Oncology and Hematologic Malignancies
Breast cancer, non-small cell lung cancer, small cell lung cancer, prostate cancer, and colorectal cancer are central areas of interest, alongside studies in ovarian cancer, head and neck squamous cell carcinoma, esophageal cancer, hepatocellular carcinoma, and bladder cancer. Research also extends to blood cancers such as multiple myeloma, diffuse large B-cell lymphoma, follicular lymphoma, acute lymphoblastic leukemia, and advanced lymphomas.
- HER2-negative and hormone receptor-positive breast cancer
- Advanced solid tumors
- Relapsed or refractory multiple myeloma
- Diffuse large B-cell lymphoma
- Metastatic castration-resistant prostate cancer
Additional oncology work includes melanoma, non-muscle invasive bladder cancer, liposarcoma, and neuroblastoma, with a strong emphasis on advanced and metastatic disease settings.
Inflammatory and Autoimmune Disorders
Clinical research spans rheumatoid arthritis, systemic lupus erythematosus, cutaneous lupus erythematosus, idiopathic inflammatory myopathies, and juvenile idiopathic arthritis. The portfolio also includes immune-mediated skin and bowel diseases such as atopic dermatitis, alopecia areata, vitiligo, ulcerative colitis, Crohn’s disease, and eosinophilic esophagitis.
- Atopic dermatitis
- Vitiligo
- Ulcerative colitis
- Rheumatoid arthritis
- Systemic lupus erythematosus
Other immune-focused studies address chronic spontaneous urticaria, hidradenitis suppurativa, and immune-mediated inflammatory disorders affecting skin, joints, and gastrointestinal tissues.
Hematology, Bleeding Disorders, and Cardiovascular Disease
Key hematology programs involve hemophilia A, hemophilia B, and primary immune thrombocytopenia, with attention to inherited bleeding disorders across pediatric and adult populations. Cardiovascular research includes heart failure, heart failure with preserved ejection fraction, and pulmonary arterial hypertension.
- Hemophilia A
- Hemophilia B
- Primary immune thrombocytopenia
- Heart failure with preserved ejection fraction
- Pulmonary arterial hypertension
Additional areas include transthyretin amyloidosis and transthyretin amyloid cardiomyopathy, reflecting interest in rare cardiovascular and systemic protein-aggregation disorders.
Infectious Diseases and Vaccines
Pfizer’s infectious disease portfolio includes studies in COVID-19, RSV infection, pneumococcal infections, group B streptococcus disease, and serious gram-negative bacterial infections. Research also covers hospital-acquired pneumonia, ventilator-associated pneumonia, sepsis, and complicated urinary tract infection.
- Respiratory syncytial virus
- Group B streptococcus
- Pneumococcal disease
- Gram-negative bacterial infections
- COVID-19
Vaccine-oriented work includes maternal and infant immunization studies, with emphasis on neonatal protection and prevention of invasive bacterial and respiratory infections.
Neurology, Metabolic, and Other Therapeutic Areas
Neurology studies focus on migraine, including chronic migraine, menstrual migraine, and migraine with or without aura, as well as prevention in adolescents. Metabolic and supportive-care research includes obesity, overweight management, type 2 diabetes mellitus, and cancer cachexia.
- Migraine disorders
- Obesity and overweight management
- Type 2 diabetes mellitus
- Cancer cachexia
- Growth hormone deficiency
Other areas of interest include duchenne muscular dystrophy, IgA nephropathy, obesity-related appetite loss, and erosive esophagitis, showing breadth across neuromuscular, renal, gastrointestinal, and metabolic conditions.
