This study looks at muscle protein turnover in people who receive hemodialysis, which is a treatment that filters waste and extra fluid from the blood when the kidneys can no longer do this job properly. Patients who need hemodialysis often have problems maintaining their muscle mass, which can affect their strength and overall health. The study will use a treatment called intradialytic parenteral nutrition, which means giving liquid nutrition directly into the bloodstream during the dialysis session. This nutrition solution contains various amino acids, which are the building blocks of proteins, along with glucose for energy and minerals like calcium, magnesium, and potassium that the body needs to function properly.
The purpose of the study is to see how this nutrition given during dialysis affects the way muscles build new proteins and to understand how it affects blood pressure and heart function during the dialysis treatment. The study will compare periods when patients receive the nutrition solution during dialysis with periods when they do not receive it. During the study, researchers will measure how quickly the muscles make new proteins and will track the levels of amino acids in the blood and in the fluid removed during dialysis. They will also monitor blood pressure and how well the heart is pumping blood throughout the treatment sessions.
Participants will undergo dialysis sessions three times per week as they normally would, but during some weeks they will receive the additional nutrition through their dialysis access point. The study will involve taking blood samples and measuring various aspects of muscle and heart function. The research will last for several weeks for each participant, allowing researchers to compare the effects of receiving nutrition during dialysis versus not receiving it. This information will help doctors understand whether giving nutrition during dialysis can help hemodialysis patients maintain or improve their muscle health.
The Netherlands 