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This study focuses on pain management during major gastrointestinal surgery or abdominal surgery performed through laparotomy (a large surgical cut in the abdomen). The research examines the effectiveness of combining two pain relief methods: intravenous lidocaine (a numbing medication given through a vein) and intrathecal morphine (pain medication injected into the spinal fluid).
The main purpose is to determine if adding intravenous lidocaine to spinal morphine works better than using a placebo with spinal morphine for reducing the need for additional pain medication after surgery. The study compares two groups of patients - one receiving lidocaine and the other receiving placebo, along with spinal morphine.
During the study, patients undergo their planned abdominal surgery and receive either lidocaine or placebo through an intravenous line. The medication or placebo is given during and after the operation. Both groups receive spinal morphine as part of their pain management plan. The amount of additional pain medication needed and any side effects are monitored for several days after surgery.
The trial runs in 5 steps – from screening to follow-up. Each step says what happens and what the team monitors.
13 criteria
15 criteria
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is a local anesthetic medication given through an intravenous (IV) line directly into the bloodstream. It helps reduce pain and is commonly used during and after surgery. In this trial, it is being tested to see if it can help reduce the need for other pain medications after major abdominal surgery.
is a strong pain medication that belongs to the opioid family. In this trial, it is given through spinal anesthesia (injected into the spine) to help control pain during and after abdominal surgery. This method of delivery is called intrathecal or spinal morphine administration.
A local anesthetic medication administered intravenously in combination with spinal morphine anesthesia for major gastrointestinal and abdominal surgery. This medication belongs to the class of sodium channel blockers and works by temporarily blocking nerve signals in the body, helping to reduce postoperative pain and decrease the need for additional morphine consumption after surgery. Lidocaine's intravenous administration in this context represents an innovative approach to multimodal pain management, with clinical trials investigating its potential benefits in reducing overall opioid requirements during the first 48 hours following major surgical procedures.
A powerful opioid analgesic administered through spinal (intrathecal) injection for pain management during and after major abdominal surgery. As a member of the opioid class of medications, morphine works by binding to specific receptors in the central nervous system to provide strong pain relief during surgical procedures. When administered through spinal anesthesia, it provides targeted pain control with lower doses compared to other routes of administration, making it an effective choice for major surgical procedures requiring laparotomy.
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