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Mebeverine Hydrochloride

Clinical trials are studying Mebeverine Hydrochloride in people with irritable bowel syndrome. These studies aim to compare its effects with other treatments and measure symptom relief, pain, and quality of life. The main target population is adults with irritable bowel syndrome.

Table of contents

Trial overview

The available trial studies Mebeverine Hydrochloride in people with irritable bowel syndrome.[1] The study is titled as a multicenter randomized controlled clinical trial comparing ebastine and mebeverine as treatment of irritable bowel syndrome.[1]

This trial is authorised and includes 200 participants.[1] It is an interventional study, which means the researchers give a treatment and then measure the results.[1]

Study design and phase

The trial is a Phase 3 study.[1] Phase 3 studies usually test treatments in a larger group of people to compare how well they work in real patient care settings.

The study is randomized and controlled.[1] Randomized means people are assigned by chance to treatment groups, and controlled means the treatment is compared with another treatment or dummy treatment.[1]

The trial compares ebastine and Mebeverine Hydrochloride, with dummy treatments included in the study design.[1] The brief summary says the goal is a randomized superiority trial, which means the researchers want to find out whether one treatment works better than the other.[1]

Who is being studied

The target condition is irritable bowel syndrome, often called IBS.[1] IBS is a long-term bowel condition that can cause pain and other digestive symptoms.

The trial data do not give more detailed eligibility rules, such as age limits or symptom requirements.[1] Based on the source data, the main population is people with IBS.[1]

What is being measured

The main outcomes are abdominal pain intensity and global relief of symptoms.[1] Abdominal pain intensity means how strong the belly pain is, and global relief of symptoms means the overall sense of improvement.

The study also looks at quality of life and quality-adjusted life years.[1] Quality of life shows how the condition and treatment affect daily life, while quality-adjusted life years combine length of life and health quality into one measure.[1]

These outcomes show that the trial is not only asking whether symptoms improve, but also whether the treatment helps people feel and function better in daily life.[1]

Why this trial matters

This study is important because it compares Mebeverine Hydrochloride with another active treatment in a patient group that often has ongoing symptoms.[1] A head-to-head trial like this can help show which treatment gives better symptom relief and better overall patient benefit.[1]

Because the trial is authorised and already planned for 200 people, it represents a structured effort to evaluate treatment performance in IBS.[1] The source data do not report results yet, so the article can only describe the study plan, not the findings.[1]

Trial ID Phase Condition studied Status Enrollment
2022-501780-41-00 Phase 3 Irritable Bowel Syndrome Authorised 200

FAQ

  • What are clinical trials of Mebeverine Hydrochloride trying to find out? The trial is comparing Mebeverine Hydrochloride with ebastine to see which treatment works better for irritable bowel syndrome. It is looking at symptom relief, abdominal pain, and quality of life.
  • Who can take part in these trials? The target group is people with irritable bowel syndrome. The trial data do not list more detailed entry rules.
  • What phase is the Mebeverine Hydrochloride trial? The trial is in Phase 3. This means it is testing the treatment in a larger group of people to compare how well it works.
  • What outcomes are being measured? The main outcomes are abdominal pain intensity and global relief of symptoms. The study also looks at quality of life and quality-adjusted life years.
  • Is this trial testing Mebeverine Hydrochloride alone? No. It is a randomized comparison trial, so Mebeverine Hydrochloride is being compared with ebastine. Dummy treatments are also used to help make the comparison fair.

Ongoing Clinical Trials on Mebeverine Hydrochloride

  • Study Comparing Ebastine and Mebeverine for Treating Irritable Bowel Syndrome in Adults

    Recruiting

    3 1 1
    Investigated diseases:
    Investigated drugs:
    Belgium

Glossary

  • Irritable bowel syndrome: A long-term condition that affects the gut and can cause belly pain, bloating, and changes in bowel habits.
  • Randomized trial: A study where people are assigned by chance to different treatment groups. This helps make the comparison fair.
  • Controlled trial: A study that compares one treatment with another treatment or with a dummy treatment.
  • Phase 3: A later stage of clinical research done in a larger group of people to compare how well treatments work.
  • Interventional: A study in which researchers give a treatment and then measure the effects.
  • Primary outcome: The main result the researchers want to measure in a study.
  • Abdominal pain intensity: How strong the belly pain is. This is often measured to see whether treatment helps.
  • Global relief of symptoms: A broad measure of whether the person feels overall improvement in their symptoms.
  • Quality of life: How a health problem and its treatment affect daily life and well-being.
  • Quality-adjusted life years: A way to measure both how long people live and how well they live during that time.
  • Dummy treatment: A treatment made to look like the real one but without the active study drug, used for fair comparison.

References

  1. https://clinicaltrials.gov/study/2022-501780-41-00