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Study on Sodium Bicarbonate and Sodium Chloride for Patients with In-Hospital Cardiac Arrest

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What is this trial about?

A plain-language summary of the goals, design and what participants do

This clinical trial is focused on studying the treatment of in-hospital cardiac arrest, a condition where the heart suddenly stops beating while a patient is in the hospital. The trial will investigate whether using a treatment called sodium bicarbonate can help improve the chances of the heart starting to beat again on its own, compared to a placebo. Sodium bicarbonate is a chemical compound that is sometimes used in medical emergencies to help balance the body's pH levels.

Participants in the study will receive either sodium bicarbonate or a placebo during the event of a cardiac arrest while they are in the hospital. The treatment will be given through an intravenous injection, which means it will be administered directly into a vein. The main goal of the study is to see if sodium bicarbonate can increase the likelihood of the heart resuming its normal function, known as the return of spontaneous circulation.

The study will also look at other important outcomes, such as survival rates 30 days after the cardiac arrest and whether patients have a favorable neurological outcome, which refers to the brain's ability to function well after the event. This will be assessed using a scale that measures the level of disability. The trial is designed to provide valuable information on whether sodium bicarbonate can be an effective treatment during in-hospital cardiac arrest.

The research process

The trial runs in 4 steps – from screening to follow-up. Each step says what happens and what the team monitors.

  1. Step 1

    Joining the trial

    Upon joining the trial, you will be informed about the study's purpose, which is to determine if **sodium bicarbonate** can help during an in-hospital cardiac arrest.

    You will be eligible to participate if you are 18 years or older, have experienced an in-hospital cardiac arrest, and have received at least one dose of adrenaline during cardiopulmonary resuscitation.

  2. Step 2

    Treatment administration

    During the trial, you may receive an intravenous injection of **sodium bicarbonate** or a placebo. This will be administered as a solution for infusion.

    The treatment is given during the cardiac arrest event to assess its effectiveness in increasing the return of spontaneous circulation.

  3. Step 3

    Monitoring and follow-up

    After the treatment, your health will be monitored to check for the return of spontaneous circulation, which is the primary goal of the study.

    Your survival will be assessed at 30 days, along with your neurological outcome, using a scale that measures your ability to perform daily activities.

  4. Step 4

    End of trial

    The trial is expected to conclude by October 31, 2026. Your participation will contribute to understanding the potential benefits of **sodium bicarbonate** in treating cardiac arrest.

Who can join the trial?

3 criteria

  • The patient must have experienced an in-hospital cardiac arrest. This means their heart stopped beating while they were in the hospital.
  • The patient must be 18 years old or older.
  • The patient must have received at least one dose of adrenaline during cardiopulmonary resuscitation (CPR). Adrenaline is a medication used to help restart the heart.

Who cannot join the trial?

4 criteria

  • Patients who have not experienced an in-hospital cardiac arrest cannot participate. In-hospital cardiac arrest means the heart stops beating while the patient is in the hospital.
  • Patients who are not within the specified age range cannot participate. The age range includes adults and older adults.
  • Patients who are not part of the specified clinical trial group cannot participate. This group includes both males and females.
  • Patients who are considered part of a vulnerable population cannot participate. A vulnerable population refers to groups of people who may be at a higher risk of harm or exploitation.
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Investigated drugs

Sodium Bicarbonate is a medication used in this clinical trial to help treat patients who experience cardiac arrest while in the hospital. Cardiac arrest is when the heart suddenly stops beating, and it is a life-threatening emergency. Sodium bicarbonate is being tested to see if it can help the heart start beating again on its own. It works by helping to balance the acid levels in the blood, which can be disrupted during cardiac arrest. The goal of using sodium bicarbonate in this trial is to see if it can improve the chances of the heart starting to beat again without assistance.

What is already known about the treatment

Sodium Bicarbonate – Sodium bicarbonate is administered intravenously, meaning it is given directly into a vein through an injection or an IV drip. It is currently being studied in clinical trials to assess its effectiveness during in-hospital cardiac arrest, a condition where the heart suddenly stops beating while a patient is in the hospital. The main therapeutic indication for sodium bicarbonate in this context is to help restore the heart's normal rhythm and circulation. At the molecular level, sodium bicarbonate works by neutralizing excess acid in the blood, which can occur during cardiac arrest, potentially helping the heart to function better. It is classified pharmacologically as an alkalinizing agent, which means it helps to balance the pH levels in the body.

Investigated diseases

In-hospital cardiac arrest – In-hospital cardiac arrest occurs when the heart suddenly stops beating effectively while a patient is in a hospital setting. This condition leads to a cessation of blood flow to the brain and other vital organs. It typically progresses rapidly, requiring immediate medical intervention to restore circulation. The lack of blood flow can cause loss of consciousness and absence of pulse. If untreated, it can lead to severe damage to the brain and other organs due to lack of oxygen. The primary goal during an in-hospital cardiac arrest is to achieve the return of spontaneous circulation, which means the heart starts beating on its own again.
Trial detailsLast updated 2 Oct 2026
Age18+ yearsPhasePhase IIITrial ID2022-501304-10-00Estimated enrolment778 patientsSponsorRegion Midtjylland

sourced from the EU Clinical Trials Register and site verification

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