Digestive System Diseases

The gastroenterology unit is evaluating new oral therapies to maintain remission in patients with Crohn’s disease.

  • Upadacitinib as maintenance therapy
  • Long‑term safety monitoring
  • Patient‑reported outcomes
  • Dose optimization strategies

At Centro Hospitalar Universitario Sao Joao E.P.E. more than 80 investigators contribute to a portfolio of 10 active studies.

Nervous System Diseases

A precision‑medicine study targets motor decline in individuals with Parkinson’s disease carrying a GBA1 mutation.

  • Genotype‑guided therapy
  • Motor function scales
  • Safety and tolerability assessments
  • Impact on daily living

The trial aims to improve quality of life for patients while advancing personalized treatment options.

Cardiovascular Diseases

A comparative trial examines whether asundexian can safely reduce stroke risk in patients with atrial fibrillation.

  • Efficacy in preventing stroke
  • Major bleeding outcomes
  • Benefit‑risk balance
  • Patient adherence

Findings will inform anticoagulation strategies for individuals at high risk of thrombo‑embolic events.

Virus Diseases

Researchers assess continued viral suppression after switching to a simplified DTG/3TC regimen in treatment‑experienced adults living with HIV.

  • Virologic control
  • Safety profile
  • Treatment convenience
  • Long‑term outcomes

The study supports therapeutic options that reduce pill burden for aging patients.

Congenital, Hereditary, and Neonatal Diseases

A gene‑therapy approach is being tested for safety and copper regulation in patients with Wilson disease. Parallel research evaluates long‑term prophylaxis with a novel agent in individuals with haemophilia A.

  • Gene delivery vectors
  • Copper excretion monitoring
  • Inhibitor management strategies
  • Pediatric safety data

Collaboration across several European countries enhances the robustness of these rare‑disease investigations.