Trastuzumab Deruxtecan is a targeted therapy medication used to treat certain types of cancer. It combines an antibody that targets HER2-positive cancer cells with a chemotherapy drug. This medication is designed to deliver the chemotherapy directly to cancer cells while potentially limiting damage to healthy cells.

Pembrolizumab is an immunotherapy medication that helps your immune system fight cancer cells. It works by blocking a protein called PD-L1, which can help your immune system recognize and attack cancer cells more effectively.

Platinum-based Chemotherapy refers to traditional cancer treatment medications that contain platinum. These medications work by damaging the DNA of cancer cells, which prevents them from dividing and growing. This type of chemotherapy is commonly used to treat various types of cancer, including lung cancer.

Non-small Cell Lung Cancer – A type of lung cancer that begins in the large lung cells, including squamous cells, adenocarcinomas, and large-cell carcinomas. It typically grows and spreads more slowly than small cell lung cancer. The disease develops when lung cells begin to grow abnormally and form tumors. In non-squamous variants, the cancer originates specifically in glandular cells. When HER2-overexpressing, the cancer cells have too many HER2 proteins on their surface, which can make the cancer grow more aggressively. The disease can progress to become unresectable (unable to be removed by surgery) or metastatic (spread to other parts of the body).