This study focuses on treating adenocarcinoma of the gastroesophageal junction, which is cancer occurring where the esophagus (food pipe) meets the stomach. The treatment involves a combination of chemotherapy medications including fluorouracil, docetaxel, oxaliplatin, and calcium folinate, which are given through an intravenous line directly into the bloodstream.
The purpose of this research is to determine if adding radiation therapy to chemotherapy before surgery works better than using chemotherapy alone before and after surgery for treating this type of cancer. The study compares these two different approaches to find out which one is more effective at preventing the cancer from returning.
Patients who participate in the study will receive treatment for approximately 33 weeks. During this time, they will receive either chemotherapy alone or chemotherapy combined with radiation therapy, followed by surgery to remove the cancer. After surgery, doctors will monitor the patients’ progress to see how well the treatment worked and check for any side effects.
Germany 