Breast cancer research
Clinical activity includes early breast cancer, luminal B breast cancer, HER2-positive breast carcinoma, and triple-negative breast cancer, with attention to treatment selection, tumour profiling, and surgical planning.
- HER2 molecular imaging
- Antibody-drug conjugate sequencing
- Breast-conserving surgery margin assessment
- Neoadjuvant and perioperative strategies
Research also covers imaging-guided decision-making, intraoperative assessment, and systemic treatment approaches in both hormone receptor-positive and aggressive breast cancer subtypes.
Rectal cancer and colorectal oncology
Trials focus on locally advanced rectal cancer in older adults, with interest in balancing efficacy, safety, and treatment burden across multimodal care pathways.
- Short-course radiotherapy
- Long-course chemoradiotherapy
- Total neoadjuvant therapy
- Immunotherapy combinations
Work in this area includes perioperative treatment strategies and biomarker-driven approaches for microsatellite stable and mismatch repair-proficient tumours.
Head and neck cancer and swallowing outcomes
Research includes oropharyngeal cancer and supportive care after chemoradiotherapy, with emphasis on swallowing function and patient-reported quality of life.
- Dysphagia assessment
- Percutaneous endoscopic gastrostomy placement
- Supportive care during radiotherapy
- Patient-reported outcomes
These studies address nutritional support, functional recovery, and symptom management in patients receiving definitive treatment for advanced disease.
Immuno-oncology and tumour biomarkers
Several trials examine checkpoint inhibitors, immune-related toxicities, and tumour-associated markers across advanced solid tumours, including breast and colorectal cancers.
- CD73-targeted therapy
- Durvalumab-based combinations
- Immune biomarker discovery
- HER2 expression heterogeneity
Research also includes molecular characterization of metastatic disease and biomarker exploration to refine treatment selection in advanced solid tumours.
Palliative care and end-of-life support
Clinical interest extends to palliative care and best supportive care, with attention to symptom relief and quality of life in patients without remaining active treatment options.
- Quality of life evaluation
- Testosterone supplementation
- Supportive symptom management
- Androgen deficiency
This area includes supportive interventions aimed at physical comfort and functional well-being in advanced illness.
