Analytical, Diagnostic and Therapeutic Techniques and Equipment – Diagnosis
The Klinikum der Technischen Universität München employs advanced diagnostic platforms to improve early detection of complex disorders, ranging from oncology biomarkers to cardiac imaging.
- High‑resolution MRI for brain tumor assessment
- Multiplex PCR panels for infectious disease screening
- Quantitative PET imaging for treatment response
Over 300 active studies leverage these tools, supporting a multidisciplinary approach to patient care.
Analytical, Diagnostic and Therapeutic Techniques and Equipment – Investigative Techniques
Researchers explore novel investigative methods, such as cellular profiling and fluid biomarkers, to unravel disease mechanisms.
- Single‑cell RNA sequencing in hematologic malignancies
- Circulating tumor DNA analysis for minimal residual disease
- Metabolomic profiling in metabolic syndrome
The department collaborates with 151 investigators to integrate these techniques across therapeutic areas.
Analytical, Diagnostic and Therapeutic Techniques and Equipment – Therapeutics
The site develops and tests innovative therapeutic technologies, including targeted drug delivery systems and immunomodulatory devices.
- Nanoparticle‑based chemotherapy for solid tumors
- Radio‑frequency ablation for liver metastases
- Device‑assisted neuromodulation for chronic pain
These efforts aim to translate cutting‑edge tools into safer, more effective patient treatments.
Diseases – Bacterial Infections and Mycoses
Clinical trials address resistant bacterial and fungal pathogens, evaluating new antimicrobial agents and stewardship strategies.
- Multidrug‑resistant Gram‑negative infections
- Invasive candidiasis in immunocompromised patients
- Clostridioides difficile recurrence prevention
The program supports antimicrobial innovation while safeguarding patient safety.
Diseases – Cardiovascular Diseases
Studies focus on heart failure, cardiomyopathy, and arrhythmias, testing novel pharmacologic and device‑based therapies.
- NYHA Class III heart failure with preserved ejection fraction
- Non‑ischemic cardiomyopathy management
- Implantable cardioverter‑defibrillator optimization
Research aims to improve survival and quality of life for patients with advanced cardiac conditions.
Diseases – Congenital, Hereditary, and Neonatal Diseases and Abnormalities
The department investigates genetic and developmental disorders, exploring gene‑editing and early‑intervention therapies.
- Autosomal dominant polycystic kidney disease
- Congenital hemophilia treatment advances
- Neonatal metabolic screening improvements
Collaborative trials aim to translate precision medicine to vulnerable patient populations.
Diseases – Digestive System Diseases
Research targets inflammatory bowel disease, liver disorders, and gastrointestinal cancers, evaluating biologics and endoscopic interventions.
- Moderate to severe Crohn’s disease
- Non‑alcoholic steatohepatitis (NASH) therapies
- FGFR2b‑positive gastroesophageal adenocarcinoma
The goal is to enhance disease control and reduce invasive procedures.
Diseases – Eye Diseases
Clinical programs assess treatments for retinal degeneration, macular edema, and neovascular conditions.
- Diabetic macular edema management
- Age‑related macular degeneration (dry and neovascular)
- Choroidal neovascularization secondary to myopia
Innovative ocular therapies aim to preserve vision and reduce disease progression.
Diseases – Female Urogenital Diseases and Pregnancy Complications
Trials explore hormonal, oncologic, and obstetric conditions, testing targeted agents and supportive care measures.
- Hormone‑receptor positive breast cancer in pregnancy
- Severe pre‑eclampsia prevention strategies
- Recurrent urinary tract infections in women
Research seeks to balance maternal health with fetal safety.
Diseases – Hemic and Lymphatic Diseases
The site conducts extensive hematology trials, focusing on leukemias, lymphomas, and myeloproliferative disorders.
- Relapsed/refractory acute myeloid leukemia
- Chronic lymphocytic leukemia with novel BTK inhibitors
- Myelodysplastic syndrome with luspatercept
These studies aim to improve remission rates and long‑term survival.
Diseases – Hormonal diseases
Investigations include endocrine disorders such as diabetes, thyroid disease, and adrenal insufficiency, evaluating new drug classes and lifestyle interventions.
- Prediabetes management with SGLT2 inhibitors
- Autoimmune thyroiditis treatment trials
- Adrenal insufficiency hormone replacement optimization
The emphasis is on metabolic control and reducing complications.
Diseases – Immune System Diseases
Studies address autoimmune and immunodeficiency conditions, testing biologics, cell therapies, and vaccination strategies.
- Generalized myasthenia gravis with anti‑AChR antibodies
- Chronic spontaneous urticaria with novel monoclonal antibodies
- Acquired angioedema due to C1‑inhibitor deficiency
Research aims to modulate immune pathways for durable symptom relief.
Diseases – Male Urogenital Diseases
Clinical work focuses on prostate cancer and benign prostatic hyperplasia, evaluating hormonal and targeted therapies.
- Metastatic castration‑resistant prostate cancer
- High‑risk recurrent prostate cancer post‑prostatectomy
- PSMA‑targeted radioligand therapy trials
The aim is to extend survival while maintaining quality of life.
Diseases – Musculoskeletal Diseases
Research includes osteoarthritis, rheumatoid arthritis, and rare connective‑tissue disorders, testing disease‑modifying agents.
- Moderate to severe plaque psoriasis as a systemic musculoskeletal condition
- Hidradenitis suppurativa treatment with biologics
- Fibromyalgia symptom management trials
Innovative therapies aim to reduce pain and improve joint function.
Diseases – Neoplasms
The oncology portfolio spans solid tumors and hematologic malignancies, testing immunotherapies, targeted agents, and combination regimens.
- Advanced clear cell renal cell carcinoma
- HER2‑positive gastric and gastroesophageal junction adenocarcinoma
- Triple‑negative breast cancer with PARP inhibitors
- Small‑cell lung cancer radioligand imaging studies
With over 150 active cancer trials, the site strives to deliver personalized oncology care.
Diseases – Nervous System Diseases
Trials target neurodegenerative and neuroinflammatory disorders, assessing disease‑modifying drugs and symptomatic therapies.
- Alzheimer’s disease with anti‑amyloid antibodies
- Amyotrophic lateral sclerosis (ALS) novel small molecules
- Multiple sclerosis progressive forms
Efforts focus on slowing progression and preserving neurological function.
Diseases – Nutritional and Metabolic Diseases
Research addresses obesity, metabolic syndrome, and micronutrient deficiencies, testing pharmacologic and lifestyle interventions.
- Severe vitamin D deficiency in critically ill adults
- Obesity‑related heart failure with preserved ejection fraction
- Type 1 diabetes immunotherapy trials
The objective is to improve metabolic health and reduce cardiovascular risk.
Diseases – Otorhinolaryngologic Diseases
Clinical work includes chronic sinus disease, hearing loss, and rare ear disorders, evaluating pharmacologic and procedural options.
- Idiopathic sudden sensorineural hearing loss
- Chronic rhinosinusitis with nasal polyps
- Autoimmune inner ear disease therapies
Studies aim to restore function and reduce disease burden.
Diseases – Respiratory Tract Diseases
The department conducts trials on chronic lung conditions and acute infections, testing inhaled therapies and antiviral strategies.
- Chronic obstructive pulmonary disease (COPD) exacerbation prevention
- COVID‑19 antiviral treatment in hospitalized patients
- Interstitial lung disease associated with autoimmune disorders
Efforts focus on improving respiratory function and reducing hospitalizations.
Diseases – Skin and Connective Tissue Diseases
Studies explore inflammatory skin disorders and rare dermatoses, evaluating biologics and small‑molecule inhibitors.
- Moderate to severe atopic dermatitis with dupilumab
- Chronic spontaneous urticaria refractory to antihistamines
- Vitiligo treatment with JAK inhibitors
The aim is to achieve durable skin clearance and improve patient quality of life.
Diseases – Virus Diseases
Clinical investigations target viral infections such as HIV, hepatitis, and emerging pathogens, testing novel antivirals and vaccine candidates.
- HIV‑1 suppression with bictegravir/lenacapavir fixed‑dose combination
- Chronic hepatitis B functional cure strategies
- CMV/EBV reactivation management post‑stem cell transplant
Research seeks to achieve viral control and prevent disease progression.
Phenomena and Processes – Digestive System and Oral Physiological Phenomena
Investigations examine gastric motility, microbiome dynamics, and oral health processes, linking them to systemic disease.
- Gastroparesis in diabetic patients
- Microbiome modulation in inflammatory bowel disease
- Oral mucosal healing after endoscopic submucosal dissection
Understanding these phenomena supports targeted therapeutic development.
Phenomena and Processes – Genetic Phenomena
The site leverages genomic sequencing to identify driver mutations and hereditary risk factors across disease spectra.
- FGFR2b overexpression in gastric cancers
- BRCA1/2 mutations in breast and ovarian cancer
- KRAS G12C mutation targeting in colorectal cancer
Genetic insights guide precision medicine approaches in clinical trials.
Phenomena and Processes – Immune system processes
Research focuses on cytokine signaling, checkpoint pathways, and cellular immunity to develop next‑generation immunotherapies.
- PD‑L1 inhibition combined with chemotherapy in solid tumors
- CAR‑T cell persistence monitoring after infusion
- JAK‑STAT pathway modulation in autoimmune disease
These studies aim to harness or temper immune responses for therapeutic benefit.
Phenomena and Processes – Ocular Physiological Phenomena
Investigations assess retinal blood flow, intra‑ocular pressure dynamics, and visual acuity changes under novel treatments.
- Carbon dioxide‑based contrast sparing in peripheral vascular imaging
- Automated retinal imaging biomarkers for diabetic retinopathy
- Neuroprotective agents for age‑related macular degeneration
Findings aim to refine diagnostic accuracy and therapeutic monitoring.
Phenomena and Processes – Reproductive and Urinary Physiological Phenomena
Studies evaluate hormonal cycles, renal filtration, and urinary tract dynamics, linking them to disease states and treatment outcomes.
- Renal perfusion changes during heart failure therapy
- Uterine artery embolization effects on fibroid symptom relief
- Bladder compliance assessment in interstitial cystitis
The goal is to improve organ‑specific interventions and patient comfort.
Psychiatry and Psychology – Mental Disorders
Clinical programs address neuropsychiatric illnesses, testing novel psychopharmacologic agents and digital therapeutics.
- Agitation management in Alzheimer’s disease dementia
- Depression in patients with chronic inflammatory disease
- Early intervention in prodromal Parkinson’s disease
Research seeks to alleviate symptoms and enhance cognitive function.
