cancer treatment

FAQ

  • What is Lipiodol and how is it used in these clinical trials? Lipiodol is a solution containing ethyl esters of iodised fatty acids from poppyseed oil. In these trials, it is used for various purposes, including as a contrast agent for imaging procedures, in embolization treatments for liver cancer, and in fertility treatments.
  • What medical conditions are being studied using Lipiodol in these trials? The clinical trials are investigating the use of Lipiodol in knee osteoarthritis, infertility in women, hepatocellular carcinoma (liver cancer), and as a contrast agent in hysterosalpingography for fertility evaluation.
  • How is Lipiodol being used in the treatment of knee osteoarthritis? In the LIPIOJOINT-2 trial, Lipiodol is being used as part of a procedure called Genicular Arteries Embolization (GAE) to treat symptomatic knee osteoarthritis. The study aims to assess the efficacy of this treatment in reducing knee pain.
  • What is the role of Lipiodol in fertility treatments? Lipiodol is being studied in fertility treatments as a contrast agent for hysterosalpingography (HSG) and as a potential treatment to improve pregnancy rates. Some trials are comparing oil-based contrast (Lipiodol) to water-based contrast in HSG procedures.
  • How is Lipiodol being used in liver cancer treatment? In liver cancer trials, Lipiodol is being used as part of a treatment called transarterial chemoembolization (TACE). It is combined with chemotherapy drugs and injected into the liver arteries to treat hepatocellular carcinoma.

Ongoing Clinical Trials on Ethyl Esters Of Iodised Fatty Acids From Poppyseed Oil

  • Study Comparing Oil-Based and Water-Based Contrast Media for Infertility in Women: Iodixanol and Ethyl Esters of Iodised Fatty Acids from Poppyseed Oil

    Recruiting

    3 1 1 1
    Investigated drugs:
    The Netherlands

  • Study on Liver Cancer in Cirrhosis Patients Using Idarubicin and Lipiodol Injection

    Recruiting

    2 1 1 1
    Investigated diseases:
    Investigated drugs:
    France

  • Study on the Effect of Genicular Arteries Embolization with Ioversol and Ethyl Esters of Iodised Fatty Acids in Patients with Symptomatic Knee Osteoarthritis

    Recruiting

    3 1 1 1
    Investigated drugs:
    France

  • Study on Nivolumab with Drug Combination for Patients with Intermediate Stage Liver Cancer

    Not recruiting

    4 1 1 1
    Investigated diseases:
    Investigated drugs:
    France

  • Study on the Effect of Oil-Based Tubal Flushing with Ethyl Esters of Iodised Fatty Acids on Pregnancy in Infertile Women with One Open Fallopian Tube

    Not recruiting

    3 1 1 1
    Investigated diseases:
    Investigated drugs:
    Belgium

Glossary

  • Ethyl Esters of Iodised Fatty Acids from Poppyseed Oil: Also known as Lipiodol, this is an iodine-containing contrast agent used in various medical procedures and treatments. It is derived from poppyseed oil and contains iodine, making it visible on X-rays and other imaging techniques.
  • Hysterosalpingography (HSG): A medical imaging procedure used to examine the uterus and fallopian tubes. It involves injecting a contrast medium (like Lipiodol) into the uterus and taking X-ray images to assess fertility issues.
  • Genicular Arteries Embolization (GAE): A minimally invasive procedure used to treat knee osteoarthritis by blocking small arteries around the knee joint, potentially reducing inflammation and pain.
  • Transarterial Chemoembolization (TACE): A cancer treatment procedure that combines embolization (blocking blood supply) with local delivery of chemotherapy drugs to treat liver tumors.
  • Hepatocellular Carcinoma (HCC): The most common type of primary liver cancer, usually occurring in people with chronic liver diseases such as cirrhosis.
  • mRECIST Criteria: Modified Response Evaluation Criteria in Solid Tumors, a set of rules used to assess the response of solid tumors to treatment in cancer clinical trials.
  • Child-Pugh Score: A scoring system used to assess the prognosis of chronic liver disease, mainly cirrhosis. It classifies liver function into classes A, B, and C, with A being the best liver function.
  • BCLC Staging: Barcelona Clinic Liver Cancer staging, a system used to stage liver cancer and guide treatment decisions.
  • ECOG Performance Status: Eastern Cooperative Oncology Group performance status, a scale used to assess how a patient's disease is progressing and how it affects daily living abilities.
  • Tubal Patency: The condition of fallopian tubes being open and unobstructed, allowing eggs to travel from the ovaries to the uterus.

References

  1. http://clinicaltrials.eu/trial/study-on-the-effect-of-genicular-arteries-embolization-with-ioversol-and-ethyl-esters-of-iodised-fatty-acids-in-patients-with-symptomatic-knee-osteoarthritis/
  2. http://clinicaltrials.eu/trial/study-on-the-effect-of-oil-based-tubal-flushing-with-ethyl-esters-of-iodised-fatty-acids-on-pregnancy-in-infertile-women-with-one-open-fallopian-tube/
  3. http://clinicaltrials.eu/trial/study-comparing-oil-based-and-water-based-contrast-media-for-infertility-in-women-iodixanol-and-ethyl-esters-of-iodised-fatty-acids-from-poppyseed-oil/
  4. http://clinicaltrials.eu/trial/study-on-nivolumab-with-drug-combination-for-patients-with-intermediate-stage-liver-cancer/
  5. http://clinicaltrials.eu/trial/study-on-liver-cancer-in-cirrhosis-patients-using-idarubicin-and-lipiodol-injection/