This study is being conducted to evaluate the effectiveness and safety of a new treatment option for individuals with Metastatic Colorectal Cancer. This type of cancer occurs when cancer that started in the colon or rectum spreads to other parts of the body. The research compares two different treatment approaches. One approach uses the study drug PF-08634404 combined with chemotherapy, which is a type of treatment that uses strong medicines to kill fast-growing cancer cells. The chemotherapy used in this study consists of oxaliplatin, calcium folinate, and fluorouracil, which are administered through intravenous infusion, meaning they are delivered directly into a vein. The other approach uses bevacizumab combined with the same chemotherapy medicines.

Participants in the study will be assigned to one of the two treatment groups through a process called randomization, which is similar to drawing lots to decide which group a person joins. To ensure the results are unbiased, a double-blind method is used, meaning that neither the participants nor the researchers know which specific treatment is being given during the course of the study. The study will monitor how long the cancer remains stable and how long participants live to determine if the new combination is more effective than the current standard treatment.