This clinical trial is focused on studying the effects of two medications, Phenylephrine and Noradrenaline Tartrate, on patients experiencing low blood pressure during anesthesia. These medications are used to help manage blood pressure levels during surgery. The study aims to understand how these medications affect blood flow and oxygen levels in the brain, as well as their impact on the heart and muscles, in patients undergoing surgery to remove brain tumors.

The trial involves patients who are scheduled for a specific type of brain surgery called a craniotomy, which is performed to remove tumors from the brain. During the study, participants will receive either Phenylephrine or Noradrenaline Tartrate through an intravenous infusion, which means the medication is delivered directly into the bloodstream. The goal is to observe any differences in how these medications affect the body’s circulation and the brain’s oxygen supply.

The study will monitor changes in blood flow and oxygenation before and after treatment with these medications. By comparing the effects of Phenylephrine and Noradrenaline Tartrate, researchers hope to gain insights into which medication might be more beneficial for maintaining stable blood pressure and ensuring adequate blood flow to the brain during surgery. This research is part of an international effort to improve outcomes for patients undergoing brain tumor surgery.