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Ly3556050

Clinical trials are studying Ly3556050 in adults with diabetic peripheral neuropathic pain. These studies aim to see whether it can reduce pain better than placebo and measure changes in pain scores over time. The trial data shown here focuses on adults with diabetic peripheral neuropathy in a Phase 2 study.

Table of Contents

Trial overview

This clinical trial studied Ly3556050 in adults with diabetic peripheral neuropathic pain.[1] The study was interventional, which means researchers gave a study treatment and then measured the results.[1]

Who the trial studies

The target population was adult participants with diabetic peripheral neuropathy, a form of nerve damage linked to diabetes.[1] The study title also describes the condition as diabetic peripheral neuropathic pain, which is pain caused by that nerve damage.[1]

Treatments and comparison

The trial compared Ly3556050 with placebo, which is a look-alike treatment without the active study drug.[1] The intervention list shows Ly3556050 and placebo to match Ly3556050, so the study was designed to see whether Ly3556050 performed better than placebo for pain relief.[1]

Trial phase and design

This was a Phase 2 study.[1] Phase 2 trials usually look more closely at whether a treatment may work while continuing to collect safety information, although the source here mainly states the phase and the study goal.[1]

The trial was planned as a study with 410 participants.[1] That size suggests the researchers wanted enough people to compare pain results between treatment groups.

Main outcome measured

The primary outcome was the Mean Change from Baseline for Average Pain Intensity Numeric Rating Scale (API-NRS).[1] In simple terms, this means the study measured how much the pain score changed from the start of the trial to later time points.[1] The brief study summary says the goal was to show that at least one dose of Ly3556050 was better than placebo in pain intensity.[1]

What completed means

The trial status is completed.[1] This means the study has finished and the planned data collection is done.[1]

Trial ID Phase Condition studied Status Enrollment
2023-506127-29-00 Phase 2 Diabetic Peripheral Neuropathy / Diabetic Peripheral Neuropathic Pain Completed 410

FAQ

  • What is being studied in Ly3556050 trials? The trial is studying whether Ly3556050 can lower pain in adults with diabetic peripheral neuropathic pain. It compares Ly3556050 with placebo, which is a look-alike treatment with no active study drug.
  • Who can take part in the trial? The study is for adult participants with diabetic peripheral neuropathic pain. The trial data does not give more detailed joining rules, so exact eligibility would depend on the study criteria.
  • What phase is the Ly3556050 trial? The trial is Phase 2. Phase 2 studies usually look more closely at whether a treatment works and continue checking safety in a larger group than early studies.
  • What outcome is the trial measuring? The main outcome is the mean change from baseline in Average Pain Intensity Numeric Rating Scale, or API-NRS. This means the study measures how pain scores change from the start of the trial.
  • What is the status of the Ly3556050 trial? The trial is completed. This means the study has finished collecting the planned information.

Ongoing Clinical Trials on Ly3556050

  • Study of LY3556050 for Adults with Diabetic Peripheral Neuropathy Pain

    Not recruiting

    2 1
    Investigated diseases:
    Investigated drugs:
    Czechia Poland

Glossary

  • Adult participants: People who are 18 years old or older and can join a study if they meet the trial rules.
  • Diabetic peripheral neuropathic pain: Pain caused by nerve damage related to diabetes, often felt in the feet or legs.
  • Diabetic peripheral neuropathy: Nerve damage in the outer parts of the body, usually linked to diabetes.
  • Placebo: A look-alike treatment used in studies to compare with the study drug. It does not contain the active study treatment.
  • Phase 2: A middle stage of clinical research that checks whether a treatment may work and continues to watch safety.
  • Interventional study: A study where researchers give a treatment and then measure what happens.
  • Average Pain Intensity Numeric Rating Scale (API-NRS): A pain score used to measure how strong pain feels, usually on a number scale.
  • Baseline: The starting point before treatment begins, used for comparison later.
  • Enrollment: The number of people planned or included in a study.
  • Completed: The study has finished as planned and no longer accepts participants.

References

  1. https://clinicaltrials.gov/study/2023-506127-29-00