Gastroenterology and Inflammatory Bowel Disease
Research activity includes Crohn’s disease, acute severe ulcerative colitis, pouchitis, short bowel syndrome, irritable bowel syndrome, functional dyspepsia, gastro-oesophageal reflux disease, and opioid-induced constipation.
- Inflammatory bowel disease surgery and recurrence
- Intestinal motility and upper gastrointestinal symptoms
- Supportive care in gastrointestinal disorders
Additional work spans infliximab treatment strategies, proton pump inhibitor deprescribing, and symptom-focused care in chronic digestive disease.
Oncology and Hematologic Malignancy
The oncology portfolio covers gastro-esophageal adenocarcinoma, pancreatic ductal adenocarcinoma, colorectal cancer, rectal cancer, breast cancer, prostate cancer, ovarian cancer, and malignant melanoma.
- Targeted treatment in receptor-defined cancers
- Metastasis-directed approaches in advanced solid tumors
- Perioperative and neoadjuvant cancer care
Studies also address febrile neutropenia, tumor imaging with PET/CT, and treatment selection in clinically challenging oncologic settings.
Neurology, Neurodegeneration, and Developmental Disorders
Clinical research includes Alzheimer disease, frontotemporal dementia, Lewy body disease, Parkinson’s disease, multiple system atrophy, amyotrophic lateral sclerosis, spinal muscular atrophy, autism spectrum disorder, cerebral palsy, traumatic brain injury, and drug-resistant epilepsy.
- Neurodegenerative disease characterization
- Motor and cognitive outcome assessment
- Pediatric neurodevelopmental care
Imaging and biomarker work extends to tau pathology, carotid atherosclerosis, and functional brain circuit studies.
Rheumatology, Dermatology, and Immune-Mediated Disease
Studies focus on rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, giant cell arteritis, IgG4-related disease, hidradenitis suppurativa, chronic rhinosinusitis with nasal polyps, and nonsteroidal anti-inflammatory drug-exacerbated respiratory disease.
- Biologic and targeted immune therapy
- Vasculitis and inflammatory airway disease
- Inflammatory skin and joint disorders
Research also addresses dupilumab, rituximab, tofacitinib, and anti-TNF strategies in immune-mediated conditions.
Perioperative Care, Critical Care, and Clinical Pharmacology
Trials span infective endocarditis, severe community-acquired pneumonia, prosthetic joint infections, fracture-related infections, cardiac surgery, obstetric and fetal surgery, and intensive care management in critically ill patients.
- Antimicrobial treatment optimization
- Perioperative analgesia and anesthesia
- Drug exposure and pharmacokinetics in complex care
Additional interests include ceftazidime-avibactam, clindamycin, apixaban, ketamine, oxytocin, and naloxegol.
