Belzutifan is an oral tablet used to treat certain types of tumors by targeting the pathways that help these tumors grow and survive.

Lenvatinib is an oral capsule used to treat cancer by blocking specific proteins that help tumors grow new blood vessels, which can help starve the tumor of the nutrients it needs.

Renal cell carcinoma – This is a type of cancer that starts in the cells of the kidney. It typically begins in the lining of the small tubes within the kidney. The disease can grow into larger masses that may spread to other parts of the body.

Hepatocellular carcinoma – This is a primary type of liver cancer that develops in the main liver cells. It often develops in people with long-term liver damage or scarring. The abnormal cells grow and multiply, forming tumors within the liver tissue.

Non-MSI-H/dMMR colorectal cancer – This refers to cancer of the colon or rectum that does not have specific genetic markers called high microsatellite instability or mismatch repair deficiency. The disease begins in the cells lining the large intestine. It progresses as cells grow uncontrollably and form tumors in the digestive tract.

Pancreatic ductal adenocarcinoma – This is a cancer that originates in the ducts of the pancreas, which are the tubes that carry digestive juices. It is the most common form of pancreatic cancer. The disease starts in the lining of these ducts and spreads through the pancreatic tissue.

Biliary tract cancer – This group of cancers develops in the bile ducts, which are the tubes that carry bile from the liver to the gallbladder and small intestine. The disease can occur in the ducts inside the liver or those outside of it. It progresses as abnormal cells form tumors within the biliary system.

Non-MSIH/dMMR endometrial cancer – This is a type of cancer that starts in the lining of the uterus and lacks specific genetic instability markers. It begins in the endometrial cells. The disease progresses as these cells multiply and expand within the uterine cavity.

Esophageal squamous cell carcinoma – This is a cancer that forms in the squamous cells, which are the flat cells lining the esophagus. The esophagus is the tube that connects the throat to the stomach. The disease develops when these cells undergo abnormal changes and form growths.

Advanced Pheochromocytoma/Paraganglioma – These are tumors that arise from specialized cells that produce hormones. Pheochromocytomas develop in the adrenal glands, while paragangliomas develop in other parts of the nervous system. The disease involves the uncontrolled growth of these cells and the potential overproduction of hormones.

Pancreatic neuroendocrine tumor – This is a type of cancer that begins in the hormone-producing cells of the pancreas. Unlike common pancreatic cancers, these arise from neuroendocrine cells. The disease progresses as these specific cells form tumors within the pancreatic organ.

von Hippel-Lindau disease-associated tumors – These are various tumors that occur in individuals with a specific genetic condition. The tumors can develop in many different organs, such as the kidneys, brain, or pancreas. The disease is characterized by the development of multiple abnormal growths due to genetic factors.

Advanced Gastrointestinal Stromal Tumor – This is a type of cancer that develops in the digestive tract, most commonly in the wall of the stomach or small intestine. It arises from specialized cells called interstitial cells of Cajal. The disease progresses as these cells form tumors that can grow within or around the digestive organs.

Advanced Solid Tumors With HIF-2α related Genetic Alterations – This refers to various types of solid cancers that have specific changes in the HIF-2α gene. These genetic changes influence how cells respond to low oxygen levels. The disease progresses as these altered cells grow and form solid masses in the body.