Thoracic and Gastroesophageal Oncology
Heidelberg University supports clinical research in advanced solid tumours, with a strong focus on non-small-cell lung cancer and adenocarcinoma of the gastroesophageal junction. Its funded studies address treatment selection in stage IV NSCLC with atypical EGFR mutations and perioperative strategies for resectable upper gastrointestinal cancer.
- Osimertinib and chemotherapy in advanced NSCLC
- EGFR-mutated lung cancer
- Gastroesophageal junction adenocarcinoma
- Perioperative radiochemotherapy
The oncology portfolio also includes treatment planning around surgical outcomes, progression-free survival, and disease control in locally advanced digestive tract malignancies.
Myeloid Malignancies and Treatment-Free Remission
The sponsor is active in chronic myeloid leukemia and related myeloid neoplasms, including research on myelodysplastic neoplasms and chronic myelomonocytic leukemia. A key interest is the management of long-term tyrosine kinase inhibitor therapy and the durability of remission after treatment discontinuation.
- Chronic myeloid leukemia in chronic phase
- Ponatinib and nilotinib treatment strategies
- Treatment-free remission
- Myelodysplastic neoplasms and CMML
These studies concentrate on molecular response states such as MR4 and MMR, as well as the persistence of remission after repeated attempts to stop therapy.
Colorectal Cancer and Surgical Oncology
Clinical research also covers locally advanced rectal cancer, with attention to the sequencing of chemotherapy and surgery in patients at risk for local recurrence. The funded work examines approaches intended to improve oncologic control in resectable disease.
- Locally advanced rectal cancer
- FOLFOX-based treatment
- Preoperative and postoperative chemotherapy
- Disease-free survival
This area reflects interest in colorectal tumour management, surgical completeness, and recurrence prevention after curative-intent treatment.
Cerebrovascular Disease and Aneurysm Risk Management
Heidelberg University funds research in unruptured intracranial aneurysm care, focusing on strategies to reduce the risk of aneurysm rupture or growth. The clinical interest lies in preventive management of vascular lesions before haemorrhagic complications occur.
- Intradural saccular aneurysm
- Intracranial aneurysm surveillance
- Blood pressure management
- Aspirin-based risk reduction
The research domain combines vascular neurology and preventive cerebrovascular care in patients with unruptured aneurysmal disease.
