Study on Chiropractic Therapy and Ibuprofen for Acute Neck Pain in Adults

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What is this study about?

This clinical trial is focused on studying the effects of treatments for acute neck pain. The study will explore the effectiveness of two main treatments: Chiropractic Spinal Manipulative Therapy (CSMT) and a medication called Ibuprofen, which is commonly used to relieve pain and reduce inflammation. Additionally, the study will include a comparison with a placebo treatment. The purpose of the study is to investigate how these treatments affect the intensity of neck pain during the treatment period.

Participants in the study will be divided into four groups. One group will receive CSMT, another will receive a sham or fake version of CSMT, the third group will take Ibuprofen, and the fourth group will receive a placebo. The study will monitor changes in pain levels from the start of the study to two weeks later. The study will also look at changes in pain over several days during the treatment period and at various points after the treatment has ended.

The study aims to provide insights into which treatment is most effective in reducing pain for individuals experiencing acute neck pain. By comparing the different groups, researchers hope to better understand the benefits and effectiveness of CSMT and Ibuprofen in managing this condition.

1 joining the study

Upon joining the study, participants are assigned to one of four groups. Each group receives a different treatment for acute neck pain.

The treatments include chiropractic spinal manipulative therapy (CSMT), sham manipulation, ibuprofen medication, or placebo medication.

2 treatment administration

Participants in the ibuprofen group receive 600 mg film-coated tablets. The medication is taken orally.

The frequency and duration of ibuprofen administration are determined by the study protocol.

3 monitoring and assessment

Participants’ pain intensity is measured using a numeric rating scale (NRS) from 0 to 10.

The primary assessment occurs from baseline to day 14, with additional assessments on days 2 to 13, and post-treatment on days 7, 28, 56, 84, and 168.

4 completion of the study

The study is estimated to conclude by December 31, 2024.

Participants’ data will contribute to understanding the efficacy of the treatments for acute neck pain.

Who Can Join the Study?

Participants must be between 18 and 59 years old.
Participants should have acute non-radicular neck pain, which means neck pain that does not spread to other parts of the body, and is classified as grade 1 or 2 by a specific task force on neck pain.
The current episode of neck pain must have started within the last 2 weeks before the first chiropractic visit.
The pain intensity should be moderate, severe, or very severe, which means a score of 4 or higher on a scale from 0 to 10.
Participants should have been pain-free for at least four weeks in a row before the current episode of neck pain.
Participants should not have been treated by a chiropractor in the past 3 months.
Participants must agree not to seek other manual (hands-on) or drug treatments for their neck pain during the study period.
Participants must be non-pregnant women. If there is any doubt, a negative pregnancy test is required before joining the study.

Who Cannot Join the Study?

Patients who are under 18 years old cannot participate.
Patients who have any other serious health conditions that might interfere with the study cannot participate.
Patients who are pregnant or breastfeeding cannot participate.
Patients who have had recent surgery on the neck cannot participate.
Patients who are currently taking other medications that might affect the study cannot participate.
Patients who have a history of allergic reactions to the study medications cannot participate.
Patients who are unable to follow the study procedures cannot participate.

Where you can join this trial?

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Other Sites

Site Name	City	Country
Fysioterapicenteret, Hønefoss	Hønefoss	Norfolk Island
Altlrctlydswwo Brdnej Ax	Bergen	Norway
Kwcbhcg Nlkk	Leknes	Norway
Abplstjkzrjuugp Oyre	Oslo	Norway
Kbmjuiaibhbnckurire i Krqemhzvvhkn	Kristiansund	Norway
Nhmri Dkwnmcy	Drammen	Norway
Ncpgv Jkxzxnol Aj	Jessheim	Norway
Tpcinwbs kswxjoolfflkqmprkr	Tonsberg	Norway
Farbuhv Kwgtupwkyouf	Tertnes	Norway
Dzu Klryqrjddhy	Drammen	Norway
Fgsbirqbifi kauxssmarmxscvieap	Flekkefjord	Norway
Kmrvhrn Fepbpvm	Oslo	Norway
Shijprf Kxyuxkonxln	Sandane	Norway
Kgrsvytfkganyqrsyn Sivoquj	Oslo	Norway
Bhgyp knpqoxczqmofmhaugi or fetmneulydlt Slunb aobdcbuy	Skien	Norway
Kngpujt Ofijbli	Tananger	Norway
Nmuqx	Lorenskog	Norway
Nohxm Hoaxvmr	Harstad	Norway
Avlfy Hnrfjq Htisoqkz	Hønefoss	Norway
Njofm Nhfwzbvi	Nittedal	Norway
Fucjkltsfedggtq Øiyqf	Oslo	Norway
Svefcnirfg Kcdaxiiaanva	Vik i Sogn	Norway
Mouelz Klpddstylqbzjkwlilp Mhxeu	Moelv	Norway
Hoqcqqqn Kayfjpobxycv &kzgc Hpzrs	Borgenhaugen	Norway
Kindutd Vweij Ag	Vadsø	Norway
Hrdgr i Squqcwg (aemex	Oslo	Norway
Bdb Bstdf Kdxsgkkpabtuhkigis	Hokkesund	Norway
Fbytbtb kqeouepgoyeecenol	Fetsund	Norway
Kbrxffl Vooih Ae	Oslo	Norway
Krkshwozcenjappbyljr Fkxmrfyi	Finnsnes	Norway
Iebjesvr Ifgtejzxlmpaqxs Lcnkxszl	Levanger	Norway
Sqcrp Hhxec	Oslo	Norway
Kmesbryrvmp kmqkglubi Hczpab	Halden	Norway
Hktzf i fmkeel Gakhhryu	Grimstad	Norway
Fevjl Htyxb &ipzn Tpfylhf	Sandefjord	Norway
Kusydpyhfxr Kazl Bycphohs Bxrdh Kujfuvvha	Kolvereid	Norway
Rjjiftihtiliul	Randaberg	Norway
Kkflxlm Mvrbpcinem Sgsenhd Sgerupkw Sgknqaq 2 eooz	Sofiemyr	Norway
Askrugut Ubenouuivc Hfjjldxz	Lorenskog	Norway

Trial status

Country	Status	Recruitment Start
Norway	Recruiting	01.09.2022

Trial locations

Investigated drugs:

Chiropractic Spinal Manipulative Therapy (CSMT) is a hands-on treatment where a chiropractor uses their hands to apply a controlled force to a joint of the spine. The goal is to improve spinal motion and improve the body’s physical function. In this trial, CSMT is being tested to see how effective it is in reducing the intensity of acute neck pain.

NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) are a class of medications that reduce inflammation, pain, and fever. They are commonly used to relieve pain from various conditions, including acute neck pain. In this trial, NSAIDs are being evaluated for their effectiveness in decreasing the intensity of neck pain during the treatment period.

Investigated diseases:

Neck pain

Acute Neck Pain – Acute neck pain is a sudden onset of discomfort or pain in the neck area, often resulting from muscle strain, poor posture, or injury. It can cause stiffness, limited range of motion, and tenderness in the neck muscles. The pain may radiate to the shoulders or upper back and can be accompanied by headaches. Typically, acute neck pain develops quickly and can last from a few days to a few weeks. It may be exacerbated by certain movements or positions, such as turning the head or looking down for extended periods. The condition is common and can affect individuals of all ages.

Trial ID:

2023-509624-17-00

NCT ID:

NCT05374057

Trial Phase:

Therapeutic confirmatory (Phase III)

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Study on Chiropractic Therapy and Ibuprofen for Acute Neck Pain in Adults

What is this study about?

Who Can Join the Study?

Who Cannot Join the Study?