Centro Hospitalar Universitario De Santo Antonio E.P.E.

Largo Professor Abel Salazar, Porto, 4050-011, Portugal

Nervous System Diseases

The Centro Hospitalar Universitario De Santo Antonio pediatric neurology team is studying Migraine in children, testing a new biologic therapy to reduce the number of migraine days and improve daily functioning.

Evaluation of a novel preventive treatment
Assessment of attack frequency reduction
Monitoring safety and tolerability in young patients
Impact on quality of life and school attendance
Long‑term follow‑up of therapeutic outcomes

With 73 investigators involved, the site in Porto, Portugal, is leading five independent trials aimed at advancing care for pediatric migraine sufferers.

A study comparing macrogol 3350 combination and sodium picosulfate for bowel cleansing before colonoscopy in children and teenagers with colonic disease

Recruiting

3 1 1 1
Investigated Drugs:
+3
A Study Comparing Empasiprubart Versus Intravenous Immunoglobulin in Adults With Chronic Inflammatory Demyelinating Polyneuropathy

Recruiting

3 1 1 1
Investigated Drugs:
- Empasiprubart
- Human Normal Immunoglobulin (Iv)
+13
A study of finerenone with standard treatment for children and young adults from birth to 18 years with heart failure and left ventricular systolic dysfunction

Recruiting

3 1 1
Investigated Diseases:
- Left ventricular dysfunction
- Cardiac failure
Investigated Drugs:
- Finerenone
+7
A study testing how well patiromer lowers high potassium levels in the blood in children under 12 years of age with hyperkalemia

Recruiting

2 1 1
Investigated Diseases:
- Hyperkalaemia
Investigated Drugs:
- Patiromer
+5
Study of icotrokinra for adults with moderately to severely active Crohn’s disease

Recruiting

4 1
Investigated Diseases:
- Crohn’s disease
Investigated Drugs:
- ICOTROKINRA
+7
Testing icotrokinra compared to placebo for adults and adolescents with moderately to severely active ulcerative colitis

Recruiting

3 1
Investigated Diseases:
- Colitis ulcerative
Investigated Drugs:
- ICOTROKINRA
+7
A study testing VH4524184 with emtricitabine and tenofovir alafenamide compared to dolutegravir and lamivudine in adults with HIV-1 who have not received treatment before

Recruiting

2 1 1 1
Investigated Diseases:
- HIV infection
Investigated Drugs:
+1
A study to test how well empagliflozin works and how safe it is for children and teenagers with chronic kidney disease

Recruiting

3 1 1
Investigated Diseases:
- Chronic kidney disease
Investigated Drugs:
- Empagliflozin
+4
Study of KarXT (trospium chloride and xanomeline tartrate) and KarX-EC (xanomeline tartrate) for cognitive impairment in mild to moderate Alzheimer’s disease

Recruiting

3 1
Investigated Diseases:
- Dementia Alzheimer’s type
Investigated Drugs:
- Trospium Chloride
- Xanomeline Tartrate
+4
Study of trastuzumab deruxtecan with pembrolizumab versus platinum chemotherapy with pembrolizumab for patients with untreated HER2-positive non-small cell lung cancer

Recruiting

3 1 1 1
Investigated Diseases:
- HER2 mutant non-small cell lung cancer
- Non-small cell lung cancer
Investigated Drugs:
+3