This clinical trial studies the treatment of febrile Urinary Tract Infection (fever with urinary infection) caused by Escherichia coli bacteria. The study compares two treatment approaches: one using pivmecillinam tablets and another using standard care medications. The infection being studied typically causes symptoms like fever, pain in the lower back or pelvis area, frequent urination, and discomfort while urinating.
The treatments used in this study include various antibiotics that can be given either through a vein (intravenous) or by mouth. Some of these medications are amoxicillin, ciprofloxacin, ceftriaxone, and several others. The study starts with giving antibiotics through a vein until the fever goes away and the patient’s condition improves. Then, depending on which group the patient is assigned to, they will either receive pivmecillinam tablets or continue with standard treatment.
The study will check how well the treatments work by monitoring if symptoms improve, if the fever stays away, and if the infection clears up. The researchers will also look at side effects of the medications, how the treatments affect bacteria in the digestive system, and which treatment approach is more cost-effective. The study is expected to run for several years, starting in 2025.
Norway 
Sweden 
