Table of Contents
- Overview of the clinical research
- Who the trials are for
- Trial design and phase
- What the trials measure
- Main trial summary
Overview of the clinical research
The clinical trial data provided includes one study that investigates Amiloride Hydrochloride in people with uncontrolled hypertension and moderate to severe chronic kidney disease.[1]
This study is designed to test whether a diuretic-based treatment approach can improve important health outcomes, including kidney disease progression, heart and blood vessel events, and death.[1]
Who the trials are for
The target population is adults with uncontrolled hypertension, which means high blood pressure that is not well controlled, together with moderate to severe chronic kidney disease.[1]
The trial is not described as being for a general population. It is focused on people with both blood pressure problems and significant kidney disease.[1]
Trial design and phase
The study is a Phase 3 interventional trial, which means researchers are testing a treatment strategy in a larger group of participants to learn more about how well it works.[1]
The planned enrollment is 720 participants, showing that the study is designed to collect results from a substantial number of people.[1]
The brief summary says the study is evaluating an algorithm based on diuretic agents, and Amiloride Hydrochloride is one of the study drugs listed in the trial record.[1]
What the trials measure
The main outcome is a composite endpoint, which is a combined measure of several serious health events.[1]
The endpoint includes end-stage kidney disease, meaning kidney failure that may require kidney replacement therapy or kidney transplantation, a decline in kidney function measured by eGFR, cardiovascular events, and all-cause mortality.[1]
The trial summary says the goal is to reduce the incidence of these outcomes and slow chronic kidney disease progression.[1]
Main trial summary
The key study in the provided data is trial NCT05732727, which is an authorised Phase 3 trial in people with uncontrolled hypertension and moderate to severe chronic kidney disease.[1]
It includes Amiloride Hydrochloride as one of several diuretic treatment options and focuses on long-term kidney, heart, and survival outcomes.[1]
No other Amiloride Hydrochloride trial records were provided in the source data, so this overview is based on the single available study.[1]
