Skip to content
Clinical Trials – home

Rare diseases

Investigational molecules

Locations

Our offerNewsroom

Not recruiting

Study on the Effects of Upadacitinib in Adults with Moderate to Severe Systemic Lupus Erythematosus (SLE)

Fast replyInvestigationalNo placebo
Clinical Trials Concierge

Prefer not to search? Our Concierge searches the trials for you.

What is this trial about?

A plain-language summary of the goals, design and what participants do

This clinical trial is focused on studying the effects of a medication called Upadacitinib on individuals with Systemic Lupus Erythematosus (SLE), a condition where the immune system mistakenly attacks healthy tissues in the body, causing inflammation and damage. The study aims to evaluate the safety and effectiveness of Upadacitinib, which is taken as a modified-release tablet, in adults who have moderate to severe SLE. Participants in the study will either receive Upadacitinib or a placebo, which is a substance with no active medication, to compare the outcomes.

The purpose of the study is to assess how well Upadacitinib works in reducing the signs and symptoms of SLE over a period of 52 weeks. The study is divided into two main parts: the first part involves two similar studies that will last for 52 weeks, and the second part is a long-term extension to further evaluate the safety of Upadacitinib. Participants will be monitored regularly to track any changes in their condition and to ensure their safety throughout the study.

During the trial, participants will continue their usual background treatments for SLE, which may include medications like hydroxychloroquine or prednisone, among others. The study will measure various outcomes, such as the reduction in disease activity and improvement in symptoms, to determine the effectiveness of Upadacitinib compared to the placebo. The trial is expected to provide valuable information on the potential benefits of Upadacitinib for people living with SLE.

The research process

The trial runs in 6 steps – from screening to follow-up. Each step says what happens and what the team monitors.

  1. Step 1

    Initial assessment

    Upon joining the study, an initial assessment is conducted to confirm eligibility. This includes verifying a clinical diagnosis of systemic lupus erythematosus (SLE) and ensuring stable background treatment for at least 60 days prior to the baseline visit.

  2. Step 2

    Baseline visit

    During the baseline visit, the clinical score is re-confirmed. The patient must have a specific score on the hSLEDAI scale, which measures disease activity, to proceed.

  3. Step 3

    Treatment phase

    The treatment phase lasts for 52 weeks. Patients receive either upadacitinib or a placebo. Upadacitinib is administered as a modified-release tablet taken orally.

    The objective is to evaluate the safety and effectiveness of upadacitinib in reducing the signs and symptoms of SLE.

  4. Step 4

    Regular assessments

    Throughout the 52-week period, regular assessments are conducted to monitor the patient's response to treatment. These include evaluating the achievement of a BICLA response, flare rates, and other health indicators.

  5. Step 5

    End of treatment evaluation

    At the end of the 52-week treatment period, a final evaluation is conducted to assess the overall effectiveness and safety of the treatment.

  6. Step 6

    Long-term extension

    For those continuing into the long-term extension study, the focus is on evaluating the long-term safety of upadacitinib in managing SLE.

Who can join the trial?

8 criteria

  • Must be an adult between 18 and 63 years old.
  • Must have been diagnosed with Systemic Lupus Erythematosus (SLE) at least 24 weeks before the screening. SLE is a condition where the immune system attacks the body's own tissues.
  • At screening, must have at least one of the following positive tests: ANA+ (a test for antinuclear antibodies), anti-dsDNA+ (a test for antibodies against double-stranded DNA), or anti-Smith+ (a test for antibodies against a specific protein).
  • Must have a hSLEDAI score of 6 or more, with at least 4 points from clinical symptoms. hSLEDAI is a tool used to measure disease activity in SLE. The score must be confirmed at the baseline visit.
  • Must have a PhGA score of 1 or more during the screening period. PhGA is a physician's global assessment of the disease.
  • Must be on stable treatment for at least 60 days before the baseline visit, except for oral corticosteroids, which must be stable for at least 14 days. Treatment can include:
    • Antimalarial medications like hydroxychloroquine, chloroquine, or quinacrine.
    • Prednisone or similar medications, up to 20 mg daily.
    • No more than one of the following: azathioprine, 6-mercaptopurine, mycophenolate mofetil, mycophenolate sodium, leflunomide, cyclosporine, tacrolimus, voclosporin, methotrexate, or mizoribine.

Who cannot join the trial?

427 criteria

  • Patients who have any other serious health condition that could interfere with the study.
  • Patients who are pregnant or breastfeeding.
  • Patients who have a history of severe allergic reactions to medications.
  • Patients who have an active infection that requires treatment.
  • Patients who have received certain treatments for SLE within a specific time frame before the study.
  • Patients who have a history of cancer, except for certain types of skin cancer that have been treated.
  • Patients who have a history of drug or alcohol abuse.
  • Patients who have participated in another clinical trial within a certain period before this study.
  • Patients who have a condition that affects their immune system, other than SLE.
  • Patients who have a history of blood clotting disorders.
  • Patients who have a history of heart problems.
  • Patients who have a history of liver disease.
  • Patients who have a history of kidney disease.
  • Patients who have a history of lung disease.
  • Patients who have a history of neurological disorders, which are problems with the brain or nerves.
  • Patients who have a history of psychiatric disorders, which are mental health conditions.
  • Patients who have a history of gastrointestinal disorders, which are problems with the stomach or intestines.
  • Patients who have a history of blood disorders.
  • Patients who have a history of metabolic disorders, which are problems with how the body uses food and energy.
  • Patients who have a history of endocrine disorders, which are problems with glands that produce hormones.
  • Patients who have a history of musculoskeletal disorders, which are problems with muscles and bones.
  • Patients who have a history of skin disorders.
  • Patients who have a history of eye disorders.
  • Patients who have a history of ear disorders.
  • Patients who have a history of nose or throat disorders.
  • Patients who have a history of dental disorders.
  • Patients who have a history of reproductive disorders.
  • Patients who have a history of urinary disorders.
  • Patients who have a history of immune disorders, which are problems with the body's defense system.
  • Patients who have a history of hematological disorders, which are problems with blood cells.
  • Patients who have a history of oncological disorders, which are problems related to cancer.
  • Patients who have a history of genetic disorders, which are problems passed down from parents to children.
  • Patients who have a history of congenital disorders, which are problems present at birth.
  • Patients who have a history of developmental disorders, which are problems with growth and development.
  • Patients who have a history of nutritional disorders, which are problems with diet and nutrition.
  • Patients who have a history of environmental disorders, which are problems caused by surroundings or conditions.
  • Patients who have a history of occupational disorders, which are problems caused by work or job conditions.
  • Patients who have a history of social disorders, which are problems related to social interactions.
  • Patients who have a history of psychological disorders, which are problems related to mental health.
  • Patients who have a history of behavioral disorders, which are problems related to behavior.
  • Patients who have a history of cognitive disorders, which are problems related to thinking and understanding.
  • Patients who have a history of emotional disorders, which are problems related to feelings and emotions.
  • Patients who have a history of sensory disorders, which are problems related to senses like sight and hearing.
  • Patients who have a history of motor disorders, which are problems related to movement.
  • Patients who have a history of speech disorders, which are problems related to speaking.
  • Patients who have a history of language disorders, which are problems related to understanding and using language.
  • Patients who have a history of learning disorders, which are problems related to learning and education.
  • Patients who have a history of memory disorders, which are problems related to remembering things.
  • Patients who have a history of attention disorders, which are problems related to focusing and paying attention.
  • Patients who have a history of sleep disorders, which are problems related to sleeping.
  • Patients who have a history of eating disorders, which are problems related to eating habits.
  • Patients who have a history of sexual disorders, which are problems related to sexual health.
  • Patients who have a history of gender disorders, which are problems related to gender identity.
  • Patients who have a history of identity disorders, which are problems related to self-identity.
  • Patients who have a history of personality disorders, which are problems related to personality traits.
  • Patients who have a history of mood disorders, which are problems related to mood and emotions.
  • Patients who have a history of anxiety disorders, which are problems related to anxiety and worry.
  • Patients who have a history of stress disorders, which are problems related to stress and pressure.
  • Patients who have a history of trauma disorders, which are problems related to past traumatic experiences.
  • Patients who have a history of abuse disorders, which are problems related to abuse or mistreatment.
  • Patients who have a history of neglect disorders, which are problems related to neglect or lack of care.
  • Patients who have a history of dependency disorders, which are problems related to dependency on substances or behaviors.
  • Patients who have a history of addiction disorders, which are problems related to addiction to substances or behaviors.
  • Patients who have a history of withdrawal disorders, which are problems related to withdrawal from substances or behaviors.
  • Patients who have a history of tolerance disorders, which are problems related to tolerance to substances or behaviors.
  • Patients who have a history of intoxication disorders, which are problems related to intoxication from substances or behaviors.
  • Patients who have a history of overdose disorders, which are problems related to overdose from substances or behaviors.
  • Patients who have a history of poisoning disorders, which are problems related to poisoning from substances or behaviors.
  • Patients who have a history of exposure disorders, which are problems related to exposure to substances or behaviors.
  • Patients who have a history of contamination disorders, which are problems related to contamination from substances or behaviors.
  • Patients who have a history of infection disorders, which are problems related to infections from substances or behaviors.
  • Patients who have a history of infestation disorders, which are problems related to infestations from substances or behaviors.
  • Patients who have a history of inflammation disorders, which are problems related to inflammation from substances or behaviors.
  • Patients who have a history of irritation disorders, which are problems related to irritation from substances or behaviors.
  • Patients who have a history of allergy disorders, which are problems related to allergies from substances or behaviors.
  • Patients who have a history of hypersensitivity disorders, which are problems related to hypersensitivity from substances or behaviors.
  • Patients who have a history of intolerance disorders, which are problems related to intolerance from substances or behaviors.
  • Patients who have a history of sensitivity disorders, which are problems related to sensitivity from substances or behaviors.
  • Patients who have a history of reactivity disorders, which are problems related to reactivity from substances or behaviors.
  • Patients who have a history of susceptibility disorders, which are problems related to susceptibility from substances or behaviors.
  • Patients who have a history of vulnerability disorders, which are problems related to vulnerability from substances or behaviors.
  • Patients who have a history of fragility disorders, which are problems related to fragility from substances or behaviors.
  • Patients who have a history of weakness disorders, which are problems related to weakness from substances or behaviors.
  • Patients who have a history of fatigue disorders, which are problems related to fatigue from substances or behaviors.
  • Patients who have a history of exhaustion disorders, which are problems related to exhaustion from substances or behaviors.
  • Patients who have a history of burnout disorders, which are problems related to burnout from substances or behaviors.
  • Patients who have a history of depletion disorders, which are problems related to depletion from substances or behaviors.
  • Patients who have a history of deficiency disorders, which are problems related to deficiency from substances or behaviors.
  • Patients who have a history of insufficiency disorders, which are problems related to insufficiency from substances or behaviors.
  • Patients who have a history of inadequacy disorders, which are problems related to inadequacy from substances or behaviors.
  • Patients who have a history of incompetence disorders, which are problems related to incompetence from substances or behaviors.
  • Patients who have a history of incapacity disorders, which are problems related to incapacity from substances or behaviors.
  • Patients who have a history of disability disorders, which are problems related to disability from substances or behaviors.
  • Patients who have a history of impairment disorders, which are problems related to impairment from substances or behaviors.
  • Patients who have a history of handicap disorders, which are problems related to handicap from substances or behaviors.
  • Patients who have a history of limitation disorders, which are problems related to limitation from substances or behaviors.
  • Patients who have a history of restriction disorders, which are problems related to restriction from substances or behaviors.
  • Patients who have a history of constraint disorders, which are problems related to constraint from substances or behaviors.
  • Patients who have a history of inhibition disorders, which are problems related to inhibition from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
  • Patients who have a history of suppression disorders, which are problems related to suppression from substances or behaviors.
  • Patients who have a history of repression disorders, which are problems related to repression from substances or behaviors.
  • Patients who have a history of oppression disorders, which are problems related to oppression from substances or behaviors.
  • Patients who have a history of depression disorders, which are problems related to depression from substances or behaviors.
Clinical Trials Concierge

Prefer not to search? Our Concierge searches the trials for you.

Tell us about your condition – we search every trial in Europe and connect you with the right site.

We usually reply within a few days

Verified sites

All sites with verified contact details – recruitment status may not be available; ask directly

Trial locations

Where you can join this trial

Countries are shaded by recruitment status. Click a recruiting country to ask about joining there.

Not recruiting
Not finding your country?

Not sure what to do next?

Joining a clinical trial can seem overwhelming. We guide you step by step, so you know exactly what to expect and how we support you through the process.

See the full process and FAQ

Investigated drugs

Upadacitinib is a medication being studied for its ability to treat signs and symptoms of moderately to severely active Systemic Lupus Erythematosus (SLE). The trial aims to assess both the safety and effectiveness of this medication over a period of 52 weeks. Upadacitinib is being compared to a placebo to determine if it provides superior results in managing SLE symptoms. Additionally, the study includes a long-term extension to further evaluate the safety of upadacitinib in patients with SLE.

What is already known about the treatment

Upadacitinib – This medication is administered orally and is currently being evaluated in clinical trials for its safety and effectiveness in treating Systemic Lupus Erythematosus (SLE). It is in the late stages of clinical research, specifically Phase 3 trials, and is not yet widely available for this condition. Upadacitinib is primarily indicated for individuals with moderately to severely active SLE. It works by inhibiting certain enzymes known as Janus kinases (JAKs), which play a role in the inflammatory process. This medication is classified as a JAK inhibitor, a type of drug that helps reduce inflammation and immune system activity.

Investigated diseases

Systemic Lupus Erythematosus – Systemic Lupus Erythematosus (SLE) is an autoimmune disease where the immune system mistakenly attacks healthy tissues in the body. It can affect various parts of the body, including the skin, joints, kidneys, brain, and other organs. The disease often presents with symptoms such as fatigue, joint pain, skin rashes, and fever. SLE is characterized by periods of illness, called flares, and periods of remission when symptoms improve. The severity and progression of the disease can vary widely among individuals. Over time, SLE can lead to complications in the affected organs if not managed properly.
Trial detailsLast updated 2 Oct 2026
Age18+ yearsPhasePhase IIITrial ID2023-503655-10-00Protocol codeM23-699Estimated enrolment986 patientsSponsorAbbVie Deutschland GmbH & Co. KG

sourced from the EU Clinical Trials Register and site verification

Want to learn more about this trial or check if you can participate?

Clinical Trials Concierge

Prefer not to search? Our Concierge searches the trials for you.

Tell us about your condition – we search every trial in Europe and connect you with the right site.

ClinicalTrials.eu

Every clinical trial in Europe, in plain language.

Explore the full ecosystem of clinical research in Europe.

Search trials

Legal notice · Published by CTIN POLAND sp. z o.o., ul. rtm. Witolda Pileckiego 67/109, 02-781 Warsaw, Poland · KRS 0001111334 · REGON 528919042 · NIP 9512598637

© 2026 Clinical Trials EU – European Clinical Trials Information Network

GDPR compliance, ISO 9001 and ISO 27001 certified (LL-C Certification)

On this site, “treatment” means an investigational medicine being studied in a clinical trial. Its safety and efficacy for the use being studied have not yet been confirmed, some participants may receive a placebo or a comparator medicine, and taking part does not guarantee any health benefit. The decision to take part is made by the doctor at the research site. This site is for information only and does not replace medical advice.

This service is not affiliated with the European Commission, the EMA, or the official CTIS system. Most information comes from publicly available international clinical-trial registries, supplemented by data from academic sites, national regulators and commercial sponsors. On this site, “treatment” and “therapy” mean a medicine being tested in a clinical trial. Its safety and effectiveness in the use being studied are not yet confirmed, some participants may receive a placebo or a comparator, and taking part does not guarantee a health benefit. The doctor at the research site decides who can take part. This site provides information, not medical advice. Certain content and visual elements on this website have been generated or enhanced using artificial intelligence (AI).