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Study on the Effect of Adrenaline, Vasopressin, and Steroids on Survival in Cardiac Arrest Patients

Verified siteRegistered drugNo placebo
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What is this trial about?

A plain-language summary of the goals, design and what participants do

This clinical trial is focused on studying the effects of a combination of medications on patients experiencing a cardiac arrest, which is when the heart suddenly stops beating. The study will use a combination of three medications: adrenaline (also known as epinephrine), vasopressin (also known as argipressin), and steroids such as hydrocortisone and methylprednisolone. These medications are administered through an injection directly into the veins.

The purpose of the study is to determine if using this combination of medications can improve the chances of survival for patients 30 days after experiencing a cardiac arrest, compared to using adrenaline alone. During the study, some patients will receive the combination of medications, while others will receive only adrenaline. The study will monitor the patients' health and survival over a period of time to gather results.

Participants in the study will be those who have experienced a cardiac arrest in a hospital setting and meet certain criteria for receiving adrenaline. The study aims to provide valuable information on whether this combination of medications can offer better outcomes for cardiac arrest patients.

The research process

The trial runs in 4 steps – from screening to follow-up. Each step says what happens and what the team monitors.

  1. Step 1

    Joining the trial

    Upon joining the trial, you will be informed about the study's purpose, which is to determine if a combination of medications can improve survival after a cardiac arrest.

    You will be asked to provide consent to participate in the study.

  2. Step 2

    Treatment administration

    During the trial, you will receive medications through an intravenous (IV) line. This means the medications will be given directly into your bloodstream.

    The medications include adrenaline, vasopressin, and steroids such as hydrocortisone and methylprednisolone.

    The specific dosages and frequency of administration will be determined by the medical team based on the study protocol.

  3. Step 3

    Monitoring and follow-up

    You will be closely monitored by the medical team throughout the trial to assess your response to the treatment.

    The primary goal is to evaluate your survival at 30 days after the cardiac arrest event.

  4. Step 4

    Completion of the trial

    The trial is expected to continue until December 27, 2029.

    Your participation will contribute to understanding the effectiveness of the treatment in improving survival rates after cardiac arrest.

Who can join the trial?

4 criteria

  • Patients who have experienced a cardiac arrest while in the hospital. Cardiac arrest is when the heart suddenly stops beating.
  • Patients must meet the criteria for receiving adrenaline as per the current ERC guidelines. Adrenaline is a medication used in emergencies to help restart the heart.
  • Both male and female patients can participate.
  • Patients must be within the age range of 18 to 65 years old.

Who cannot join the trial?

1 criterion

  • Patients who have experienced a cardiac arrest cannot participate. A cardiac arrest is when the heart suddenly stops beating.
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Investigated drugs

  • Adrenaline

    is a medication used in emergency situations to help restart the heart when it has stopped beating, a condition known as cardiac arrest. It works by stimulating the heart and increasing blood flow, which can help restore a normal heartbeat.

  • Vasopressin

    is a medication that helps to increase blood pressure by narrowing blood vessels. In the context of cardiac arrest, it is used to improve blood flow to vital organs, which can be crucial in helping the heart to start beating again.

  • Steroids

    are medications that can reduce inflammation and improve the body's response to stress. In this trial, they are used alongside other medications to potentially improve the chances of survival after a cardiac arrest by supporting the body's recovery processes.

What is already known about the treatment

  • Adrenaline

    Adrenaline is administered through an injection, typically into a vein, during emergency situations like cardiac arrest. It is a well-established medication in medical practice and literature, primarily used to help restart the heart when it has stopped beating. Adrenaline works by stimulating the heart and increasing blood flow, which can help restore a normal heartbeat. It belongs to a class of drugs known as vasopressors, which are used to raise blood pressure and improve circulation during critical conditions.

  • Vasopressin

    Vasopressin is given as an injection, often in a hospital setting, during severe medical emergencies such as cardiac arrest. It is recognized in medical literature as a supportive treatment to improve outcomes in cardiac arrest patients. Vasopressin helps by constricting blood vessels, which increases blood pressure and improves blood flow to vital organs. It is classified as a vasopressor, similar to adrenaline, and is used to enhance the effects of other medications during resuscitation efforts.

  • Steroids

    Steroids, in this context, are administered via injection during cardiac arrest to support the body's stress response. They are well-documented in medical literature for their role in reducing inflammation and supporting heart function during critical situations. Steroids work by modulating the body's immune response and enhancing the effects of other resuscitation drugs. They are part of a broader class of medications known as corticosteroids, which are used to manage inflammation and support recovery in various medical conditions.

Investigated diseases

Cardiac arrest – Cardiac arrest is a sudden loss of heart function, leading to a stop in effective blood circulation. It occurs when the heart's electrical system malfunctions, causing an irregular heartbeat or arrhythmia. This disruption prevents the heart from pumping blood to the brain, lungs, and other organs. Without immediate intervention, the lack of blood flow can lead to unconsciousness and cessation of breathing. The condition progresses rapidly, requiring urgent medical attention to restore normal heart rhythm. It is distinct from a heart attack, which is caused by a blockage that stops blood flow to the heart muscle.
Trial detailsLast updated 7 Oct 2026
Age18+ yearsPhasePhase IIITrial ID2025-521283-35-00Estimated enrolment1 400 patientsSponsorTiohundra AB

sourced from the EU Clinical Trials Register and site verification

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