Duloxetine is a medication often used to treat depression and anxiety. In this trial, it is being tested to see if it can help control muscle and joint pain, such as arthralgias, myalgias, and bone pain, which are related to endocrine therapy in patients with early breast cancer.

Furosemide is a medication commonly used to reduce fluid retention and swelling caused by various medical conditions. In this trial, it is being evaluated to determine if it can help manage muscle and joint pain associated with endocrine therapy in patients with early breast cancer.

ER Positive HER2 Negative Breast Cancer Stages I-II – This type of breast cancer is characterized by the presence of estrogen receptors (ER) and the absence of human epidermal growth factor receptor 2 (HER2) on the cancer cells. It typically occurs in the early stages, specifically stages I and II, where the cancer is localized to the breast or nearby lymph nodes. The cancer cells grow in response to estrogen, which can influence the progression of the disease. In these stages, the cancer is generally considered to be more treatable and may not have spread extensively. The progression can vary, but it often involves the growth of the tumor within the breast tissue and potentially to nearby lymph nodes. Monitoring and managing symptoms related to endocrine therapy, such as musculoskeletal pain, are important aspects of care.