Study on Oxytocin’s Effects on Trust and Learning in Healthy Children Using Nasal Spray

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What is this study about?

This clinical trial is focused on studying the effects of the hormone oxytocin on trust and learning in healthy children aged 9 to 13 years. Oxytocin is a naturally occurring hormone in the body, often associated with social bonding and trust. The study will use a nasal spray form of oxytocin, known as Syntocinon, to see how it influences trust and learning behaviors. Additionally, a simple saline solution, NaCl 0.9% nose drops, will be used as a comparison.

The purpose of the study is to explore how oxytocin affects trust learning and cognitive flexibility, which is the ability to adapt to new situations or changes. The study will involve activities that simulate real-life situations using virtual reality to observe how children learn to trust. Another task, called the Probabilistic Reversal Learning Task, will be used to see if oxytocin affects basic learning processes. This task helps researchers understand how children adjust their behavior when the rules of a game change.

Throughout the study, researchers will compare the behaviors of children who receive oxytocin with those who receive the placebo. They will look at how oxytocin might change the way children learn and trust others. The study aims to provide insights into whether oxytocin can influence social learning and behavior in children. The trial is expected to continue until March 2026.

1 joining the study

Upon joining the study, ensure that voluntary written informed consent has been obtained. This consent can be provided by you or your legally authorized representative.

Eligibility requires that participants are between 9 and 13 years old.

2 receiving medication

You will receive a nasal spray. This spray may contain either oxytocin or a placebo, which is a substance with no active medication.

The nasal spray is administered through the nose, known as intranasal use.

3 participating in the virtual reality experiment

Participate in a virtual reality (VR) experiment designed to study trust learning in a realistic setting.

This experiment will help evaluate the effects of oxytocin on trust behavior.

4 completing the cognitive flexibility task

Engage in a task called the Probabilistic Reversal Learning Task (PRLT). This task assesses cognitive flexibility, which is the ability to adapt to changing rules or environments.

The task will help determine if oxytocin affects learning at a basic level.

5 assessing trust behavior

Your trust behavior will be assessed by analyzing changes in self-reported trust before and after the test.

The study aims to understand how oxytocin influences trust behavior in different conditions.

6 monitoring attentional preference

The study will monitor attentional preference, particularly how oxytocin may affect responses to prediction errors.

This involves comparing performance on trials with and without prediction errors.

Who Can Join the Study?

  • The child must be a healthy participant.
  • The child must be between 9 and 13 years old.
  • There must be voluntary written informed consent from the child or their legally authorized representative before any screening procedures. This means that the child or their guardian agrees to participate in the study after understanding what it involves.
  • Both boys and girls can participate in the study.

Who Cannot Join the Study?

  • Children who are not healthy cannot participate.
  • Children who are not within the age range of 2 to 18 years old cannot participate.
  • Children who are part of a vulnerable population cannot participate. A vulnerable population includes groups who may not be able to give informed consent or are at higher risk of harm.

Where you can join this trial?

Verified and Recommended Sites

No sites found in this category

Verified Sites

Site Name City Country Status
Katholieke Universiteit te Leuven Leuven Belgium

Other Sites

No sites found in this category

Want to learn more about this study or check if you can participate? Contact us.

Trial status

Country Status Recruitment Start
Belgium Belgium
Recruiting
01.06.2024

Trial locations

Investigated drugs:

Oxytocin is a hormone that is naturally produced in the body and is often associated with social bonding and trust. In this clinical trial, oxytocin is being studied to see if it can influence how people learn to trust others. The researchers are interested in understanding whether oxytocin can make people more open to trusting others in a virtual reality setting. They are also looking at whether oxytocin affects other types of learning, not just social learning, by using a specific task designed to test cognitive flexibility. This task helps to see if oxytocin’s effects go beyond just social interactions and influence general learning abilities.

Healthy children – Healthy children are individuals in the developmental stage of life who do not exhibit any signs or symptoms of illness or disease. They typically experience normal growth and development, both physically and mentally. Their immune systems function effectively to protect against infections and diseases. Healthy children generally have regular sleep patterns, balanced nutrition, and engage in physical activities appropriate for their age. They also demonstrate typical cognitive and emotional development, allowing them to learn and interact socially. Regular health check-ups help ensure they maintain their well-being.

Trial ID:
2024-518004-49-00
Trial Phase:
Human Pharmacology (Phase I) – Other

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