Haematologic Malignancies and Blood Disorders
Multiple myeloma, relapsed or refractory myeloma, chronic lymphocytic leukemia, small lymphocytic lymphoma, non-Hodgkin lymphoma, acute myeloid leukemia, myelodysplastic neoplasms, and AL amyloidosis are prominent areas of interest, alongside studies in mantle cell lymphoma and other B-cell malignancies.
- Multiple myeloma and plasma cell disorders
- B-cell non-Hodgkin lymphoma and CLL/SLL
- Acute leukemia and myelodysplastic neoplasms
Research also extends to warm autoimmune hemolytic anemia and other haematology-focused conditions.
Oncology in Solid Tumours
The sponsor funds research in non-small cell lung cancer, prostate cancer, urothelial cancer, bladder cancer, colorectal cancer, head and neck squamous cell carcinoma, and other advanced solid tumors, including metastatic and recurrent disease settings.
- Non-small cell lung cancer
- Prostate cancer
- Urothelial and bladder cancers
Additional activity includes studies in gastric cancer, advanced solid tumors, and biomarker-defined tumour populations.
Immune-Mediated and Inflammatory Diseases
Clinical research includes psoriasis, psoriatic arthritis, ulcerative colitis, Crohn’s disease, rheumatoid arthritis, systemic lupus erythematosus, Sjögren’s disease, and idiopathic inflammatory myopathies, with both adult and paediatric populations represented.
- Psoriasis and psoriatic arthritis
- Inflammatory bowel disease
- Systemic autoimmune and rheumatologic disease
Work also covers atopic dermatitis, asthma, and chronic inflammatory demyelinating polyneuropathy.
Neurology, Psychiatry, and Ophthalmology
Janssen Cilag International supports studies in Alzheimer’s disease, major depressive disorder, bipolar depression, myasthenia gravis, chronic inflammatory neuropathies, and stroke prevention, together with ophthalmic research in geographic atrophy and X-linked retinitis pigmentosa.
- Alzheimer’s disease and cognitive decline
- Depression and related mood disorders
- Neuromuscular and retinal disorders
Further interest includes acute suicidal ideation and healthy volunteer studies supporting neurological and psychiatric development.
Cardiovascular, Maternal, Infectious, and Metabolic Conditions
The portfolio also includes atrial fibrillation, acute coronary syndrome, atherothrombotic and thromboembolic disorders, acute ischemic stroke, and metastatic castration-sensitive prostate cancer with cardiovascular-relevant treatment questions, as well as maternal-fetal conditions such as hemolytic disease of the fetus and newborn and fetal and neonatal alloimmune thrombocytopenia.
- Atrial fibrillation and ischemic stroke
- Maternal-fetal haematology
- Hepatitis B and hepatitis D co-infection
Research activity also includes tuberculosis, renal impairment, and healthy adult participant studies relevant to drug disposition and clinical use.
