This clinical trial is focused on studying a type of liver cancer known as locoregional hepatocellular carcinoma (HCC). The study is exploring the effectiveness of a combination of treatments compared to a standard procedure called transarterial chemoembolization (TACE). The treatments being tested include Durvalumab, also known by its code name MEDI4736, Tremelimumab, and Lenvatinib. These treatments are being used together with TACE to see if they can improve outcomes for patients with this type of liver cancer.
The purpose of the study is to determine if the combination of these treatments is better than TACE alone in helping patients live longer without their cancer getting worse. The study will involve patients receiving either the combination of treatments or TACE alone. Some patients may also receive a placebo, which is a substance with no active medication, to help compare the effects of the treatments. The study will take place over a period of time, with regular check-ups and assessments to monitor the patients’ health and the progress of their cancer.
Participants in the study will receive the treatments through different methods. Durvalumab and Tremelimumab are given as a solution for infusion, which means they are administered directly into the bloodstream through a vein. Lenvatinib is taken orally in the form of hard capsules. The study aims to provide valuable information on whether this combination of treatments can offer a better option for patients with locoregional hepatocellular carcinoma.



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