After joining the study, you will begin the treatment period. This study compares finerenone to placebo (a dummy medication with no active ingredient).

You will be randomly assigned to receive either finerenone or placebo. This assignment is done by chance, like flipping a coin, and neither you nor your doctor will know which one you are receiving. This is called a double-blind study.

The study medication will be given in addition to your current standard-of-care treatment for heart failure, which means you will continue taking your regular medications as prescribed by your doctor.

You will take the study medication by mouth (oral route). The medication comes in the form of film-coated tablets or granules for oral suspension, depending on what is suitable for you.

Your doctor will determine the appropriate dose based on your age, weight, and medical condition.

You must take the study medication regularly as instructed throughout the treatment period.

At 3 months after starting the study medication, your doctor will measure the levels of a substance called NT-proBNP in your blood. This substance is a marker that helps doctors understand how well your heart is working.

This measurement will be compared to the level measured before you started the study medication to see if there has been any change.

Throughout the study, you will have regular visits where your doctor will monitor your health and safety.

During these visits, your doctor will check for any side effects or unwanted reactions to the study medication. These are called treatment-emergent adverse events.

Your doctor will measure your blood pressure, specifically the top number known as systolic blood pressure.

Blood tests will be performed to check your potassium levels and kidney function.

You will have echocardiography tests, which use sound waves to create pictures of your heart. These tests will show how well your heart is pumping and its size.

Your doctor will also monitor for any serious heart-related events, such as worsening of heart failure symptoms.

At the end of treatment, your doctor will perform final assessments.

These assessments will include measurements of potassium levels, blood pressure, kidney function, and heart function using echocardiography.

All of these measurements will be compared to the ones taken before you started the study medication to evaluate any changes.

At certain times during the study, blood samples will be taken to measure how much finerenone is in your blood.

These measurements help doctors understand how the medication moves into, through, and out of your body. This is called studying the pharmacokinetics of the medication.

The measurements include the maximum concentration of finerenone in your blood and the total amount of the medication in your blood over time.