Akershus University Hospital

Pain Management and Analgesia

The hospital demonstrates substantial expertise in pain medicine and analgesic interventions across diverse clinical scenarios. Research activities encompass the evaluation of opioid analgesics including oxycodone and morphine for managing various pain conditions. Investigations extend to breakthrough pain management in patients with chronic non-malignant pain, as well as acute pain control following surgical procedures.

  • Opioid therapy optimisation
  • Postoperative pain control
  • Chronic pain syndromes
  • Breakthrough pain management

The institution pursues comparative studies of analgesic efficacy and explores alternative approaches to pain relief in both surgical and non-surgical patient populations, with particular attention to opioid-related adverse effects and treatment safety profiles.

Orthopaedic Surgery and Rehabilitation

Significant research efforts focus on orthopaedic surgical interventions and associated recovery processes. The hospital investigates outcomes following total hip arthroplasty and total knee arthroplasty, examining both immediate postoperative care and long-term functional recovery. Studies address surgical site complications, wound healing, and optimal strategies for perioperative care.

  • Joint replacement surgery
  • Postoperative recovery protocols
  • Surgical wound management
  • Functional rehabilitation outcomes

Research encompasses the evaluation of different surgical approaches and postoperative management strategies, including investigations into negative pressure wound therapy and methods to prevent surgical site infections in arthroplasty patients.

Gastrointestinal Disorders and Therapeutics

The institution maintains active research programmes addressing gastrointestinal motility disorders and related symptomatology. Particular emphasis is placed on opioid-induced constipation as a significant clinical challenge, with investigations into both preventive strategies and therapeutic interventions. Studies examine the impact of various pharmaceutical agents on bowel function and gastrointestinal transit.

  • Opioid-induced bowel dysfunction
  • Constipation management
  • Gastrointestinal motility assessment
  • Laxative therapy evaluation

Research activities incorporate assessment tools for measuring bowel function parameters and quality of life impacts associated with gastrointestinal adverse effects in patients receiving long-term medication therapies.

Dermatological Conditions and Wound Care

The hospital conducts focused investigations into dermatological manifestations associated with pharmacological treatments, particularly opioid-induced pruritus. Research examines the mechanisms, prevalence, and management strategies for drug-induced itching and related skin symptoms. Additional work addresses wound healing processes in surgical contexts.

  • Medication-induced pruritus
  • Dermatological adverse reactions
  • Surgical wound healing
  • Skin integrity assessment

Studies incorporate patient-reported outcome measures to evaluate the burden of cutaneous side effects and investigate interventions aimed at improving skin-related quality of life in patients undergoing various therapeutic regimens.

Perioperative Medicine and Surgical Outcomes

Research activities encompass comprehensive evaluation of perioperative care pathways and their influence on surgical outcomes. The hospital investigates strategies for optimising postoperative recovery, including assessment of different anaesthetic techniques and multimodal analgesia approaches. Studies address complications such as postoperative nausea and vomiting, wound dehiscence, and factors affecting patient mobilisation.

  • Enhanced recovery protocols
  • Postoperative complication prevention
  • Surgical outcome optimisation
  • Patient mobilisation strategies

The institution pursues evidence-based approaches to improve surgical care quality, examining both clinical outcomes and patient-centred measures including functional recovery and quality of life following major surgical procedures.

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Matched clinical trials

  • Comparison of Gentamicin with Narrow-Spectrum Antibiotics versus Broad-Spectrum Antibiotics in Adult Patients with Early Sepsis

    Recruiting

    3 1 1 1
    Investigated diseases:
    Norway
  • Study on Clopidogrel and Dalteparin Sodium for Preventing Blood Clots in Pancreatic Cancer Patients

    Recruiting

    3 1 1 1
    Investigated diseases:
    Norway
  • Study on Chiropractic Therapy and Ibuprofen for Acute Neck Pain in Adults

    Recruiting

    3 1 1
    Investigated diseases:
    Investigated drugs:
    Norway
  • Study on Stopping Antibiotics in Adults with Viral Respiratory Infections Using Tetracyclines and Other Antibiotics

    Recruiting

    3 1 1 1
    Investigated diseases:
    Norway
  • Effect of Dexmedetomidine vs Sodium Chloride on Emergence Delirium in Children Aged 1‑7 Years Undergoing Adenotonsillectomy

    Not yet recruiting

    3 1 1
    Investigated diseases:
    Norway
  • Study on Midazolam Hydrochloride: Comparing Subcutaneous and Intravenous Use in Adults with Terminal Illness in Palliative Care

    Not yet recruiting

    2 1 1 1
    Investigated diseases:
    Investigated drugs:
    Norway